First Demonstration of Transmissible Spongiform Encephalopathy-associated Prion Protein (PrPTSE) in Extracellular Vesicles from Plasma of Mice Infected with Mouse-adapted Variant Creutzfeldt-Jakob Disease byin VitroAmplification

A highly specific blood test for vCJD

(2014) G. S. Jackson et al.   BLOOD

Re-Assessment of PrPSc Distribution in Sporadic and Variant CJD

(2014) Richard Rubenstein et al.   PLoS One

Population Screening for Variant Creutzfeldt-Jakob Disease Using a Novel Blood Test

(2014) Graham S. Jackson et al.   JAMA Neurology

Oxidation of Methionine 216 in Sheep and Elk Prion Protein Is Highly Dependent upon the Amino Acid at Position 218 but Is Not Important for Prion Propagation

(2013) Christopher J. Silva et al.   BIOCHEMISTRY

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Normal prion protein is expressed on exosomes isolated from human plasma

(2013) Adam J. Ritchie et al.   BRITISH JOURNAL OF HAEMATOLOGY

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

(2013) Hiroko Tadokoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

In Vitro Detection of prionemia in TSE-Infected Cervids and Hamsters

(2013) Alan M. Elder et al.   PLoS One

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

(2013) Hina Kalra et al.   PROTEOMICS

Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey

(2013) O. N. Gill et al.   BMJ-British Medical Journal

γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells

(2012) Irina Surgucheva et al.   BIOCHEMISTRY

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

(2012) Anja Schneider et al.   CELL AND TISSUE RESEARCH

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

(2012) Bradley M. Coleman et al.   FASEB JOURNAL

Blood-borne macrophage–neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery

(2012) Matthew J Haney et al.   Nanomedicine

Detection of Prion Protein Particles in Blood Plasma of Scrapie Infected Sheep

(2012) Oliver Bannach et al.   PLoS One

Medulloblastoma Exosome Proteomics Yield Functional Roles for Extracellular Vesicles

(2012) Laura M. Epple et al.   PLoS One

Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrPSc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

(2012) Sarah Vascellari et al.   PLoS One

Separate mechanisms act concurrently to shed and release the prion protein from the cell

(2012) Lotta Wik et al.   Prion

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection

(2012) Rocio Castro-Seoane et al.   PLoS Pathogens

Highly Efficient Prion Transmission by Blood Transfusion

(2012) Olivier Andréoletti et al.   PLoS Pathogens

Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

(2012) Valérie Vingtdeux et al.   Frontiers in Physiology

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Disease Detection, PMCA Kinetics, and IgG in Urine from Sheep Naturally/Experimentally Infected with Scrapie and Deer with Preclinical/Clinical Chronic Wasting Disease

(2011) R. Rubenstein et al.   JOURNAL OF VIROLOGY

Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay

(2011) Julie Ann Edgeworth et al.   LANCET

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

(2011) Ryuichiro Atarashi et al.   NATURE MEDICINE

All Clinically-Relevant Blood Components Transmit Prion Disease following a Single Blood Transfusion: A Sheep Model of vCJD

(2011) Sandra McCutcheon et al.   PLoS One

Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells

(2011) Larisa Cervenakova et al.   TRANSFUSION

Prion Disease Blood Test Using Immunoprecipitation and Improved Quaking-Induced Conversion

(2011) C. D. Orru et al.   mBio

Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism

(2010) Masayoshi Tasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

(2010) Yanze Li et al.   GENES TO CELLS

Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia

(2010) A. PEDEN et al.   HAEMOPHILIA

A novel method for preclinical detection of PrPSc in blood

(2010) R. Rubenstein et al.   JOURNAL OF GENERAL VIROLOGY

Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study

(2010) Jonathan DF Wadsworth et al.   JOURNAL OF PATHOLOGY

Large-scale immunohistochemical examination for lymphoreticular prion protein in tonsil specimens collected in Britain

(2010) Mar Fernandez de Marco et al.   JOURNAL OF PATHOLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Detection of proteinase K resistant proteins in the urine of patients with Creutzfeldt-Jakob and other neurodegenerative diseases

(2010) Reza Dabaghian et al.   Prion

Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification

(2010) M. Howard Tattum et al.   TRANSFUSION

The risk of transmitting prion disease by blood or plasma products

(2010) Richard Knight   TRANSFUSION AND APHERESIS SCIENCE

Variant Creutzfeldt-Jakob disease in France and the United Kingdom: Evidence for the same agent strain

(2009) Jean-Philippe Brandel et al.   ANNALS OF NEUROLOGY

Hyperefficient PrPScamplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique

(2009) Aiko Fujihara et al.   FEBS Journal

Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)

(2009) Mireya Gonzalez-Begne et al.   JOURNAL OF PROTEOME RESEARCH

Detection of PrPsc in Blood from Sheep Infected with the Scrapie and Bovine Spongiform Encephalopathy Agents

(2009) L. A. Terry et al.   JOURNAL OF VIROLOGY

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

(2009) Suresh Mathivanan et al.   MOLECULAR & CELLULAR PROTEOMICS

Paracrine Diffusion of PrPC and Propagation of Prion Infectivity by Plasma Membrane-Derived Microvesicles

(2009) Vincenzo Mattei et al.   PLoS One

Lack of evidence of transfusion transmission of Creutzfeldt-Jakob disease in a US surveillance study

(2009) Kerri Dorsey et al.   TRANSFUSION

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

(2008) Sandrine Alais et al.   BIOLOGY OF THE CELL

Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy

(2008) Nathalie M. Veith et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Detection of infectious prions in urine

(2008) Dennisse Gonzalez-Romero et al.   FEBS LETTERS

In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie

(2008) L. Thorne et al.   JOURNAL OF GENERAL VIROLOGY

Persistent Propagation of Variant Creutzfeldt-Jakob Disease Agent in Murine Spleen Stromal Cell Culture with Features of Mesenchymal Stem Cells

(2008) S. Akimov et al.   JOURNAL OF VIROLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY