Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells

(2012) John M. Ashton et al.   Cell Stem Cell

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

(2012) Arya Sobhakumari et al.   PLoS One

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

(2012) D. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melampomagnolide B: A new antileukemic sesquiterpene

(2011) Shama Nasim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

(2011) S. A. Rushworth et al.   CANCER RESEARCH

Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

(2011) Vivek Bhakta Mathema et al.   INFLAMMATION

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Achieving reliability and high accuracy in automated protein docking: Cluspro, PIPER, SDU, and stability analysis in CAPRI rounds 13-19

(2010) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Selection of suitable housekeeping genes for expression analysis in glioblastoma using quantitative RT-PCR

(2009) Valeria Valente et al.   BMC MOLECULAR BIOLOGY

Apoptosis and glutathione: beyond an antioxidant

(2009) R Franco et al.   CELL DEATH AND DIFFERENTIATION

Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

(2009) Z. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

(2008) D. C. Hassane et al.   BLOOD

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

(2008) Beata Pajak et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

(2008) Christopher C. Franklin et al.   MOLECULAR ASPECTS OF MEDICINE

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY