Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2012) B. Cameron et al.   JOURNAL OF NEUROSCIENCE

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

The Critical Role of IL-1 Receptor-Associated Kinase 4-Mediated NF- B Activation in Modified Low-Density Lipoprotein-Induced Inflammatory Gene Expression and Atherosclerosis

(2011) T. W. Kim et al.   JOURNAL OF IMMUNOLOGY

Immune Complex-Mediated Cell Activation from Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients Elaborate Different Requirements for IRAK1/4 Kinase Activity across Human Cell Types

(2010) E. Y. Chiang et al.   JOURNAL OF IMMUNOLOGY

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation

(2009) Magdalena Koziczak-Holbro et al.   ARTHRITIS AND RHEUMATISM

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease

(2009) K. A. Staschke et al.   JOURNAL OF IMMUNOLOGY

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells

(2009) Kyung W. Song et al.   MOLECULAR IMMUNOLOGY

Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling

(2008) Martin C. Moncrieffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Toll-like Receptor-induced TAK1-dependent NFκB Activation

(2008) Jerzy Frączek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE