Article
Materials Science, Biomaterials
Siriporn Tanodekaew, Somruethai Channasanon, Pakkanun Kaewkong
Summary: Polylactide (PLA) and hydroxyapatite (HA) composite is a promising material for biomedical applications. In this study, a novel combination of star-shaped and linear PLA powder with various amounts of nano HA was developed as an in situ forming cement for bone substitute. The effects of different amounts of initiator and nano HA powder on various properties of the composite cement were studied. The results demonstrated that the optimal cement formulation was found to be at 15 wt% HA, which allowed for in situ hardening with satisfactory biocompatibility and mechanical support for bone regeneration during deterioration.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Review
Engineering, Biomedical
A. Kavitha Sri, C. Arthi, N. R. Neya, G. S. Hikku
Summary: Regenerative medicine offers hope for reforming defective organs, particularly bones, through the use of tissue engineering technology. Scaffold materials, such as nano-HA/collagen complex that support cell attachment and growth, have shown promise in bone regeneration. Recent studies have found that nano-HA exhibits higher cell adherence and subsequent growth, making it an ideal scaffold material for minimizing the limitations of conventional bone regeneration methods. This review focuses on the use and fabrication of nano-HA/collagen complex as a scaffold material for bone regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Ting-Ting Ma, Ze-Yu Niu, Jian-Guo Liao, Yan-Qun Li, Yi-Jia Guan, Jing-Xian Liu, Yu-Fen Xie
Summary: A novel nano-hydroxyapatite/poly(desaminotyrosyl-tyrosin-hexyl ester) carbonate composite bone cement with high compressive strength and good biocompatibility was developed. It can effectively meet the repair demands of cancellous bone parts and has potential applications in the field of bone repair.
SCIENCE OF ADVANCED MATERIALS
(2022)
Article
Materials Science, Ceramics
Melike Nur Ozder, Fatih Ciftci, Ozge Rencuzogullari, Elif Damla Arisan, Cem Bulent Ustundag
Summary: This study investigates the properties of in situ synthesis of graphene oxide-hydroxyapatite (GO/HA) nanocomposite materials with different doping ratios for bone tissue support applications. The results show that scaffolds containing 0.5% and 1% GO (w/w) exhibit excellent cell proliferation and adhesion, making them promising materials for bone support applications.
CERAMICS INTERNATIONAL
(2023)
Review
Polymer Science
Laura Ricciotti, Antonio Apicella, Valeria Perrotta, Raffaella Aversa
Summary: With advancements in bone tissue engineering, the development of innovative biomaterials is crucial for improving bone healing. This review thoroughly examines the current applications and future potential of geopolymers in bone tissue engineering. Traditional bioscaffold materials are also compared, analyzing their strengths and weaknesses. The concerns regarding the widespread use of alkali-activated materials as biomaterials and the potential of geopolymers as ceramic biomaterials are discussed.
Article
Biochemistry & Molecular Biology
Eda Ciftci Dede, Petek Korkusuz, Elif Bilgic, Mehmet Alper Cetinkaya, Feza Korkusuz
Summary: Boron combined with nano-hydroxyapatite can stimulate new bone formation. Injecting boron-containing nano-hydroxyapatite composites with hyaluronan into rabbit femurs can increase bone mineral density and new bone formation. This treatment shows promise in preventing femoral fractures in osteoporosis patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xiao-Liang Liu, Chuan-Jian Zhang, Jing-Jing Shi, Qin-Fei Ke, Yu-Wei Ge, Zhen-An Zhu, Ya-Ping Guo
Summary: Autogenous bone grafting is limited in treating critical bone defects due to its drawbacks, thus effective bone substitutes are needed. Inspired by the nacre architecture, a layered nano-hydroxyapatite/chitosan composite scaffold was designed and fabricated. The scaffold promoted osteogenesis and inhibited osteoclast activation, offering a promising platform for bone regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaojing Mo, Dianjian Zhang, Keda Liu, Xiaoxi Zhao, Xiaoming Li, Wei Wang
Summary: This review summarizes the classification of n-HAp composites, the application of n-HAp composite scaffolds loaded with bioactive factors and drugs in bone tissue engineering, the drug loading methods of n-HAp composite scaffolds, and prospects the research direction of n-HAp composite scaffolds in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Clinical Neurology
Zeynep Bal, Feza Korkusuz, Hiroyuki Ishiguro, Rintaro Okada, Junichi Kushioka, Ryota Chijimatsu, Joe Kodama, Daisuke Tateiwa, Yuichiro Ukon, Shinichi Nakagawa, Eda Ciftci Dede, Merve Gizer, Petek Korkusuz, Hideki Yoshikawa, Takashi Kaito
Summary: The novel composite material of nHAp/PLA-PEG demonstrated efficient bone regeneration with low-dose BMP-2. ELISA results showed sustained release of BMP-2 up to day 21, with 91.6% of specimens in both the low- and high-dose groups achieving solid fusion according to μCT and manual palpation test, while none in the control group achieved bony fusion.
Article
Materials Science, Composites
Selvam Sivasankari, Rajappan Kalaivizhi, Natesan Gowriboy, Munuswamy Ramanujam Ganesh, Musthafa Shazia Anjum
Summary: This study describes the preparation and characterization of HA nanomaterial incorporated cellulose acetate/polyetherimide membrane using a simple and cost-efficient method. Structural and morphological analysis was conducted using various techniques, revealing significant changes in the membrane's surface and cross section with the addition of HA nanoparticles. Moreover, the presence of inorganic nanoparticles impacted the thermal and hydrophilic properties of the membrane.
POLYMER COMPOSITES
(2021)
Article
Materials Science, Multidisciplinary
Maryam Mehdizade, Ali Reza Eivani, Hamed Asgari, Yashar Naghshin, Hamid Reza Jafarian
Summary: In this study, a Mg-based biomedical composite was successfully fabricated by adding Hydroxyapatite bioactive nanoparticles into a substrate of bioabsorbable WE43 Mg alloy using multi pass friction stir processing (FSP). The study showed that increasing the number of FSP passes led to a decrease in grain size, improved homogeneity of Hydroxyapatite bioactive particles, and reduced agglomeration. In vitro Biodegradation tests demonstrated a decrease in weight loss and biodegradation rate as the number of FSP passes increased. Additionally, immersion in simulated body fluid showed that the fabricated Mg-Hydroxyapatite bio-composites exhibited bone-like apatite forming ability. The biocompatibility of the bio-composites was also evaluated and the results showed that the viability of L-929 fibroblast cells improved with an increase in the number of FSP passes. The addition of Hydroxyapatite particles and an increase in the number of FSP passes also increased the yield strength values of the samples.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Biochemistry & Molecular Biology
Zong-Ju Chen, Hui-Hong Shi, Liang Zheng, Hua Zhang, Yu-Ying Cha, Hui-Xian Ruan, Yi Zhang, Xiu-Cheng Zhang
Summary: The composite aerogel with a dual network structure composed of sheet-like silk fibroin and reticular cellulose wrapping nano-hydroxyapatite on the surface showed high mechanical strength and toughness. In vitro cell culture demonstrated that HEK-293T cells had a high ability of adhesion, proliferation and differentiation on the composite aerogels, indicating potential application in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Mahdieh Alipour, Javad Ashrafihelan, Roya Salehi, Zahra Aghazadeh, Aysa Rezabakhsh, Armin Hassanzadeh, Masomeh Firouzamandi, Morteza Heidarzadeh, Reza Rahbarghazi, Marziyeh Aghazadeh, Sepideh Saghati
Summary: Injectable hydrogels based on PCL-PEG-PCL, PCL-PEG-PCL-Gel, and PCL-PEG-PCL-Gel/nHA were synthesized and evaluated in a mouse model, showing promising results for bone regeneration with minimal toxic and inflammatory effects.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Polymer Science
Mozan Hassan, Abbas Khaleel, Sherif Mohamed Karam, Ali Hassan Al-Marzouqi, Ihtesham Ur Rehman, Sahar Mohsin
Summary: Bacterial infection associated with bone grafts is a major challenge that can cause implant failure. A recent study found that a composite scaffold made of strontium/zinc co-doped nanohydroxyapatite and Poly (lactic-co-glycolic acid) showed enhanced antibacterial activity against Staphylococcus aureus, while promoting the growth of osteoblast cells. The 4% Sr/Zn-nHAp-PLGA scaffold was identified as a suitable candidate for bone regeneration.
