Article
Biochemistry & Molecular Biology
Zhenyang Shen, Weiming Dai, Yuecheng Guo, Junjun Wang, Bo Shen, Binghang Li, Lungen Lu, Xiaobo Cai
Summary: Liver fibrosis is associated with the expansion and differentiation of liver progenitor cells (LPCs). YAP plays a crucial role in regulating LPCs proliferation and differentiation during liver fibrosis, and manipulating YAP expression in LPCs may present a potential treatment for chronic liver diseases.
Article
Medicine, General & Internal
Antonio Lo Nigro, Alessia Gallo, Matteo Bulati, Giampiero Vitale, Diego Sebastian Paini, Mariangela Pampalone, Daniele Galvagno, Pier Giulio Conaldi, Vitale Miceli
Summary: The global prevalence of end-stage liver diseases is high, with liver transplantation being the main treatment option. Research on alternative therapies, such as cell therapy, is ongoing.
FRONTIERS IN MEDICINE
(2021)
Article
Cell & Tissue Engineering
Yuting Lin, Fang Zhang, Ludi Zhang, Lian Chen, Shan Zheng
Summary: This study investigates the characteristics of SOX9-positive liver progenitor-like cells (LPLCs) in Biliary Atresia (BA) and finds that LPLCs are associated with disease progression and prognostic factors. LPLCs have superior proliferation and anti-senescence ability under cholestasis conditions and continuously differentiate into reactive ductular cells (RDCs) from hepatocytes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Jian Huang, Bi-Jun Qiu, Xiao-Shu Qi, Cai-Yang Chen, Wen-Ming Liu, Shen-ao Zhou, Min Ding, Feng-Feng Lu, Jie Zhao, Dan Tang, Xu Zhou, Gong-Bo Fu, Zhen-Yu Wang, Hong-Qian Ma, Yu-Ling Wu, Hong-ping Wu, Xiao-Song Chen, Wei-Feng Yu, He-Xin Yan
Summary: The study reveals the involvement of CD24(+)LCN2(+) liver progenitor cells (LPCs) in the expanding ductular reaction and the macrophage-mediated inflammation in chronic liver damage. The findings highlight the roles of LPCs from different origins and expose the possibility of targeting LPCs in the treatment of chronic hepatic diseases.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Arnav Chhabra, H-H Greco Song, Katarzyna A. Grzelak, William J. Polacheck, Heather E. Fleming, Christopher S. Chen, Sangeeta N. Bhatia
Summary: This study developed a 3D platform for modeling human liver regeneration and found that endothelial cell secretion and cytokine stimulation can promote hepatocyte proliferation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Valentin J. A. Barthet, Martina Brucoli, Marcus J. G. W. Ladds, Christoph Nossing, Christos Kiourtis, Alice D. Baudot, James O'Prey, Barbara Zunino, Miryam Muller, Stephanie May, Colin Nixon, Jaclyn S. Long, Thomas G. Bird, Kevin M. Ryan
Summary: The study presents a genetically engineered mouse model of HCC driven by loss of autophagy and hemizygosity of PTEN, showing the involvement of ductular reaction in HCC development. Following loss of autophagy, mature hepatocytes dedifferentiate into biliary-like liver progenitor cells, leading to HCC. Deletion of YAP and TAZ transcription factors reverses the dedifferentiation and tumorigenesis, suggesting new potential targets for therapeutic intervention.
Article
Veterinary Sciences
Yanad Abou Monsef, Osman Kutsal
Summary: Hepatic progenitor cells play a significant role in the regeneration of the feline liver, with the activation pattern of ductular reaction varying according to the type of hepatobiliary disease. The study highlights the presence of progenitor cells in normal and diseased livers, as well as the different locations of ductular reaction in various hepatic diseases.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Review
Gastroenterology & Hepatology
Ru Huang, Xin Zhang, Jordi Gracia-Sancho, Wei-Fen Xie
Summary: This review summarizes recent studies on the mechanisms of liver regeneration, including the cellular origin of newly generated hepatocytes and the underlying mechanisms, which are of great significance in the treatment of liver diseases.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Konstantina Kyritsi, Lindsey Kennedy, Vik Meadows, Laura Hargrove, Jennifer Demieville, Linh Pham, Amelia Sybenga, Debjyoti Kundu, Karla Cerritos, Fanyin Meng, Gianfranco Alpini, Heather Francis
Summary: The study demonstrates that reintroduction of MCs through TGF-beta 1 promotes cholestatic liver injury characterized by fibrosis, angiogenesis, and ductular reaction. However, blocking TGF-beta 1 with TGF-beta Ri can reverse these pathological processes.
Article
Cell Biology
Jue Wang, Ping Situ, Sen Chen, Haibin Wu, Xueyan Zhang, Shoupei Liu, Yiyu Wang, Jinghe Xie, Honglin Chen, Yuyou Duan
Summary: The study found that polarized differentiation enhances the maturity and liver function of human embryonic stem cell-derived hepatocytes (hEHs), and identifies molecular targets that regulate the polarization state of hEHs.
Article
Gastroenterology & Hepatology
Yu Huang, Daisuke Miyamoto, Pei-Lin Li, Yusuke Sakai, Takanobu Hara, Tomohiko Adachi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Wei-Li Gu, Susumu Eguchi
Summary: In an aging society, understanding the impact of hepatocyte age on liver donation can help expand alternative cell sources to address liver donor shortages. Research has shown that aged rat hepatocytes still have reprogramming potential, as they can be converted into CLiP cells expressing progenitor cell markers, although their proliferative rate is lower compared to young hepatocytes. Furthermore, treatment with hepatocyte growth factor (HGF) can promote proliferation and CLiP conversion in aged hepatocytes, suggesting that hepatocytes from aged donors may serve as a viable alternative cell source.
HEPATOLOGY RESEARCH
(2021)
Article
Medicine, General & Internal
Katalin Dezso, Sandor Paku, Laszlo Kobori, Snorri S. Thorgeirsson, Peter Nagy
Summary: Several studies have shown that liver fibrosis and cirrhosis can be reversed, proving the old dogma of cirrhosis being irreversibile wrong. Vascular alterations and specific structural changes play crucial roles in the progression of chronic liver diseases. To overcome cirrhosis, it is important to understand the factors that make it irreversible in certain cases.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Nerea Lazcanoiturburu, Juan Garcia-Saez, Carlos Gonzalez-Corralejo, Cesareo Roncero, Julian Sanz, Carlos Martin-Rodriguez, M. Pilar Valdecantos, Adoracion Martinez-Palacian, Laura Almale, Paloma Bragado, Silvia Calero-Perez, Almudena Fernandez, Maria Garcia-Bravo, Carmen Guerra, Lluis Montoliu, Jose Carlos Segovia, Angela M. Valverde, Isabel Fabregat, Blanca Herrera, Aranzazu Sanchez
Summary: Inactivating EGFR signaling in the liver can reduce liver damage and promote efficient regeneration following cholestatic injury. This effect involves enhanced activation of mitogenic/survival signals and changes in cell turnover, which are associated with differences in the profile of intrahepatic immune cells.
JOURNAL OF PATHOLOGY
(2022)
Review
Cell Biology
Toshihiro Mitaka, Norihisa Ichinohe, Naoki Tanimizu
Summary: Mature hepatocytes in the liver can be categorized into three subpopulations based on their proliferative capability: type I, type II, and type III cells. Small hepatocytes (SHs) are unique cells that appear in the liver and may play a role in liver regeneration. They can be derived from hepatocytic progenitors and are involved in the liver's development and growth.
Review
Biochemistry & Molecular Biology
Yan Li, Lungen Lu, Xiaobo Cai
Summary: Liver transplantation is the only curative option for end-stage liver disease, but limitations exist, prompting the need for research into alternative options. Liver regeneration, divided into hepatocyte-driven and liver progenitor cell-driven categories, shows promise as a therapeutic strategy for end-stage liver disease.
Article
Cell & Tissue Engineering
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Junko Kon, Yusuke Yoshioka, Takahiro Ochiya, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka
Article
Cell Biology
Naoki Tanimizu, Toshihiro Mitaka
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2017)
Article
Developmental Biology
Naoki Tanimizu, Norihisa Ichinohe, Toshihiro Mitaka
Article
Multidisciplinary Sciences
Naoki Tanimizu, Norihisa Ichinohe, Masahiro Yamamoto, Haruhiko Akiyama, Yuji Nishikawa, Toshihiro Mitaka
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Masayuki Ishii, Junichi Kino, Norihisa Ichinohe, Naoki Tanimizu, Takafumi Ninomiya, Hiromu Suzuki, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Naoki Tanimizu, Norihisa Ichinohe, Hiromu Suzuki, Toshihiro Mitaka
Article
Multidisciplinary Sciences
Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Summary: The study reports the generation of a hepatobiliary tubular organoid (HBTO) using mouse hepatocyte progenitors and cholangiocytes, which can reproduce the functional connection between hepatocytes and cholangiocytes in liver tissue.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka
Summary: The study found that miR-146a-5p in EVs produced by BM-MCs may play a major role in accelerating liver regeneration by activating intrinsic hepatocytic progenitor cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka
Summary: This study found that transplantation of -Thy1(+) cells isolated from rats treated with d-galactosamine can promote SHPC expansion and liver regeneration. This is achieved through the secretion of extracellular vesicles (EVs) by -Thy1(+) cells that induce sinusoidal endothelial cells and Kupffer cells to secrete IL17B and IL25, respectively, thereby activating SHPCs via IL17RB signaling. In addition, miR-199a-5p, CINC-2, and MCP-1 in the Thy1(-) cell-derived EVs are potential factors promoting SHPC growth.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Gastroenterology & Hepatology
Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, Hiromu Suzuki, Toru Mizuguchi, Naoki Tanimizu, Toshihiro Mitaka
HEPATOLOGY COMMUNICATIONS
(2020)