Article
Pharmacology & Pharmacy
Hinojal Zazo, Clara I. Colino, Carmen Gutierrez-Millan, Andres A. Cordero, Matthias Bartneck, Jose M. Lanao
Summary: This study developed a specific PBPK model to simulate the biodistribution of stavudine in rats after administration of a 40 nm gold nanoparticle-based drug delivery system. Higher biodistribution of stavudine into HIV reservoirs and modifications in pharmacokinetic parameters were observed compared to stavudine solution. This PBPK model approach may aid in pre-clinical extrapolation to other administration routes or species of stavudine gold nanoparticles.
Review
Chemistry, Multidisciplinary
Zichao Luo, Zhigao Yi, Xiaogang Liu
Summary: Surface-modified lanthanide nanoparticles have unique properties that make them widely used in cancer treatment. These nanoparticles have diagnostic capabilities suitable for image-guided therapies. They can accommodate therapeutic molecules on their surface, achieve combined cancer therapy, and easily modify targeting ligands for high affinity. They can also be engineered for precise and personalized tumor therapy.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Polymer Science
Samr Kassem, Stanislav S. Piletsky, Hasan Yesilkaya, Ozcan Gazioglu, Medhanie Habtom, Francesco Canfarotta, Elena Piletska, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky
Summary: This study demonstrated the biodistribution, clearance, and immunogenicity of solid-phase synthesized nanoMIPs in a rat model, showing their ability to cross the blood-brain barrier and be cleared from the body via feces and urine. With their low cytotoxicity and ability to access various tissue types, these results pave the way for in vivo applications of nanoMIPs.
Article
Medical Informatics
Chandrakanth Jayachandran Preetha, Hagen Meredig, Gianluca Brugnara, Mustafa A. Mahmutoglu, Martha Foltyn, Fabian Isensee, Tobias Kessler, Irada Pflueger, Marianne Schell, Ulf Neuberger, Jens Petersen, Antje Wick, Sabine Heiland, Juergen Debus, Michael Platten, Ahmed Idbaih, Alba A. Brandes, Frank Winkler, Martin J. van den Bent, Burt Nabors, Roger Stupp, Klaus H. Maier-Hein, Thierry Gorlia, Joerg-Christian Tonn, Michael Weller, Wolfgang Wick, Martin Bendszus, Philipp Vollmuth
Summary: This study utilized deep convolutional neural networks to synthesize post-contrast T1-weighted MRI sequences from pre-contrast MRI for tumor response assessment in neuro-oncology. The synthetic sequences showed a strong linear relationship in tumor volume assessment compared to true sequences, and similar performance in predicting overall survival in patients.
LANCET DIGITAL HEALTH
(2021)
Article
Chemistry, Medicinal
Hadel A. Abo El-Enin, Mohammed H. Elkomy, Ibrahim A. Naguib, Marwa F. Ahmed, Omar A. Alsaidan, Izzeddin Alsalahat, Mohammed M. Ghoneim, Hussein M. Eid
Summary: This research developed optimized berberine-laden nanostructured lipid carriers for efficient brain delivery via the intranasal route. Through in vivo experiments, it was demonstrated that the optimized formulation showed enhanced brain targeting.
Review
Chemistry, Multidisciplinary
Atiya Fatima, Md. Wasi Ahmad, Abdullah Khamis Ali Al Saidi, Arup Choudhury, Yongmin Chang, Gang Ho Lee
Summary: Gadolinium-based contrast agents represent a significant advancement in MRI technology, with potential for diverse applications and benefits in bioimaging. Future research should focus on establishing the safety, efficacy, and theragnostic capabilities of these agents.
Review
Instruments & Instrumentation
Bhavana Joshi, Abhijeet Joshi
Summary: The study highlights the potential of using magnetic nanoparticles for targeted brain therapy to overcome the limitations of the blood-brain barrier. Combining drug delivery with contrast imaging functionality can lead to more effective drug delivery and imaging.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Analytical
Ashutosh Kumar, Tamal Sarkar, Pratima R. Solanki
Summary: In this study, gadolinium oxide nanoparticles (Gd2O3 NPs) were synthesized and functionalized to create a highly efficient immunosensor for the detection of Vibrio cholera toxin (CT). The Gd2O3 NPs were produced using microwave irradiation and characterized using various techniques. The NPs were then functionalized with APTES and deposited onto an ITO-coated glass substrate. The immunosensor demonstrated excellent electrochemical reaction against CT, with a high sensitivity and low detection limit.
