期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 20, 期 1, 页码 49-69出版社
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856208X393491
关键词
Poly(propylene fumarate); drug delivery; matrix modification; poly(ethylene glycol); poly(N-vinyl pyrrolidone); degradation; erosion
资金
- Bausch & Lomb (Rochester, NY, USA)
- German Research Foundation (DFG) [HA4444-1/1]
- Japanese Science Foundation Postdoctoral Fellowship
In this work, different modifications of photo-cross-linked poly(propylene fumarate)/poly(N-vinyl pyrrolidone) (PPF/PNVP) matrices were studied for their effect on the release kinetics of two ophthalmic drugs. The hydrophilicity of solid PPF/PNVP matrices loaded with acetazolamide (AZ) or timolol maleate (TM) was increased by adding various amounts of poly(ethylene glycol) (PEG) or by increasing the amount of N-vinyl pyrrolidone (NVP) in the polymer mixture prior to cross-linking. The in vitro release studies that utilized high-performance liquid chromatography for quantification revealed highly accelerated drug release from the matrices with increasing contents of the hydrophilic modifier. AZ was released from matrices containing 5% PEG in 56 days, which equals approximately 25% of the release period found for the unmodified matrices. A comparable acceleration in drug release was found for TM-loaded samples modified with 5% PEG. These studies further revealed that 1% PEG is sufficient to shorten the TM release duration by one-third. A significant acceleration in drug release was also found for the samples that were fabricated from a PPF-NVP mixture with increased NVP content. Matrix water content and erosion were assessed gravimetrically. Micro-computed tomography was used to image structural changes of the release systems and shed light on the drug-release mechanism. This study showed that hydrophilic matrix modifications of PPF/PNVP matrices accelerate the drug release of two ophthalmic drugs and represent a suitable tool to adjust drug-release rates from PPF-based matrices for different therapeutic needs. (C) Koninklijke Brill NV, Leiden, 2009
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