期刊
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷 16, 期 5, 页码 789-798出版社
SPRINGER
DOI: 10.1007/s00775-011-0780-0
关键词
Vanadium; Unfolded protein responses; beta cell; Free fatty acid; Palmitate
资金
- NSFC [20971008]
- Research Fund for the Doctoral Program of Higher Education of China
Endoplasmic reticulum (ER) stress induced by free fatty acids (FFA) is important to beta-cell loss during the development of type 2 diabetes. To test whether vanadium compounds could influence ER stress and the responses in their mechanism of antidiabetic effects, we investigated the effects and the mechanism of vanadyl bisacetylacetonate [VO(acac)(2)] on beta cells upon treatment with palmitate, a typical saturated FFA. The experimental results showed that VO(acac)(2) could enhance FFA-induced signaling pathways of unfolded protein responses by upregulating the prosurvival chaperone immunoglobulin heavy-chain binding protein/78-kDa glucose-regulated protein and downregulating the expression of apoptotic C/EBP homologous protein, and consequently the reduction of insulin synthesis. VO(acac)(2) also ameliorated FFA-disturbed Ca(2+) homeostasis in beta cells. Overall, VO(acac)(2) enhanced stress adaption, thus protecting beta cells from palmitate-induced apoptosis. This study provides some new insights into the mechanisms of antidiabetic vanadium compounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据