Review
Chemistry, Multidisciplinary
Jens B. Simonsen, Emil B. Kromann
Summary: Fluorescence-based techniques are widely used in nanomedicine research, but are rarely quantitative, making direct comparisons across studies difficult. This Commentary focuses on mechanisms of fluorescence-labeled nanoparticles and highlights pitfalls in quantitative fluorescence experiments that are often overlooked.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Pharmacology & Pharmacy
Myriam Lamrayah, Capucine Phelip, Celine Coiffier, Celine Lacroix, Thibaut Willemin, Thomas Trimaille, Bernard Verrier
Summary: This study investigates the potential of micelles composed of polylactide-block-poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone) as a delivery system for vaccines. The micelles were non-toxic and efficiently taken up by immune cells. Coupling of antigenic protein p24 on the micelles improved its antigenicity. In mouse immunization, the micelles showed comparable immune response intensity to gold standards and higher avidity index over time.
Article
Chemistry, Multidisciplinary
Fazel Abdolahpur Monikh, Sille Holm, Raine Kortet, Mandar Bandekar, Jukka Kekalainen, Arto Koistinen, Jari T. T. Leskinen, Jarkko Akkanen, Hannu Huuskonen, Anu Valtonen, Lan Dupuis, Willie Peijnenburg, Iseult Lynch, Eugenia Valsami-Jones, Jussi V. K. Kukkonen
Summary: Sub-micron plastics can be taken up by plants and transferred into food webs, with the chemical composition of plastics affecting their distribution and trophic transfer in organisms. However, no biomagnification of plastic particles was observed in organisms.
Article
Chemistry, Multidisciplinary
Ramesh Marasini, Sagar Rayamajhi, Anthony Moreno-Sanchez, Santosh Aryal
Summary: Magnetic Resonance Imaging (MRI) is a widely used imaging technique in medical diagnostics, but the use of contrast agents has been associated with deposition of metals in vital organs. A new contrast agent has been designed and tested for potential applicability in clinical settings.
Article
Nanoscience & Nanotechnology
Julia Nowak-Jary, Beata Machnicka
Summary: Magnetic iron oxide nanoparticles have broad potential applications in medical and biological sciences. They can be used in targeted drug delivery, internal radiotherapy, magnetic resonance imaging, hyperthermia, and radiolabelling. The appropriate design of nanoparticles allows them to be delivered to desired tissues and organs, with an external magnetic field increasing their biodistribution. Factors such as size, shape, surface charge, coating molecules, and route of administration affect their biodistribution. Modern techniques can determine nanoparticle accumulation sites and concentration in isolated tissues or the body in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Joanna Sobska, Magdalena Waszkielewicz, Anna Podlesny-Drabiniok, Joanna Olesiak-Banska, Wojciech Krezel, Katarzyna Matczyszyn
Summary: Gold nanoparticles hold great promise for clinical and preclinical applications, but toxicity and accumulation issues are major barriers. Research on Au18 gold nanoclusters with low toxicity and good biodistribution profile may contribute to future biomedical studies.
Article
Mechanics
Stephane Roux, Francois Hild
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2020)
Article
Nanoscience & Nanotechnology
Vladimir Ivosev, Gloria Jimenez Sanchez, Lenka Stefancikova, Darine Abi Haidar, Cesar R. Gonzalez Vargas, Xiaomin Yang, Rana Bazzi, Erika Porcel, Stephane Roux, Sandrine Lacombe
Article
Engineering, Mechanical
Francois Hild, Stephane Roux
JOURNAL OF STRAIN ANALYSIS FOR ENGINEERING DESIGN
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanna-Marina Chevalme, Lotfi Boudali, Mathieu Gauthe, Caroline Rousseau, Andrea Skanjeti, Charles Merlin, Philippe Robin, Anne-Laure Giraudet, Marc Janier, Jean-Noel Talbot
Summary: The study compared the performance of PSMA-11 PET/CT in patients with BCR who previously had negative or equivocal FCH PET/CT. The study found that the PR of PSMA-11 was influenced by various factors including sPSA levels, patients' age, initial therapy, and the results of FCH PET/CT. Different imaging protocols for PSMA-11 PET/CT did not significantly affect the PR, and no adverse events were reported after PSMA-11 injection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Engineering, Multidisciplinary
Leonard Turpin, Stephane Roux, Olivier Caty, Sebastien Denneulin
Summary: This paper presents an experimental method and full-field measurement procedure for determining the thermo-mechanical properties of complex 3D woven ceramic composite materials, capturing 3D tomographic images of the sample at different loading stages and mapping the thermal field onto a 3D mesh using a pin-hole projective model. An integrated digital image correlation algorithm is proposed to calibrate the projection model, with a focus on the silhouette of the sample shape. The procedure is illustrated with an experimental case study.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2021)
Article
Microscopy
Jan Neggers, Eva Heripre, Marc Bonnet, Denis Boivin, Alexandre Tanguy, Simon Hallais, Fabrice Gaslain, Elodie Rouesne, Stephane Roux
Summary: This article discusses a novel approach to reconstruct topography using BSE images from multiple detectors, which is efficient and independent of detector number or orientation. The method is based on a modal decomposition of the principal image components and requires minimal calibration.
Article
Mechanics
K. Cosseron, D. Melle, J-F Diebold, F. Hild, S. Roux
Summary: This study focuses on determining tire-rim interface loadings for aircraft wheel design and proposes an optimal sensor placement method to identify loading parameters. By optimizing wheel instrumentation, uncertainties in parameters can be significantly reduced, ensuring reliable inverse identifications.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2021)
Article
Engineering, Multidisciplinary
Edward Ando, Benjy Marks, Stephane Roux
Summary: This study introduces a novel method for measuring the position of single-sized spheres in 3D from a single, divergent, radiographic projection. By utilizing Fourier transform and minimizing projection residual, the method can determine the particle centers of equal-sized particles. The technique is validated on synthetic data and real radiographs, with the measurement uncertainty evaluated.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Multidisciplinary
X. Chang, S. Hallais, S. Roux, K. Danas
Summary: The study introduces a new atomic force microscope technique, PeakForce quantitative nanomechanical mapping, which allows the detection of surface topography and various mechanical properties. The use of proper orthogonal decomposition technique is proposed to analyze and segment experimental data efficiently and robustly. This method can effectively identify the underlying phase constituents in materials and decouple them from surface topography.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Gautier Laurent, Chahrazad Benbalit, Claire Chretien, Constantin Dupuis, Yann Pellequer, Rana Bazzi, Vivek Sudam Thakare, Franck Denat, Stephane Roux, Arnaud Beduneau
Summary: Encapsulation of gold nanoparticles in polymeric nanoparticles can avoid rapid renal clearance, prolong vascular residence time, and promote passive uptake in cancer cells. This encapsulation method does not alter the contrast agent properties of the gold nanoparticles, paving the way for innovative imaging-guided anticancer therapies in personalized medicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Correction
Nanoscience & Nanotechnology
Agnieszka Pasciak, Riccardo Marin, Lise Abiven, Aleksandra Pilch-Wrobel, Malgorzata Misiak, Wujun Xu, Katarzyna Prorok, Oleksii Bezkrovnyi, Lukasz Marciniak, Corinne Chaneac, Florence Gazeau, Rana Bazzi, Stephane Roux, Bruno Viana, Vesa-Pekka Lehto, Daniel Jaque, Artur Bednarkiewicz
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Riccardo Marin, Lise Abiven, Aleksandra Pilch-Wrobel, Malgorzata Misiak, Wujun Xu, Katarzyna Prorok, Oleksii Bezkrovnyi, Lukasz Marciniak, Corinne Chaneac, Florence Gazeau, Rana Bazzi, Stephane Roux, Bruno Viana, Vesa-Pekka Lehto, Daniel Jaque, Artur Bednarkiewicz
Summary: Functional colloidal nanoparticles capable of converting between various energy types are widely used in applications such as cancer therapy. This study evaluated the light-to-heat conversion properties of 17 different nanoheaters and ranked them qualitatively. The results showed that considering only the light-to-heat conversion efficiency is not enough, and the absorption coefficient should also be taken into account.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Theotim Lucas, Clement Linger, Thomas Naillon, Mahshid Hashemkhani, Lise Abiven, Bruno Viana, Corinne Chaneac, Gautier Laurent, Rana Bazzi, Stephane Roux, Sonia Becharef, Giulio Avveduto, Florence Gazeau, Jerome Gateau
Summary: Photoacoustic spectroscopy provides a precise and robust method of analyzing the photothermal capabilities of nanoagents in aqueous solutions, without the need for models.
Article
Chemistry, Multidisciplinary
Alba Nicolas-Boluda, Gautier Laurent, Rana Bazzi, Stephane Roux, Emmanuel Donnadieu, Florence Gazeau
Summary: This study reveals that gold decorated iron oxide nanoflowers (GIONF) can significantly impact the tumor immune environment, promoting recruitment of monocytes and creating a pro-inflammatory anti-tumor microenvironment. Furthermore, mild hyperthermia treatment also leads to an increase in CD8+ T lymphocytes and pro-inflammatory cytokines in addition to GIONF effects.
Article
Chemistry, Multidisciplinary
Maxime Durand, Elodie Lelievre, Alicia Chateau, Alexandre Berquand, Gautier Laurent, Philippe Carl, Stephane Roux, Lise Chazee, Rana Bazzi, Frederic Eghiaian, Justine Jubreaux, Philippe Ronde, Muriel Barberi-Heyob, Pascal Chastagner, Jerome Devy, Sophie Pinel
Summary: The study demonstrated that Au@DTDTPA(Gd) nanoparticles can effectively inhibit the invasive potential of U251 glioma cells by affecting their biomechanical properties, reducing protrusions formation, and stabilizing focal adhesion plaques. These results highlight the potential of Au@DTDTPA(Gd) nanoparticles for therapeutic management of astrocytic tumors.
