Article
Biotechnology & Applied Microbiology
Yan Wang, Hai-Nan Su, Hai-Yan Cao, Si-Min Liu, Shi-Cheng Liu, Xia Zhang, Peng Wang, Chun-Yang Li, Yu-Zhong Zhang, Xi-Ying Zhang, Xiu-Lan Chen
Summary: Collagenases produced by pathogenic Vibrio species are important virulence factors. This study characterizes the M9A collagenase VP397 from Marine Vibrio pomeroyi strain 12613 and reveals its degradation mechanism on type I collagen. VP397 first attacks the C-telopeptide region and then digests tropocollagen fragments at the Y-Gly bonds. This study provides new knowledge about the collagenolytic mechanism of Vibrio collagenase, which has implications for understanding Vibrio pathogenesis and developing industrial and medical applications of collagenase.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wen Li, Naiwei Chi, Rathnayake A. C. Rathnayake, Rong Wang
Summary: The study found that a hybrid matrix of collagen I and collagen III can most effectively activate fibroblasts, promoting cell polarization and collagen synthesis. This is achieved through a fine balance between biochemical and biophysical cues on the hybrid matrix.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Soichiro Sawamura, Katsunari Makino, Maho Ide, Shuichi Shimada, Ikko Kajihara, Takamitsu Makino, Masatoshi Jinnin, Satoshi Fukushima
Summary: In patients with systemic sclerosis (SSc), the levels of alpha 2(I) collagen are higher than alpha 1(I) collagen in fibroblasts. Further investigation of the overall regulatory mechanisms of type I collagen may help to understand the aberrant collagen metabolism in SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Marta Vallecillo-Rivas, Manuel Toledano-Osorio, Cristina Vallecillo, Manuel Toledano, Raquel Osorio
Summary: This study investigated the biodegradation pattern of five collagen membranes from different origins, with Evolution X-fine collagen membrane from porcine pericardium showing the highest resistance. On the other hand, Biocollagen and Parasorb Resodont from equine origin experienced the greatest degradation in certain challenge tests. Bacterial collagenase solution was found to be the most aggressive testing method.
Article
Biochemistry & Molecular Biology
Qin Zou, Xue Wang, Rong Yuan, Zhengyin Gong, Chenggang Luo, Ying Xiong, Yanzhi Jiang
Summary: Skin thickness is influenced by the expression of collagen I in fibroblasts. Using Chenghua pigs as model animals, this study identified significant morphological differences between Chenghua pigs and Large White pigs at the transcript level. Additionally, a circRNA called circ0044633 was found to promote fibroblast proliferation and collagen I synthesis by sponging miR-23b and regulating CADM3 and MAP4K4 expression. Over-expression of circ0044633 increased skin thickness and collagen I content in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Parkyong Song, Han-Seul Jo, Wan-Seog Shim, Yang Woo Kwon, Sungwon Bae, Yonghoon Kwon, Bakhovuddin Azamov, Jin Hur, Dongjun Lee, Sung Ho Ryu, Jong Hyuk Yoon
Summary: Emodin promotes type I collagen synthesis in dermal fibroblasts, potentially serving as a candidate for treating skin aging and wrinkles.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Stephanie L. K. Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
Summary: Defective type I collagen in the heart leads to cardiomyopathy with fibroblast expansion, activation, and fibrotic ECM deposition. However, acute inhibition of type I collagen production can have an anti-fibrotic and anti-hypertrophic effect.
Article
Biochemistry & Molecular Biology
Maria Blanco, Noelia Sanz, Ana C. Sanzhez, Begona Correa, Ricardo I. Perez-Martin, Carmen G. Sotelo
Summary: This study aimed to achieve a high molecular weight (Mw) in Blue Shark Collagen Hydrolysate by studying different hydrolysis parameters and testing its effect on mRNA Type I collagen expression. Analysis revealed differences in Mw of blue shark collagen hydrolysates depending on hydrolysis conditions, with papain leading to higher Mw hydrolysate than Alcalase. The highest Mw hydrolysate showed no cytotoxicity or proliferation effect on fibroblast cell culture, but exhibited an increasing effect on mRNA expression and pro-collagen I production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cedric Zeltz, Maryam Khalil, Roya Navab, Ming-Sound Tsao
Summary: Collagen type XI restrains collagen remodeling and cell migration mediated by cancer-associated fibroblasts (CAF), thereby limiting the invasion of lung cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yongli Cai, Wei Liu, Yang Yu, Ligao Liu, Qijun Pei, Han Wu, Teng He, Jianping Guo, Anan Wu, Ping Chen
Summary: This study presents a new approach for the hydrogenolysis of aniline using lithium hydride (LiH) via a chemical looping process, resulting in the formation of benzene and ammonia. In contrast to transition metal catalysts, this LiH-mediated chemical looping HDN process exhibits a high denitrogenated product formation rate.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Chemical
Thidarat Wongsawa, Watcharapong Ampronpong, Natthapol Traiwongsa, Ura Pancharoen, Wikorn Punyain, Suphot Phatanasri
Summary: Pure sunflower oil is newly used to extract mercury (Hg(I)) from synthetic water to protect the environment from hazardous metals and promote a benign extraction method. Optimal conditions of influencing parameters have been determined, and the extraction mechanism, reaction order, rate constant, and thermodynamic parameters of Hg(I) extraction have been investigated. Extraction of Hg(I) from other metals in industrial wastewater has also been carried out.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Multidisciplinary
Luca Bosetti, Byeongho Ahn, Marco Mazzotti
Summary: In this paper, the thermodynamic effect of the presence of the seed crystal surface on secondary nucleation is derived. The calculation shows that subcritical clusters close to the seed surface are more likely to become secondary nuclei, leading to a stabilization effect that can be observed in the study.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Cell Biology
Nicola L. Stevenson, Dylan J. M. Bergen, Yinhui Lu, M. Esther Prada-Sanchez, Karl E. Kadler, Chrissy L. Hammond, David J. Stephens
Summary: Knockout of the golgin giantin leads to skeletal and craniofacial defects due to changes in glycosylation and extracellular matrix deposition. Our study reveals a conserved role for giantin in collagen biosynthesis and extracellular matrix assembly, as well as a giantin-dependent pathway for intracellular procollagen processing.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Maxime Michelas, Jean-Claude Daran, Alix Sournia-Saquet, Christophe Fliedel, Rinaldo Poli
Summary: The addition of benzoyl peroxide to [Co-II(acac)(2)] selectively produces [Co-III(acac)(2)(O2CPh)], a mononuclear Co-III complex with an octahedral coordination geometry. This compound can serve as a thermal initiator for radical polymerisation. Addition of ligands (L = py, NEt3) induces chelate ring opening and formation of different isomers. The addition of py strengthens the Co-III-O2CPh bond and lowers the initiator efficiency, while the addition of NEt3 quenches the benzoate radical.
DALTON TRANSACTIONS
(2023)
Article
Biophysics
Ningfei Shen, Xiaoli Qi, Dmitry V. Bagrov, Sergey P. Krechetov, Mars G. Sharapov, Mikhail O. Durymanov
Summary: Conjugating PLGA microparticles loaded with antioxidant enzymes to fibroblasts enhanced cell migration, collagen production, and resistance to oxidative stress. This novel modification approach could be beneficial for wound repair, cosmetic dermatology, and tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi, U. Tarantino
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Cell Biology
Donato Di Pierro, Chiara Ciaccio, Diego Sbardella, Grazia Raffaella Tundo, Roberta Bernardini, Paolo Curatolo, Cinzia Galasso, Virginia Pironi, Massimiliano Coletta, Stefano Marini
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Virginia Veronica Visconti, Ida Cariati, Simona Fittipaldi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino, Annalisa Botta
Summary: DNA methylation is a crucial epigenetic mechanism in regulating gene expression, and plays an important role in aging-bone diseases such as osteoporosis and osteoarthritis. Recent studies have shown new discoveries on the involvement of DNA methylation in the pathogenesis of these diseases, highlighting the significance of investigating the specific tissues associated with them.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chiara Greggi, Ida Cariati, Federica Onorato, Riccardo Iundusi, Manuel Scimeca, Umberto Tarantino
