期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 288, 期 19, 页码 13592-13601出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M112.429738
关键词
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资金
- Ministry of Education, Science, Sports, and Culture of Japan
- global COE (Center of Excellence) program for Network Medicine, Tohoku University
- Biomedical Research Core of Tohoku University School of Medicine
- Grants-in-Aid for Scientific Research [23790321, 23249085] Funding Source: KAKEN
Methionine adenosyltransferase (MAT) synthesizes S-adenosylmethionine (AdoMet), which is utilized as a methyl donor in transmethylation reactions involving histones. MATII alpha, a MAT isozyme, serves as a transcriptional corepressor in the oxidative stress response and forms the AdoMet-integrating transcription regulation module, affecting histone methyltransferase activities. However, the identities of genes regulated by MATII alpha or its associated methyltransferases are unclear. We show that MATII alpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1, thereby promoting the trimethylation of H3K9 at the COX-2 locus. We discuss both gene-specific and epigenome-wide functions of MATII alpha.
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