Article
Immunology
Michal Zygarowicz, Joanna Kacperczyk-Bartnik, Janusz Sierdzinski, Cezary Wojtyla, Piotr Pierzynski, Grzegorz Manka, Mariusz Kiecka, Robert Z. Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Ewa Koc-Zorawska, Marcin Zorawski, Piotr Laudanski
Summary: This study investigated and compared the concentration of the protein annexin A2 (ANXA2) in plasma and peritoneal fluid in women with endometriosis compared to controls. The results showed that women with endometriosis had significantly higher levels of ANXA2 in their plasma compared to women without endometriosis. However, there were no significant differences in ANXA2 levels in the peritoneal fluid. Additionally, plasma concentrations of ANXA2 were significantly higher in patients with stage III and IV endometriosis compared to controls. Further studies are needed to confirm the role of ANXA2 in the pathogenesis of endometriosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Tanja Rothgangl, Melissa K. Dennis, Paulo J. C. Lin, Rurika Oka, Dominik Witzigmann, Lukas Villiger, Weihong Qi, Martina Hruzova, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, Sabina Egli, Nina Frey, Noelle Bakker, John A. Walker, Anastasia P. Kadina, Denis V. Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, Andreas Moor, Martin Jinek, Drew Weissman, Markus Stoffel, Ruben van Boxtel, Kevin Holden, Norbert Pardi, Beat Thoeny, Johannes Haeberle, Ying K. Tam, Sean C. Semple, Gerald Schwank
Summary: ABEs have been shown to effectively and safely reduce LDL levels in the livers of mice and cynomolgus macaques. Using lipid nanoparticle-based delivery of mRNA encoding an ABE and a sgRNA targeting PCSK9, significant reductions in PCSK9 and LDL levels were achieved in both species. Further research is warranted to explore the potential of ABEs in treating monogenic liver diseases.
NATURE BIOTECHNOLOGY
(2021)
Article
Neurosciences
Chin-Hung Hsu, Yi-Ju Pan, Yin-Ting Zheng, Raymond Y. Lo, Feng-Yi Yang
Summary: This study investigated the effects of low-intensity pulsed ultrasound (LIPUS) on M1/M2 polarization of microglial cells and the regulatory mechanisms associated with signaling pathways. The results showed that LIPUS treatment attenuated inflammatory markers and enhanced M2-related markers, switching microglial cells from the M1 to the M2 phenotype.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Amira F. Mahdi, Joanne Nolan, Ruth i. O'Connor, Aoife J. Lowery, Joanna M. Allardyce, Patrick A. Kiely, Kieran McGourty
Summary: The extracellular matrix (ECM) plays a significant role in the development and progression of breast cancer, and Annexin A2 has been identified as a key protein in this process. This study demonstrates that the presence of collagen-I in the ECM leads to the phosphorylation and translocation of Annexin A2, and identifies fibronectin as a novel interactor of Annexin A2. Furthermore, reducing Annexin A2 expression decreases the degradation of fibronectin by cancer cells, with this effect being influenced by collagen-I levels.
FRONTIERS IN ONCOLOGY
(2023)
Article
Plant Sciences
Dejan Dziubek, Louis Poeker, Beata Siemiatkowska, Alexander Graf, Giada Marino, Saleh Alseekh, Stephanie Arrivault, Alisdair R. Fernie, Ute Armbruster, Peter Geigenberger
Summary: This study investigated the effects of different light environmental factors on the long-term and short-term acclimation responses of Arabidopsis and the importance of the chloroplast redox network in their regulation. The results revealed that light intensity is a stronger driving factor for acclimation than variability. NTRC and thioredoxins m1/m2 play key roles in modulating light acclimation at the proteome and metabolome levels.
Article
Medicine, Research & Experimental
Celio Junior da Costa Fernandes, Kellen Cristina da Cruz Rodrigues, Diego Gomes de Melo, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: Obesity can lead to systemic inflammation and increased infiltration of pro-inflammatory macrophages in white adipose tissue (WAT), while decreasing anti-inflammatory macrophages. This study investigated the effects of strength training on macrophage polarization in WAT of obese mice. Results showed that both 7-day and 15-day strength training regimens improved insulin sensitivity by increasing AKT phosphorylation. Furthermore, 15 days of strength exercise reduced the M1/M2 ratio of macrophages in WAT.
