Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State

Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation

(2012) Amar M. Singh et al.   Cell Stem Cell

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion

(2012) P. N. G. Pereira et al.   DEVELOPMENT

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression

(2012) R. Osorno et al.   DEVELOPMENT

The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells

(2012) N. Tsuneyoshi et al.   GENES & DEVELOPMENT

Transforming Growth Factor   Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes

(2012) E. Gronroos et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Smad Competition Controls Activin Receptor Output in Drosophila

(2012) Aidan J. Peterson et al.   PLoS One

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

(2011) Andreia S. Bernardo et al.   Cell Stem Cell

FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation

(2011) Pengzhi Yu et al.   Cell Stem Cell

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

FGF signalling inhibits neural induction in human embryonic stem cells

(2011) Boris Greber et al.   EMBO JOURNAL

Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism

(2010) Daniel M. Messerschmidt et al.   DEVELOPMENTAL BIOLOGY

Nodal Signaling Regulates the Bone Morphogenic Protein Pluripotency Pathway in Mouse Embryonic Stem Cells

(2010) Katherine E. Galvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

(2009) Yasuhide Ohinata et al.   CELL

Cross-regulation of the Nanog and Cdx2 promoters

(2009) Lingyi Chen et al.   CELL RESEARCH

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Activin/Nodal signalling maintains pluripotency by controlling Nanog expression

(2009) L. Vallier et al.   DEVELOPMENT

Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo

(2009) Masamichi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Activin/Nodal Inhibition Alone Accelerates Highly Efficient Neural Conversion from Human Embryonic Stem Cells and Imposes a Caudal Positional Identity

(2009) Rickie Patani et al.   PLoS One

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/ -catenin, Activin/Nodal and BMP signaling

(2008) T. Sumi et al.   DEVELOPMENT

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4

(2008) M. B. Furtado et al.   GENES & DEVELOPMENT

Comparative study of mouse and human feeder cells for human embryonic stem cells

(2008) Livia Eiselleova et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A Smad-binding Element in Intron 1 Participates in Activin-dependent Regulation of the Follistatin Gene

(2008) Amy L. Blount et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

(2007) Joseph R. Smith et al.   DEVELOPMENTAL BIOLOGY