Article
Immunology
Shan Lin, Qingui Chen, Lishan Zhang, Shanhui Ge, Yuling Luo, Wanmei He, Caixia Xu, Mian Zeng
Summary: Coculturing BMSCs overexpressing HOXB4 prevented LPS-induced EC injury by activating the Wnt/beta-catenin pathway, leading to enhanced modulation of pro-inflammatory and anti-inflammatory factors. Further in vivo studies are needed to confirm the potential of this strategy for treating ALI/ARDS.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Correction
Cell Biology
Quan-Jun Deng, Xiao-Feng Xu, Jing Ren
Summary: There was an error in the positive control group of Figure 8 in the original version of the article.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Zhihui Zhang, Yulin Kuang, Kui Ma, Yan Li, Xiaoming Liu, Yuru Shi, Xu Wu
Summary: This study investigates the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) overexpressing GCLc on acute lung injury (ALI). The results show that overexpression of GCLc in BMSCs can reduce oxidative stress, improve cell survival, and inhibit apoptosis. The anti-apoptotic effects of GCLc are mediated through the PI3K/AKT/Foxo1 pathway. In an ALI mouse model, GCLc-overexpressing BMSCs improve lung inflammation and pulmonary edema.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongli Chen, Yuanhao Cai, Shujie Sun, Zhenhua Pan, Zhibo Han, Pai Liu, Yi Liu
Summary: This study investigated the role of photobiomodulation (PBM) in stem cell therapy for acute lung injury (ALI). The results showed that PBM enhanced the antioxidant capacity of stem cells and improved cell survival, effectively alleviating the pathological damage of ALI.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jianing Tan, Ziliang Zhuo, Xiuyu Wang, Yanshuang Zhang, Yucheng Qian, Fangfang Lin
Summary: The present study aimed to explore the anti-inflammatory properties of neural crest-derived EMSCs and their potential in treating acute lung injury (ALI). The results showed that EMSC-Sec had great anti-inflammatory potential and could effectively mitigate LPS-induced lung injury. This was achieved through the regulation of the NF-kappa B(p50/p65)/NLRP3 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Immunology
Mei-Chuan Chen, Kevin Shu-Leung Lai, Ko-Ling Chien, Sing Teck Teng, Yuh-Rong Lin, Wei Chao, Meng-Jung Lee, Po-Li Wei, Yen-Hua Huang, Han-Pin Kuo, Chih-Ming Weng, Chun-Liang Chou
Summary: This study found that pc-MSC therapy in severely ill COVID-19 patients can promote adaptive immune responses, reduce inflammatory responses, and improve clinical outcomes without adverse effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Laetitia Pouzol, Anna Sassi, Nadege Baumlin, Melanie Tunis, Daniel S. Strasser, Francois Lehembre, Marianne M. Martinic
Summary: The loss of control in immune cell trafficking to inflamed lung tissue leads to ALI/ARDS. The paper investigates the pathological role of the CXCR3/CXCR4/CXCR7 axis in a murine model of ALI. The study suggests the clinical potential of the CXCR7 antagonist, ACT-1004-1239, in reducing inflammation and improving lung function in ALI/ARDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yanping Xu, Jiaqi Zhu, Bing Feng, Feiyan Lin, Jiahang Zhou, Jingqi Liu, Xiaowei Shi, Xuan Lu, Qiaoling Pan, Jiong Yu, Ying Zhang, Lanjuan Li, Hongcui Cao
Summary: The study found that MSC transplantation significantly improved the survival rate of mice with ALI, alleviated lung damage, improved intestinal barrier integrity, and reduced inflammatory cytokines levels in both lung and gut. MSCs also inhibited the inflammatory response by decreasing CD8(+) T cells infiltration in the intestines, and altered gut bacterial community diversity.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Yuxuan Wu, Hao Sun, Lianju Qin, Xiaomin Zhang, Hao Zhou, Yao Wang, Lumin Wang, Meng Li, Jiayin Liu, Jinsong Zhang
Summary: This study aimed to determine the effects of human amnion-derived mesenchymal stem cells (hAMSCs) on two different acute lung injury (ALI) mice models. The high-dose hAMSCs group significantly alleviated alveolar-capillary permeability, oxidative stress, inflammatory factors level, and histopathological damage. The therapeutic effect of hAMSCs might involve NF-kappa B signaling pathway inhibition.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Cell & Tissue Engineering
Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su, Jian Zhou, Huayin Li, Yuanlin Song
Summary: The study found that MSC SLP significantly promoted cell survival, inhibited epithelial cell apoptosis, attenuated inflammatory cell recruitment, and reversed immunological imbalances induced by bleomycin in ALI. MSC SLP ameliorated ALI by activating p63 and promoting p63(+) cell proliferation and the repair of damaged epithelial cells. The findings suggest that MSC SLP shows considerable therapeutic promise for treating ALI and ARDS.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Bing Feng, Xudong Feng, Yingduo Yu, Haoying Xu, Qingqing Ye, Ruitian Hu, Xinru Fang, Feiqiong Gao, Jian Wu, Qiaoling Pan, Jiong Yu, Guanjing Lang, Lanjuan Li, Hongcui Cao
Summary: This study reveals the immunosuppressive effects of MSCs on neutrophils in acute lung injury, with MSC treatment shifting activated neutrophils towards an aged neutrophil phenotype to inhibit inflammation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Young Eun Kim, Dong Kyung Sung, Yuna Bang, Se In Sung, Misun Yang, So Yoon Ahn, Yun Sil Chang
Summary: Mesenchymal stem cells (MSCs) have immunomodulatory properties and can be used as therapeutic agents for inflammatory diseases. The suppressor of cytokine signaling (SOCS) proteins play a key role in macrophage modulation in MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Meng Deng, Jing He, Changfu Hao, Yonghua Guo, Huifang Si, Xuedan Deng, Chengpeng Zhang, Shiyu Li, Sanqiao Yao, Wenjie Ren, Wu Yao
Summary: This study investigates the effect of bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs (BMSCs-Exo) on blast lung injuries (BLIs) caused by gas explosion in rats. The findings demonstrate that BMSCs and BMSCs-Exo significantly reduce oxidative stress and inflammatory infiltration in the lungs. Additionally, they regulate apoptosis, autophagy, and pyroptosis, suggesting their potential in attenuating BLI.
Review
Cell & Tissue Engineering
Shiying Niu, Yueying Zhang
Summary: RILI, a common complication of radiotherapy, lacks effective therapeutic strategies. Studies show that MSCs can enhance tissue regeneration, modulate inflammatory response, and inhibit fibrotic cytokines, providing new potential therapeutic options for RILI.
STEM CELL RESEARCH & THERAPY
(2021)