期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 25, 期 2, 页码 161-177出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328209344003
关键词
pyridoxine hydrochloride; thiamine hydrochloride; alginate; montmorillonite; nanocomposites
资金
- Council of Scientific and Industrial Research (CSIR) [NWP 0010]
Sustained intestinal delivery of thiamine hydrochloride (Vitamin B-1; VB1) and pyridoxine hydrochloride (Vitamin B-6; VB6) seems to be a feasible alternative to existing therapy. The vitamins (VB1/VB6) intercalated in montmorillonite (MMT) and intercalated VB1/VB6-MMT hybrid is further used for synthesis of VB1/VB6-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB1/VB6-MMT hybrid, VB1/VB6-alginate and VB1/VB6-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB1/VB6 releases suddenly from VB1/VB6-MMT hybrid and is pH dependent. The controlled release of VB1/VB6 from VB1/VB6-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB1/VB6-MMT hybrid and VB1/VB6-alginate beads.
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