Article
Endocrinology & Metabolism
Gilvanildo Roberto da Silva, Mariane Gomes Carneiro, Miriam Pereira Barbosa, Jaciane de Almeida Costa, Ivone Antonia de Souza, Lisiane dos Santos Oliveira, Diogo Antonio Alves de Vasconcelos, Elizabeth do Nascimento, Rhowena Jane Barbosa Matos, Sandra Lopes de Souza, Manuela Figueiroa Lyra de Freitas
Summary: Obesogenic diets can induce obesity and changes in food intake, which negatively affect the neural aspects and peripheral metabolism. The combination of naltrexone/bupropion has potential in controlling metabolic alterations and modulating dopaminergic expression.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Diana Z. Paderina, Anastasiia S. Boiko, Ivan Pozhidaev, Irina A. Mednova, Anastasia A. Goncharova, Anna Bocharova, Olga Yu Fedorenko, Elena G. Kornetova, Arkadiy Semke, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: The study found that the functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia.
Article
Multidisciplinary Sciences
Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong -Min Yin
Summary: Olfactory behavior is crucial for animal survival, and olfactory dysfunction is commonly seen in various diseases. This study reveals that mature olfactory sensory neurons (OSNs) express high levels of dopamine D2 receptor (Drd2), which can modulate odorant recognition response by inhibiting odor-induced signaling. Furthermore, nasal dopamine and DRD2 receptor are identified as potential peripheral targets for olfactory modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Matthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Zhou Fang, Shuangyi Cai, Heng Pan, Muhammad Asad, Maria Laura Martin, Michael Sigouros, Florencia M. Rowdo, Sarah Ackermann, Jared Capuano, Jacob Bernheim, Cynthia Cheung, Ashley Doane, Nicholas Brady, Richa Singh, David S. Rickman, Varun Prabhu, Joshua E. Allen, Loredana Puca, Ahmet F. Coskun, Mark A. Rubin, Himisha Beltran, Juan Miguel Mosquera, Olivier Elemento, Ankur Singh
Summary: This study defined the role of ECM signals in the development of CRPC-NEPC and identified potential therapeutic targets for neuroendocrine prostate cancer. In animal models, strong anti-tumor responses were observed with the use of a DRD2 inhibitor, and a combination of epigenetic inhibitors and DRD2 treatment was shown to overcome therapeutic resistance in CRPC-NEPC under drug-resistant ECM conditions.
ADVANCED MATERIALS
(2022)
Review
Genetics & Heredity
Muhammad Saif-ur Rehman, Saif Ur Rehman, Wasim Yousaf, Faiz-ul Hassan, Waqas Ahmad, Qingyou Liu, Hongping Pan
Summary: Toll-like receptors (TLRs) are essential for regulating immune responses and disease resistance in chickens. By utilizing specific feed ingredients and yeast-derived products, the immunity and disease resistance of chickens can be enhanced, providing new avenues for healthy and profitable chicken production.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Antonio Del Casale, Maurizio Simmaco, Martina Nicole Modesti, Clarissa Zocchi, Jan Francesco Arena, Irene Bilotta, Alessandro Alcibiade, Giuseppe Sarli, Lorenzo Cutillo, Giulia Antonelli, Enrico La Spina, Ottavia De Luca, Robert Preissner, Marina Borro, Giovanna Gentile, Paolo Girardi, Maurizio Pompili
Summary: This study investigates the correlation between DRD2, DRD3, and HTR2A genes and resistance to antipsychotic medication, and finds that a diagnosis of schizophrenia and specific genotypes are significantly associated with high treatment resistance.
Article
Multidisciplinary Sciences
Sonali A. Deshpande, Ethan W. Rohrbach, James D. Asuncion, Jenna Harrigan, Aditya Eamani, Ellery H. Schlingmann, Daniel J. Suto, Pei-Tseng Lee, Felix E. Schweizer, Hugo J. Bellen, David E. Krantz
Summary: Octopamine plays an essential role in egg-laying in Drosophila melanogaster. This study identifies two octopamine receptors, Oct beta 2 and OAMB, that regulate oviduct contraction and relaxation, respectively. The interaction with glutamatergic pathways modifies the effects of octopamine, suggesting a possible mechanism for lateral oviduct contractions. The aminergic pathways in the oviposition circuit may be comparable to those that regulate visceral muscle contractility in mammals.
