Article
Immunology
Yuan Gao, Zhenlu Xu, Ximeng Li, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Xiaoyu Zhang, Yun Qi
Summary: Resibufogenin (RBG), one of the major active components in toad venom, has significant anti-inflammatory activity by reducing inflammatory mediators and inhibiting NF-kappa B and AP-1 signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Man Liu, Ying-Lin Yang, Shan-Shan Zhang, Dong-Ni Liu, Lian-Hua Fang, Guan-Hua Du, Yue-Hua Wang
Summary: The study revealed that RKC-B1 exhibits anti-neuroinflammatory effects in LPS-stimulated mice by modulating multiple inflammatory signaling pathways, suggesting it could be a promising agent for treating neuroinflammation.
Article
Pharmacology & Pharmacy
Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang
Summary: Koumine inhibits NLRP3 inflammasome activation and reduces neutrophil infiltration and IL-1β production, both in vitro and in vivo. The inhibitory effect involves blocking the ROS/NF-kappa B/NLRP3 signal axis, suggesting potential clinical applications for NLRP3 inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin
Summary: This study investigated the pathophysiological role of BRISC in acute liver failure. The expression of BRISC components was found to increase in kupffer cells (KCs) upon LPS treatment, and the deficiency of BRISC significantly attenuated liver damage and inflammation response. The study demonstrated that BRISC is involved in NF-kappa B-mediated proinflammatory cytokines production in LPS-treated KCs. This research opens the possibility for the development of new strategies to inhibit KCs-driven inflammation in liver diseases.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Hye Suk Baek, Victor Sukbong Hong, Sang Hyon Kim, Jinho Lee, Shin Kim
Summary: KMU-1170 inhibits inflammatory signal transduction by targeting multiple protein kinases, demonstrating potential as an anti-inflammatory agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shuaibing Hou, Xiaomin Wang, Tengxiao Guo, Yanjie Lan, Shengnan Yuan, Shuang Yang, Fei Zhao, Aizhong Fang, Na Liu, Wanzhu Yang, Yajing Chu, Erlie Jiang, Tao Cheng, Xiaojian Sun, Weiping Yuan
Summary: This study reveals that PHF6 plays a significant role in myeloid leukemia by inhibiting NF-κB signaling pathway to suppress cell proliferation and induce apoptosis. The authors also discovered that PHF6 acts as a tumor suppressor gene in lymphocytic leukemia but as an oncogene in myeloid leukemia.
Article
Immunology
Luyao Yang, Hongqing Chen, Qiongying Hu, Lu Liu, Yun Yuan, Chuantao Zhang, Jianyuan Tang, Xiaofei Shen
Summary: This study found that eupalinolide B (EB) derived from Eupatorium lindleyanum effectively alleviated acute lung injury (ALI) in mice by inhibiting the activation of TAK1 and its downstream NF-κB and MAPKs pathways, leading to reduced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
Summary: The noncanonical NF-kappa B signaling pathway plays a crucial role in regulating inflammation and immune response, showing potential therapeutic value against liver diseases. Activation of this pathway may contribute to viral clearance, with specific inhibitors and antibodies currently under development and testing.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xingchi Kan, Yingsheng Chen, Bingxu Huang, Shoupeng Fu, Wenjin Guo, Xin Ran, Yu Cao, Dianwen Xu, Ji Cheng, Zhanqing Yang, Yanling Xu
Summary: The study found that Palmatine significantly inhibits the expression and secretion of inflammatory cytokines, reducing the levels of proinflammatory enzyme iNOS. By inhibiting the activation of the Akt/NF-kappa B signaling pathway, Palmatine alleviates LPS-induced ALI.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Developmental Biology
Ziqian Min, Jingyu Wan, Huan Xin, Xiaowen Liu, Xinxu Rao, Ziling Fan, Lifang Yang, Dan Li
Summary: Bacterial infection can lead to testicular inflammation and male infertility. This study reveals the role of NR2C2 in macrophage cells in orchitis caused by bacterial endotoxin lipopolysaccharide (LPS) infection. NR2C2 activates the NF-kappa B pathway by binding with DR elements in the promotor of the Nf kappa b gene, promoting the development of inflammation. These findings provide a potential target for the treatment of male infertility caused by bacterial infection.
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Natasja A. Otto, Alex F. de Vos, Jeroen W. J. van Heijst, Joris J. T. H. Roelofs, Tom van der Poll
Summary: This study found that myeloid LKB1 plays an important role in maintaining an adequate number of alveolar macrophages (AMs) during pneumonia, while LKB1 deficiency in neutrophils has no effect. These findings reveal the mechanism of LKB1's role in innate immunity in the lungs.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Yun Yuan, Qiongying Hu, Lu Liu, Fan Xie, Luyao Yang, Yuchen Li, Chuantao Zhang, Hongqing Chen, Jianyuan Tang, Xiaofei Shen
Summary: This study found that Dehydrocostus lactone (DCL) has anti-inflammatory effects and can alleviate colitis symptoms by targeting NF-kappa B and Nrf2 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Changyong Lee, Sik Yoon, Jeon-Ok Moon
Summary: The study investigated the hepatoprotective effects of kaempferol, an antioxidant flavonoid found in edible vegetables, in rats with CCl4-induced acute liver damage. Kaempferol administration ameliorated liver abnormalities and inflammation, improved oxidative status, and activated protective signaling pathways. These findings suggest the potential therapeutic use of kaempferol for liver injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)