Article
Immunology
Yoonsung Hu, Nogi Park, Keun Seok Seo, Joo Youn Park, Radha P. Somarathne, Alicia K. Olivier, Nicholas C. Fitzkee, Justin A. Thornton
Summary: The study reveals that pneumococcal surface adhesin A interacts with host cellular receptor ANXA2, indicating the importance of ANXA2 in pneumococcal colonization.
Article
Biochemistry & Molecular Biology
Li Cao, Qinghai Tan, Rui Zhu, Lanxiang Ye, Gaiping Shi, Zhenglin Yuan
Summary: Inhibition of MIR4435-2HG suppresses M1 polarization and promotes M2 polarization of macrophages, thereby alleviating intestinal inflammation in mice with ulcerative colitis through the JAK1/STAT1 signaling pathway.
Review
Integrative & Complementary Medicine
Amirhossein Sahebkar, Niki Katsiki, Natalie Ward, Zeljko Reiner
Summary: The meta-analysis of randomized controlled trials showed that supplementation with flaxseed-containing products can significantly decrease plasma Lp(a) levels, indicating the potential clinical significance of flaxseed supplementation for high residual CVD risk patients, hyperliporoteinemia(a) patients, and those who prefer natural remedies for CVD prevention. Further RCTs are needed to confirm the role of flaxseed-containing products in lowering Lp(a).
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Azar Hosseini, Vafa Baradaran Rahimi, Hassan Rakhshandeh, Vahid Reza Askari
Summary: This study evaluated the anti-inflammatory and protective properties of N. sativa oil on microglial cells and their polarization. The results showed that N. sativa oil reduced inflammation and increased the anti-inflammatory status of microglia.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Neurosciences
Yexiang Du, Min Luo, Yehong Du, Mingliang Xu, Qiuhui Yao, Kejian Wang, Guiqiong He
Summary: Our study demonstrated that liquiritigenin can alleviate Alzheimer's disease symptoms through multiple mechanisms, including reducing neuronal apoptosis, alleviating inflammation response, and promoting microglial type transformation. Furthermore, liquiritigenin may potentially treat AD by decreasing Aβ levels and improving spatial learning and memory.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Qiuping Zhou, Lanfen Lin, Haiyan Li, Huifang Wang, Shuqi Jiang, Peixian Huang, Qiongyu Lin, Xuan Chen, Yiyu Deng
Summary: Melatonin has the potential to reduce neurobehavioral disturbances and dampen microglia-mediated inflammation in LPS-injected rats. It can shift M1 microglia towards M2 phenotype, leading to a decrease in proinflammatory mediators and an increase in anti-inflammatory mediators. The therapeutic strategy of using melatonin to modulate microglial polarization may contribute to the attenuation of periventricular white matter damage.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Rheumatology
Shigeo Yoshida, Kohei Nishitani, Hiroyuki Yoshitomi, Shinichi Kuriyama, Shinichiro Nakamura, Takayuki Fujii, Motoo Saito, Yu Kobori, Akinori Murakami, Koichi Murata, Hiromu Ito, Hideki Ueno, Shuichi Matsuda
Summary: This study aimed to investigate the impact of high tibial osteotomy (HTO) on the intraarticular microenvironment of osteoarthritic (OA) knees. The results showed that HTO attenuated synovial inflammation and changed macrophage polarization, suggesting an improved intraarticular environment.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Himmet Haluk Akar, Yakup Cag, Mehmet Yasar Ozkars, Mikdat Yildiz
Summary: This study investigated serum ANXA2 levels in children with atopic dermatitis (AD) and found significantly lower levels in the disease group compared to the control group. This suggests a potential role for ANXA2 as an anti-inflammatory mediator in the pathogenesis of AD in children, which may be considered in the development of novel therapeutic approaches for AD patients.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2021)