Article
Psychiatry
Xiuping Fu, Aparna P. Shah, Jacqueline Keighron, Ta-Chung M. Mou, Bruce Ladenheim, Jesse Alt, Daisuke Fukudome, Minae Niwa, Kellie L. Tamashiro, Gianluigi Tanda, Akira Sawa, Jean-Lud Cadet, Rana Rais, Jay M. Baraban
Summary: The study found that mice lacking the microRNA-degrading enzyme showed an exaggerated locomotor response to amphetamine and had higher brain levels of the drug, which correlated with adiposity. Diet-induced increases in adiposity also led to elevated brain levels of amphetamine in wild type mice.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Paula Soria-Chacartegui, Gonzalo Villapalos-Garcia, Pablo Zubiaur, Francisco Abad-Santos, Dora Koller
Summary: Olanzapine, aripiprazole, and risperidone are widely used for schizophrenia treatment and can induce various adverse drug reactions. The metabolism and individual genetic polymorphisms of these drugs affect pharmacokinetics and drug responses, necessitating consideration of patient genotypes and potential drug interactions during treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Maria Addolorata Mariggio, Roberto Palumbi, Angela Vinella, Riccardo Laterza, Maria Giuseppina Petruzzelli, Antonia Peschechera, Alessandra Gabellone, Ottavio Gentile, Alessandra Vincenti, Lucia Margari
Summary: The dopaminergic system may play a role in both ASD and ADHD, with DRD1 and DRD2 dopamine receptor SNPs potentially being risk factors for these disorders. Specifically, DRD2-12 was found to be significantly associated with the ASD/ADHD overlap, supporting the hypothesis of genetic neuromodulation in the neurobiology of these conditions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Agnieszka Jelen, Rafal Swiechowski, Marta Zebrowska-Nawrocka, Aleksandra Salagacka-Kubiak, Dagmara Szmajda-Krygier, Piotr Ga Lecki, Ewa Balcerczak
Summary: This study evaluated the association between ABCB1 gene polymorphism and depression, as well as the effectiveness of its treatment. The results showed that T-129C does not play an important role in rDD development, but other studied SNPs do have an additive impact on the course of depression and its treatment effectiveness.
Article
Endocrinology & Metabolism
Jamie A. Mullally, Wendy K. Chung, Charles A. LeDuc, Tirissa J. Reid, Gerardo Febres, Steven Holleran, Rajasekhar Ramakrishnan, Judith Korner
Summary: The study assessed the association between rs1800497 polymorphism near DRD2 and weight loss with NB treatment, showing that individuals with the A1+ genotype had significantly greater weight loss compared to those with the A1- genotype. This suggests that individuals carrying the A1+ allele may respond better to NB treatment than A1- individuals.
DIABETES OBESITY & METABOLISM
(2021)
Article
Health Care Sciences & Services
Wendao Liu, Noam Shomron
Summary: MicroRNAs regulate gene expression by binding to mRNAs, reducing target gene expression levels and noise. Single-cell RNA sequencing technology has been used to study miRNA and mRNA expression in single cells. However, technical noise from scRNA-seq can mask the effect of miRNAs on gene expression noise. Improvements in experimental design and computational analysis are necessary to reduce technical noise.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Genetics & Heredity
Stanislav Kotlyarov
Summary: Atherosclerosis is a significant medical and social issue, causing numerous hospitalizations, disabilities, and deaths. Inflammation plays a crucial role in the pathogenesis of atherosclerosis and is closely linked to lipid metabolism in the vascular wall. The role of genetics and epigenetic factors in the development of atherosclerosis is of great interest, particularly the relationship between gene polymorphism and dysregulated gene expression involved in lipid metabolism and the innate immune system. Understanding the genetic and molecular mechanisms of disease pathogenesis is essential for early diagnosis and treatment.
Article
Oncology
Guanglong Jiang, Jill L. Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu
Summary: This study investigated the cis-regulation of isomiR biogenesis in human lymphoblastoid cell lines and identified significant associations between SNPs and 5'-isomiRs. The study also revealed the association between specific SNPs and the extensions and trimmings of certain isomiRs. Furthermore, the study showed that isomiR expression is correlated with breast cancer status and highlighted the role of isomiRs in biological processes.