Article
Chemistry, Multidisciplinary
Peng Zhang, Yuhui Ma, Zhiyong Zhang, Xiao He, Jing Zhang, Zhi Guo, Renzhong Tai, Yuliang Zhao, Zhifang Chai
Article
Engineering, Biomedical
Gaurav Lalwani, Allan M. Henslee, Behzad Farshid, Priyanka Parmar, Liangjun Lin, Yi-Xian Qin, F. Kurtis Kasper, Antonios G. Mikos, Balaji Sitharaman
ACTA BIOMATERIALIA
(2013)
Article
Biochemistry & Molecular Biology
T. Corrales, I. Larraza, F. Catalina, T. Portoles, C. Ramirez-Santillan, M. Matesanz, C. Abrusci
Review
Chemistry, Applied
Nasrullah Shah, Mazhar Ul-Islam, Waleed Ahmad Khattak, Joong Kon Park
CARBOHYDRATE POLYMERS
(2013)
Article
Chemistry, Applied
Chunyu Chang, Na Peng, Meng He, Yoshikuni Teramoto, Yoshiyuki Nishio, Lina Zhang
CARBOHYDRATE POLYMERS
(2013)
Article
Engineering, Environmental
Hem Raj Pant, Prabodh Risal, Chan Hee Park, Leonard D. Tijing, Yeon Jun Jeong, Cheol Sang Kim
CHEMICAL ENGINEERING JOURNAL
(2013)
Article
Biophysics
Hem Raj Pant, Prabodh Risal, Chan Hee Park, Leonard D. Tijing, Yeon Jun Jeong, Cheol Sang Kim
COLLOIDS AND SURFACES B-BIOINTERFACES
(2013)
Article
Polymer Science
Abdalla Abdal-hay, Hem Raj Pant, Jae Kyoo Lim
EUROPEAN POLYMER JOURNAL
(2013)
Article
Nanoscience & Nanotechnology
Masoud Mozafari, Erfan Salahinejad, Vahid Shabafrooz, Mostafa Yazdimamaghani, Daryoosh Vashaee, Lobat Tayebi
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2013)
Article
Nanoscience & Nanotechnology
Xuyuan Ji, Wenjing Yang, Ting Wang, Chun Mao, Lingling Guo, Jiangqiang Xiao, Nongyue He
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2013)
Article
Multidisciplinary Sciences
Anders Palmquist, Kathryn Grandfield, Birgitta Norlindh, Torsten Mattsson, Rickard Branemark, Peter Thomsen
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2012)
Article
Biochemistry & Molecular Biology
Hossein K. Heris, Meysam Rahmat, Luc Mongeau
MACROMOLECULAR BIOSCIENCE
(2012)
Article
Materials Science, Multidisciplinary
Chao Guo, Xi Guo, Ning Cai, Yinsheng Dong
Article
Chemistry, Physical
Jun Yang, Li-Hong Deng, Chun-Rui Han, Jiu-Fang Duan, Ming-Guo Ma, Xue-Ming Zhang, Feng Xu, Run-Cang Sun
Article
Chemistry, Multidisciplinary
Kuilin Lai, Wen Jiang, James Z. Tang, Yao Wu, Bin He, Gang Wang, Zhongwei Gu
