期刊
JOURNAL OF BIOLOGICAL PHYSICS
卷 35, 期 4, 页码 337-346出版社
SPRINGER
DOI: 10.1007/s10867-009-9141-4
关键词
Amyotrophic lateral sclerosis; Glutamate uptake; Neurotrophic factors; Excitotoxicity; AMPA receptor
类别
资金
- Fund for Scientific Research Flanders (F.W.O. Vlaanderen)
- Association Belge contre les Maladies neuro-Musculaires (ABMM)
- Association contre les Myopathies (AFM)
- University of Leuven
- Belgian Federal Science Policy Office (Molecular Genetics and Cell Biology) [P6/43]
Selective motor neuron death during amyotrophic lateral sclerosis (ALS) is a non-cell autonomous process in which non-neuronal cells induce and/or contribute to the disease process. The non-neuronal cells that are clearly involved in the pathogenesis of the disease are the surrounding astrocytes. Under normal conditions, astrocytes remove glutamate from the synaptic cleft and release trophic factors. In addition, these cells determine the functional characteristics of motor neurons. Recent evidence suggests that activation of astrocytes in a degenerative disease like ALS disturbs the crosstalk between astrocytes and motor neurons, which could contribute to and/or accelerate selective motor neuron death. These new insights may contribute to the development of therapeutic approaches to slow this fatal neurodegenerative disease.
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