Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner

Residue Lys57 in the Collagen-Like Region of Human L-Ficolin and Its Counterpart Lys47 in H-Ficolin Play a Key Role in the Interaction with the Mannan-Binding Lectin-Associated Serine Proteases and the Collectin Receptor Calreticulin

(2014) M. Lacroix et al.   JOURNAL OF IMMUNOLOGY

Identification of anti-retinal antibodies in patients with age-related macular degeneration

(2012) Kei Morohoshi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Studies of the Pattern Recognition Molecule H-ficolin

(2012) Rikke M. Zacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

(2012) Imran Bhutto et al.   MOLECULAR ASPECTS OF MEDICINE

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

(2011) I. A. Bhutto et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Lysosomal stress and lipid peroxidation products induce VEGF-121 and VEGF-165 expression in ARPE-19 cells

(2011) Marion Bergmann et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Sublytic Membrane-Attack-Complex (MAC) Activation Alters Regulated Rather than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers

(2011) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Natural Antibodies Propagate Cerebral Injury Following Ischemic Stroke in Mice

(2011) A. Elvington et al.   JOURNAL OF IMMUNOLOGY

Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway

(2011) Koichiro Tateishi et al.   MICROBIOLOGY AND IMMUNOLOGY

Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement

(2011) Nirmal K. Banda et al.   MOLECULAR IMMUNOLOGY

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization

(2011) Bärbel Rohrer et al.   MOLECULAR IMMUNOLOGY

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

(2011) David Weismann et al.   NATURE

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

(2011) L. V. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

(2011) W. J. Schwaeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction

(2010) M. S. Haas et al.   CARDIOVASCULAR RESEARCH

The significance of the complement system for the pathogenesis of age-related macular degeneration — current evidence and translation into clinical application

(2010) Peter Charbel Issa et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

PATHWAY-BASED THERAPIES FOR AGE-RELATED MACULAR DEGENERATION

(2010) Marco A Zarbin et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

REVIEW PAPER: Animals as Models of Age-Related Macular Degeneration

(2010) C. J. Zeiss   VETERINARY PATHOLOGY

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

(2009) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

New insights on the structural/functional properties of recombinant human mannan-binding lectin and its variants

(2009) Rema Rajagopalan et al.   IMMUNOLOGY LETTERS

Autoimmunity in retinal degeneration: Autoimmune retinopathy and age-related macular degeneration

(2009) Kei Morohoshi et al.   JOURNAL OF AUTOIMMUNITY

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

(2009) Joshua M. Thurman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorphisms in Mannan-Binding Lectin (MBL)-Associated Serine Protease 2 Affect Stability, Binding to MBL, and Enzymatic Activity

(2009) S. Thiel et al.   JOURNAL OF IMMUNOLOGY

C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells

(2009) D. A. Fraser et al.   JOURNAL OF IMMUNOLOGY

Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury

(2009) L. Kulik et al.   JOURNAL OF IMMUNOLOGY

Changes in Retinal Pigment Epithelium Related to Cigarette Smoke: Possible Relevance to Smoking as a Risk Factor for Age-Related Macular Degeneration

(2009) Ai Ling Wang et al.   PLoS One

Are low inflammatory reactions involved in exudative age-related macular degeneration?

(2008) A. Lommatzsch et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE