Article
Microbiology
Ningkun Liu, Yanzhuo Xu, Qi Li, Yuxin Cao, Dechang Yang, Shasha Liu, Xiaokang Wang, Yingjie Mi, Yang Liu, Chenxi Ding, Yan Liu, Yong Li, Yao-Wu Yuan, Ge Gao, Jinfeng Chen, Weiqiang Qian, Xiaoming Zhang
Summary: A long non-coding RNA called SABC1 has been discovered to play a crucial role in balancing plant immunity and growth. SABC1 suppresses plant immunity and promotes growth by regulating the neighboring gene NAC3. This lncRNA acts as a molecular switch in modulating the production of salicylic acid, a key molecule in plant defense against pathogens.
CELL HOST & MICROBE
(2022)
Article
Cell Biology
Jennifer L. Johnson, Mahalakshmi Ramadass, Farhana Rahman, Elsa Meneses-Salas, Nadia R. Zgajnar, Raquel Carvalho Gontijo, Jinzhong Zhang, William B. Kiosses, Yanfang Peipei Zhu, Catherine C. Hedrick, Marta Perego, Jenny E. Gunton, Kersi Pestonjamasp, Gennaro Napolitano, Sergio D. Catz
Summary: Deficiency of Gem enhances the neutrophil innate immune response by increasing NADPH oxidase assembly and NETs production, with macroautophagy differentially regulating ROS and NETs in neutrophils.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jack Rhodes, Huanjie Yang, Steven Moussu, Freddy Boutrot, Julia Santiago, Cyril Zipfel
Summary: The leucine-rich repeat receptor kinase MIK2 is identified as the receptor for the SCOOP family of phytocytokines, playing a crucial role in immune responses triggered by SCOOP peptides and recognizing SCOOP-like peptides derived from Fusarium. This discovery sheds light on the diverse functions of MIK2 in plant growth, development, and stress responses by perceiving secreted peptides and regulating immune responses against pathogens such as Fusarium.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Luis A. Arteaga-Blanco, Dumith Chequer Bou-Habib
Summary: The nanosized EVs released by cells play a crucial role in intercellular communication, regulating cellular homeostasis and potentially spreading pathogen-derived molecules. Studying EVs shed by human macrophages can provide insights into modulating host immune responses and developing innovative therapeutic strategies against infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Guy Sobol, Bharat Bhusan Majhi, Metsada Pasmanik-Chor, Ning Zhang, Holly M. Roberts, Gregory B. Martin, Guido Sessa
Summary: A tomato protein called Fir1 interacts with the bacterial flagellin receptors Fls2 and Fls3, playing a role in pattern-triggered immunity. Fir1 is located in the plasma membrane and interacts with Fls2 and Fls3 in yeast and in tomato plants. Mutants lacking the fir1 gene showed impaired immune responses triggered by flagellin, including decreased resistance to Pseudomonas syringae pv. tomato (Pst) DC3000 and altered gene expression. This study highlights the importance of Fir1 in flagellin-triggered immunity.
Article
Plant Sciences
Yujia Li, Jiao Xue, Feng-Zhu Wang, Xiangjuan Huang, Ben-Qiang Gong, Yuheng Tao, Wenzhong Shen, Kehan Tao, Nan Yao, Shi Xiao, Jian-Min Zhou, Jian-Feng Li
Summary: Plants use cell-surface immune receptors to recognize pathogen-specific patterns and evoke basal immunity. Researchers have discovered that the fungal pattern chitin can induce nuclear translocation of PBL19 in Arabidopsis and its interaction with EDS1 in the cytoplasm. These findings reveal the important role of PBL19 in plant antifungal immunity.
Review
Immunology
Amy Dagenais, Carlos Villalba-Guerrero, Martin Olivier
Summary: Innate immune cells can enhance the response to reinfection through trained immunity, a form of immunological memory. The potential of trained immunity in prophylaxis and therapy has attracted great interest in the field of infectious diseases. In the context of antimicrobial resistance and climate change, harnessing the advantages of trained immunity could be game-changing. This article presents recent research linking trained immunity and infectious diseases, highlighting important discoveries, questions, concerns, and novel avenues for its modulation in practice, with a focus on problematic and understudied pathogens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Manuel Albert, Jesus Vazquez, Juan M. Falcon-Perez, Maria A. Balboa, Marc Liesa, Jesus Balsinde, Susana Guerra
Summary: This study reveals the role of ISG15 in regulating lipid metabolism in macrophages and its importance in the context of viral infections. The findings provide insights into macrophage immunometabolism and the interaction between poxviruses and the host.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cell Biology
Zhen-Zhen Liu, Wei Chen, Cheng-Kai Zhou, Ke Ma, Yu Gao, Yong-Jun Yang
Summary: This study revealed the importance of STING in promoting extracellular traps (ETs) formation through the ROS-ERK signaling pathway during Staphylococcus aureus infection. STING deficiency led to decreased cell-free DNA (cfDNA) level, reduced expression of citrullinated histone H3 (CitH3), and diminished DNA colocalization with CitH3 and myeloperoxidase (MPO). Additionally, STING(-/-) BMDMs exhibited increased levels of extracellular bacteria compared to WT BMDMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
Yuelian Zou, Xin Xu, Qilin Hu, Yilei Wang, Huiping Yang, Ziping Zhang
Summary: This study identified and analyzed the FREP genes in abalones, revealing their important role in the immune system and significance for disease prevention and control in aquaculture species.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Jiaojiao He, Hanjie Gu, Wenqi Wang, Yonghua Hu
Summary: "CD9 homologs PoCD9.1 and PoCD9.3 in Japanese flounder play a crucial role in the immune response to pathogenic infections, with distinct functions in response to different pathogens at various stages of infection."
VETERINARY RESEARCH
(2021)
Article
Microbiology
Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, Kristin L. Patrick, Robert O. Watson
Summary: Mycobacterium tuberculosis (Mtb) infection is a global health threat, and macrophages play a crucial role in the host defense against Mtb. Galectin-8 has been identified as a key player in recognizing damaged Mtb-containing phagosomes and targeting Mtb to selective autophagy, ultimately controlling Mtb replication in macrophages. The interaction between galectin-8 and TAX1BP1 is essential for efficient targeting of Mtb to selective autophagy, highlighting a potential target for host-directed tuberculosis therapies.
Article
Plant Sciences
Ran Wang, Chenying Li, Qinghong Li, Yingfei Ai, Zeming Huang, Xun Sun, Jie Zhou, Yanhong Zhou, Yan Liang
Summary: This study demonstrates that modifying the regulatory components of ROS production in plant immunity can lead to the engineering or breeding of broad-spectrum disease-resistant crops without affecting yield.
HORTICULTURE RESEARCH
(2022)
Article
Microbiology
Stephen A. Klotz, Nicole Bradley, Peter N. Lipke
Summary: The interactions between Candida and macrophages play a crucial role in the immune defense against disseminated and deep-seated candidiasis. This study reveals the significance of the interaction between serum amyloid P-component (SAP) and functional amyloids on Candida cells. Blocking the binding between SAP and macrophages enhances phagocytosis of yeast cells, while promoting amyloid formation on the yeast cell surface also increases phagocytosis by macrophages. Additionally, the use of miridesap, a small palindrome molecule, shows potential in boosting phagocytosis by preventing SAP binding to yeasts and removing bound SAP. These interventions have the potential to enhance the host immune response to disseminated candidiasis.