Article
Polymer Science
Mark-Jefferson Buer Boyetey, Selorm Torgbo, Prakit Sukyai
Summary: Bio-based biomaterials, such as bacterial cellulose (BC) and hydroxyapatite (HA), show promise for bone tissue engineering due to their renewable nature and bioactivity. This review discusses the biosynthesis and modification of BC, as well as the use of bioceramics like HA to enhance its properties. The application of growth factors and immobilization strategies are also explored for their potential in improving bioactivity. Additionally, the development of modern additive manufacturing techniques like 3D bioprinting holds great potential for tailor-made materials in tissue engineering.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Yong Li, Xifeng Liu, Bipin Gaihre, Linli Li, Asghar Rezaei, A. Lee Miller Ii, Brian Waletzki, Sungjo Park, Andre Terzic, Lichun Lu
Summary: This study successfully synthesized zinc-doped hydroxyapatite powders with different ratios and used them to fabricate nanocomposite scaffolds. The scaffolds showed excellent biocompatibility and supported cell attachment, proliferation, osteogenic differentiation, and matrix mineralization.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Physiology
Xiaoyao Liu, Mingjing Yin, Ying Li, Jianqun Wang, Junlong Da, Zhongshuang Liu, Kai Zhang, Lixue Liu, Wenxuan Zhang, Peijun Wang, Han Jin, Bin Zhang
Summary: This study successfully improved the performance of L-PRF scaffold by using genipin as a crosslinker. The results showed that genipin-modified L-PRF had better biomechanical performance, slower biodegradation, good bioavailability, and sustained release of growth factors. In vitro and in vivo experiments demonstrated that 0.01% w/v and 0.1% w/v genipin-crosslinked L-PRF had good porous structure, significantly promoted cell proliferation, and enhanced bone regeneration.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
Article
Otorhinolaryngology
Xu Yao, Bing Mei Teh, Huan Li, Yi Hu, Juntao Huang, Cuiting Lv, Shizhong Bu, Minghao Zheng, Yi Shen
Summary: The study demonstrated that the combination of ACS and bFGF was effective in repairing traumatic tympanic membrane perforations, resulting in higher closure rates and improved hearing outcomes compared to other treatments.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Nanoscience & Nanotechnology
Jialong Chen, Guo Zhang, Yang Zhao, Muran Zhou, Aimei Zhong, Jiaming Sun
Summary: Cutaneous wound healing is a complex process that requires the coordination of various factors. Electrospun nanofibers have been found to provide a favorable microenvironment for skin tissue regeneration. Basic fibroblast growth factor (bFGF) is one of the most important growth factors in wound healing, promoting cell migration, proliferation, and differentiation. However, its application is limited by its short half-life and loss of bioactivity. This study aimed to develop a growth factor-releasing system that allows for controlled release to facilitate skin regeneration. The results showed that electrospun collagen-graphene oxide (Col-GO) scaffolds loaded with bFGF exhibited sustained release of the growth factor, leading to improved wound healing.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Polymer Science
Jue Wu, Qian Chen, Wenfei Wang, Yuhong Lin, Hong Kang, Zheng Jin, Kai Zhao
Summary: Type 2 diabetes (T2DM) is a disease characterized by high blood sugar levels caused by genetic and environmental factors. Insulin injections are currently the main treatment for diabetes, but they can lead to insulin resistance and other side effects. This study developed protein-based hypoglycemic drugs with both oral and injectable functions. The results showed that the prepared microspheres had good biocompatibility, stability, and long-lasting drug-release ability. They can be used as a promising nano-delivery system for hypoglycemic regulation through both oral and injectable administration.
Article
Materials Science, Multidisciplinary
Huajun Wu, Ya Gao, Lu Xiao, Qin Wei, Naiyin Zhang, Zhi Su, Chuang Ma, Tingjun Ye, Yingbo Wang
Summary: A bioactive PPy@HA/Dex nanocomposite coating with sustained osteoinductivity was successfully constructed on the titanium surface using pulse electrochemical method. The coating showed promising osteogenic ability and angiogenic property during osseointegration of implants.
