期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 21, 期 5, 页码 677-690出版社
VSP BV
DOI: 10.1163/156856209X434683
关键词
Self-assembling peptides; hydrophobic compounds; pyrene; colloidal suspension; hydrophobic interaction
资金
- Chinese National '985 Project' of Education Ministry in Sichuan University, China
- Analytical and Testing Center of Sichuan University
The formation of colloidal suspension of a hydrophobic model compound, pyrene, with self-assembling peptide RAD16-I initially demonstrated the hydrophobic interaction between RAD16-I and hydrophobic compounds. The interaction between RAD16-I and pyrene in water was further investigated by using fluorescence spectroscopy and atomic force microscopy (AFM). It was observed that the fluorescence intensities of pyrene in aqueous RAD16-I solutions increased with the increase of RAD16-I at pyrene concentration of 0.1 mu M, and the I(1)/I(3) and I(1)/I(5) ratios of the emission spectra decreased as the RAD16-I concentration increased. Fluorescence results and differences in AFM images of RAD16-I aggregates with and without pyrene suggested that pyrene preferentially resided in non-polar microenvironments of RAD16-I due to the hydrophobic interaction between RAD16-I and pyrene. The potential of RAD16-I as a carrier for hydrophobic drugs was revealed with the property of pyrene transferring from the suspensions into egg phosphatidylcholine vesicles. This study gives an insight into exploitation of self-assembling peptides for encapsulation of hydrophobic compounds. (C) Koninklijke Brill NV, Leiden, 2010
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