Inhibition of Isoleucyl-tRNA Synthetase as a Potential Treatment for Human African Trypanosomiasis

Trypanosome cdc2-Related Kinase 9 Controls Spliced Leader RNA cap4 Methylation and Phosphorylation of RNA Polymerase II Subunit RPB1

(2013) N. Badjatia et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

High-throughput decoding of antitrypanosomal drug efficacy and resistance

(2012) Sam Alsford et al.   NATURE

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

(2012) Sam Alsford et al.   NUCLEIC ACIDS RESEARCH

Early Invasion of Brain Parenchyma by African Trypanosomes

(2012) Ute Frevert et al.   PLoS One

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

(2012) Cho Yeow Koh et al.   STRUCTURE

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicing

(2011) Jochen Rettig et al.   NUCLEIC ACIDS RESEARCH

High Prevalence of Drug Resistance in Animal Trypanosomes without a History of Drug Exposure

(2011) Simbarashe Chitanga et al.   PLoS Neglected Tropical Diseases

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Potential new drugs for human African trypanosomiasis: some progress at last

(2010) Michael P Barrett   CURRENT OPINION IN INFECTIOUS DISEASES

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

(2010) Julie A. Frearson et al.   NATURE

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

The other nanotech

(2009)   Nature Nanotechnology

The Burden of Human African Trypanosomiasis

(2009) Eric M. Fèvre et al.   PLoS Neglected Tropical Diseases

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

[3′-32P]-labeling tRNA with nucleotidyltransferase for assaying aminoacylation and peptide bond formation

(2008) Sarah Ledoux et al.   METHODS

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?

(2008) Pere P Simarro et al.   PLOS MEDICINE