MATERIALS & DESIGN
(2021)
Article
Cell Biology
Xin Shi, Liyuan Jiang, Xin Zhao, Bei Chen, Wei Shi, Yanpeng Cao, Yaowu Chen, Xiying Li, Yusheng He, Chengjie Li, Xiaoren Liu, Xing Li, Hongbin Lu, Can Chen, Jun Liu
Summary: A functional scaffold combining CBD-bFGF and BDDM was developed to enhance stem cell interaction, improve endothelial inducibility, increase stem cell quantity, promote granulation tissue formation and angiogenesis, showing potential application for diabetic wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Zhi-hu Zhao, Xin-long Ma, Jian-xiong Ma, Jia-yu Kang, Yang Zhang, Yue Guo
Summary: Bone defects are a common problem in the clinical setting, and bone tissue engineering offers an effective solution. In this study, SF/HAp scaffolds containing naringin-loaded PLGA microspheres were fabricated and investigated for their potential in bone tissue engineering. The results demonstrated that these scaffolds have promise as osteo-modulatory biomaterials for bone regeneration.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Nooshin Zandi, Banafsheh Dolatyar, Roya Lotfi, Yousef Shallageh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Nasim Annabi, Abdolreza Simchi
Summary: The engineered bilayer scaffolds, composed of gelatin nanofibers and composite hydrogels, show promising potential in accelerating wound healing process. The controlled delivery of growth factors on the bilayer scaffolds enhances wound closure and tissue regeneration. The unique structure of the scaffolds mimics the extracellular matrix, providing a platform for tailored growth factor release and improved adhesion to native tissue.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Dingkun Liu, Zhihui Liu, Jundong Zou, Lingfeng Li, Xin Sui, Bizhou Wang, Nan Yang, Bowei Wang
Summary: The development of a composite scaffold material containing sodium alginate, chitosan, and hydroxyapatite was studied for its ability to promote bone defect healing. Through various analyses, the composite scaffold showed good physical, chemical, antibacterial, and osteogenic properties, making it a promising new material for bone regeneration.
FRONTIERS IN MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Fangwei Qi, Zhihui Wang, Yang Shuai, Shuping Peng, Cijun Shuai
Summary: By constructing strontium substituted hydroxyapatite (SrHA), a sustained release system for polymer bone scaffolds was achieved. The released strontium ion (Sr2+) significantly promoted cell proliferation and differentiation. PLLA/SrHA scaffolds also exhibited improved mechanical properties, indicating their considerable potential for bone repair.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Applied
Yao Zhao, Xu Peng, Xiaoyang Xu, Mingzhen Wu, Fan Sun, Qiangwei Xin, Hongbo Zhang, Liangrui Zuo, Yilin Cao, Yuhang Xia, Jun Luo, Chunmei Ding, Jianshu Li
Summary: A chitosan/hydroxypropyltrimethyl ammonium chloride chitosan/hydroxyapatite/black phosphorus (CS/HC/HA/BP) hybrid photothermal scaffold with a multistage photothermal strategy was developed to address the complications after bone tumor resection. The scaffold demonstrated antitumor/antibacterial properties under photothermal stimulation and could eliminate osteosarcoma cells, E. coli, and S. aureus under NIR irradiation.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
R. Seda Tigli Aydin, Gokce Kaynak, Menemse Gumusderelioglu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Chemistry, Applied
Sema Alli, R. Seda Tigli Aydin, Abdulkadir Alli, Baki Hazer
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2015)
Article
Biochemistry & Molecular Biology
Menemse Gumusderelioglu, Ekin O. Tuncay, Gokce Kaynak, Tolga T. Demirtas, R. Seda Tigli Aydin, Sema S. Hakki
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2015)
Article
Materials Science, Textiles
R. Seda Tigli Aydin, Ayse Nur Eroglu, Ayse Karakecili, Ayla Calimli
FIBERS AND POLYMERS
(2016)
Article
Chemistry, Multidisciplinary
Ayse Nur Eroglu, R. Seda Tigli Aydin, Ayse Karakecili, Ayla Calimli
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2017)
Article
Engineering, Environmental
R. Seda Tigli Aydin, Elvan Akyol, Baki Hazer
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2018)
Article
Chemistry, Applied
R. Seda Tigli Aydin, Elvan Akyol, Baki Hazer
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2017)
Article
Engineering, Biomedical
R. Seda Tigli Aydin
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2013)
Article
Engineering, Biomedical
Gonca Karagoz Kayabasi, R. Seda Tigli Aydin, Menemse Gumusderelioglu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2013)
Article
Materials Science, Multidisciplinary
R. Seda Tigli Aydin, Seda Uyanik
JOURNAL OF MATERIALS RESEARCH
(2019)
Article
Chemistry, Applied
R. Seda Tigli Aydin, Fuesun Kazanci
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2018)
Article
Materials Science, Biomaterials
Kazim K. Moncal, R. Seda Tigli Aydin, Mohammad Abu-Laban, Dong N. Heo, Elias Rizk, Scott M. Tucker, Gregory S. Lewis, Daniel Hayes, Ibrahim T. Ozbolat
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Proceedings Paper
Engineering, Biomedical
R. Seda Tigli Aydin, Seda Uyanik
2016 20TH NATIONAL BIOMEDICAL ENGINEERING MEETING (BIYOMUT)
(2016)
Review
Chemistry, Medicinal
R. Seda Tigli Aydin
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2014)
Meeting Abstract
Cell & Tissue Engineering
M. Gumusderelioglu, E. O. Tuncay, G. Kaynak, T. T. Demirtas, R. S. T. Aydin, S. S. Hakki
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2014)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)