Summary: The study revealed that PTX3 plays a role in osteogenic differentiation and possesses osteoinductive capacity, making it a potential biomarker and therapeutic agent for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Umberto Tarantino, Chiara Greggi, Virginia Veronica Visconti, Ida Cariati, Mariagrazia Tallarico, Matteo Fauceglia, Riccardo Iundusi, Marco Albanese, Carlo Chiaramonte, Elena Gasbarra
Summary: Osteosarcopenia, a condition affecting frail elderly individuals, shows a significant correlation between handgrip strength and bone density, suggesting a potential new parameter for its diagnosis in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Ida Cariati, Manuel Scimeca, Roberto Bonanni, Rebecca Triolo, Valerio Naldi, Giuseppe Toro, Mario Marini, Virginia Tancredi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino
Summary: Exposure to microgravity can affect musculoskeletal health and the use of anti-myostatin antibodies shows promising results in promoting cell survival in primary human satellite cell cultures exposed to simulated microgravity.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Roberto Bonanni, Ida Cariati, Virginia Tancredi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino
Summary: Musculoskeletal pain is a growing problem that causes significant socio-economic burden. Understanding the underlying pathological mechanisms and the relationship between immune cells and neurons is crucial for effective evaluation and treatment of this pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Umberto Tarantino, Ida Cariati, Chiara Greggi, Riccardo Iundusi, Elena Gasbarra, Giovanni Iolascon, Andreas Kurth, Kristina E. Akesson, Mary Bouxsein, Paolo Tranquilli Leali, Roberto Civinini, Francesco Falez, Maria Luisa Brandi
Summary: Osteoporotic fractures are a major problem in healthcare systems worldwide. Fragility fractures of the hip have a greater impact on morbidity, mortality, and healthcare costs than other fracture sites. There is a lack of awareness of osteoporosis and most high-risk individuals do not receive adequate treatment.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
U. Tarantino, C. Greggi, V. V. Visconti, I Cariati, R. Bonanni, B. Gasperini, R. Iundusi, E. Gasbarra, P. Tranquilli Leali, M. L. Brandi
Summary: Frailty fractures, especially femoral fractures, place a significant socioeconomic burden on the healthcare system globally. The fracture liaison service (FLS) represents a multidisciplinary approach to post-fracture care for frail patients. The Italian Society of Orthopaedics and Traumatology (SIOT) is working towards accrediting multiple FLS centers throughout Italy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Rheumatology
Umberto Tarantino, Chiara Greggi, Virginia Veronica Visconti, Ida Cariati, Roberto Bonanni, Beatrice Gasperini, Italo Nardone, Elena Gasbarra, Riccardo Iundusi
Summary: Osteosarcopenia is a condition characterized by the simultaneous presence of osteopenia/osteoporosis and sarcopenia, and it is caused by dysfunctions in the bone-muscle unit. While there are still gaps in our understanding of the underlying mechanisms, exercise and nutrition interventions have been found to be essential in combating osteosarcopenia.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Review
Rheumatology
Elena Gasbarra, Eleonora Piccirilli, Chiara Greggi, Flavio Trapani, Riccardo Iundusi, Umberto Tarantino
Summary: This article provides an overview of the advantages and disadvantages of cemented and non-cemented implants from a biological and biomechanical perspective.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Review
Medicine, General & Internal
Umberto Tarantino, Chiara Greggi, Ida Cariati, Guglielmo Manenti, Matteo Primavera, Paolo Ferrante, Riccardo Iundusi, Elena Gasbarra, Andrea Gatti
Summary: Bone marrow edema is a typical imaging finding in stress-related bone injuries of professional and amateur athletes, with unclear clinical significance. The correlation between imaging pattern of BME, clinical history, and sports activity type is essential for correct diagnosis and treatment.
MEDICINA-LITHUANIA
(2021)
Review
Infectious Diseases
Alessandro Russo, Umberto Tarantino, Gabriella D'Ettorre, Carlo Della Rocca, Giancarlo Ceccarelli, Elena Gasbarra, Mario Venditti, Riccardo Iundusi
Summary: A case of vertebral osteomyelitis caused by Bacillus circulans was observed in an immunocompetent patient, which is the first reported case in the literature. Vertebral osteomyelitis presents a challenge for clinicians due to its insidious and indolent course, making diagnosis difficult and often delayed.
Article
Geriatrics & Gerontology
Giulia Di Pietro, Manuel Scimeca, Riccardo Iundusi, Monica Celi, Elena Gasbarra, Umberto Tarantino, Silvia Capuani
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Orthopedics
F. F. Sesti, F. Oliva, R. Iundusi
MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL
(2019)