Review
Medicine, Research & Experimental
Xiao Li, Xinyuan Sun, Xuemin Guo, Xueren Li, Shouchun Peng, Xin Mu
Summary: Nucleic acid-mediated interferon signaling plays a pivotal role in defense against microorganisms, especially during viral infection. This article discusses the receptors involved in sensing nucleic acid molecules, their structures and functions, and the importance of their proper functioning in cell homeostasis and response to pathogen invasion. It also explores the impact of manipulating these receptors on defense mechanisms and presents the discovery of chemicals that can modulate their signaling activities.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Letter
Immunology
Josimar Dornelas Moreira, Fernanda Freire Campos Nunes, Fernanda Cristina Gontijo Evangelista, Henrique Rodrigues Silva, Marcela Iranda de Tonaco, Vicente de Paulo Coelho Peixoto de Toledo, Silvana Spindola de Miranda, Tania Mara Pinto Dabes Guimaraes
Summary: Patients with active pulmonary tuberculosis infection have elevated levels of circulating microparticles (MPs), which can modulate cytokine production of immune cells in vitro.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Critical Care Medicine
Sahil Gupta, James N. Tsoporis, Song-Hui Jia, Claudia C. dos Santos, Thomas G. Parker, John C. Marshall
Summary: This article discusses how host cells recognize danger signals using pattern recognition receptors, focusing on Toll-like receptors (TLRs) as the most studied class of PRRs. It reviews the expression, regulation, and function of different TLRs, emphasizing TLR-4, and how TLR adaptor protein binding directs intracellular signaling to activate or terminate an innate immune response. The recent progress in research on the involvement of S100 proteins as ligands for TLR-4 in inflammatory disease is also highlighted.
Article
Biochemistry & Molecular Biology
Maria Klatka, Agnieszka Polak, Paulina Mertowska, Sebastian Mertowski, Jakub Lyczba, Anna Hymos, Izabela Korona-Glowniak, Ewelina Grywalska
Summary: Chronic lymphocytic thyroiditis, or HD, is a common thyroid disorder. Research has focused on the role of Toll-like receptors (TLRs), particularly TLR2, in the pathogenesis of HD. This study found a significant increase in TLR2 expression on immune cells and a higher concentration of soluble TLR2 in plasma in HD patients compared to healthy individuals. TLR2 expression also correlated with thyroid function indicators. These findings suggest that TLR2 may be involved in the immunopathogenesis of HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Youying Zhang, Qilin Fan, Yuanlong Hou, Xuanshuang Zhang, Zhe Yin, Xiaoying Cai, Wei Wei, Jiaying Wang, Dandan He, Guangji Wang, Yonggui Yuan, Haiping Hao, Xiao Zheng
Summary: Disturbances in gut microbiome, particularly Bacteroides species, are implicated in major depressive disorder (MDD) susceptibility. This study demonstrates the differential impacts of Bacteroides fragilis, Bacteroides uniformis, Bacteroides caccae, and Bacteroides ovatus on depressive behavior and neurogenesis. The effects are partially mediated by alterations in tryptophan pathway metabolites and neurotransmitters along the gut-brain axis. Moreover, the intensified depletion of cerebral serotonin is associated with increased susceptibility to depression.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Endocrinology & Metabolism
Hai-Yun Guan, He-Xia Xia, Xiu-Ying Chen, Lu Wang, Zhi-Jing Tang, Wei Zhang
Summary: The activation of TLR4 was found to suppress CYP19A1 expression and E2 secretion in human granulosa cells via NF-κB signaling, which has implications for follicular development and estrogen synthesis regulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ling Wei, Xue-Sen Wen, Cory J. Xian
Summary: Chemotherapy-induced intestinal mucositis is a painful condition that affects a significant number of patients undergoing chemotherapy. Recent research has highlighted the relationship between dysbiosis of intestinal microbiota and mucositis, showing that chemotherapy can shape the microbiota and worsen mucositis through TLR signaling pathways. This review aims to explore how gut microbiota affects the pathogenesis of mucositis and provide potential new strategies for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rukmini Mukherjee, Anshu Bhattacharya, Denisa Bojkova, Ahmad Reza Mehdipour, Donghyuk Shin, Khadija Shahed Khan, Hayley Hei-Yin Cheung, Kam-Bo Wong, Wai-Lung Ng, Jindrich Cinatl, Paul P. Geurink, Gerbrand J. van der Heden van Noort, Krishnaraj Rajalingam, Sandra Ciesek, Gerhard Hummer, Ivan Dikic
Summary: Famotidine has no effect on viral replication but can modulate specific signaling pathways, reducing TLR3-dependent signaling processes and subsequent activation of IRF3 and the NF-kappa B pathway, leading to control of antiviral and inflammatory responses.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Immunology
Tianhao Duan, Yang Du, Changsheng Xing, Helen Y. Y. Wang, Rong-Fu Wang
Summary: This article provides a detailed overview of the innate immune system's defense mechanisms against pathogens, with a focus on the role of Toll-like receptors (TLRs) in immune responses. TLRs not only link innate immunity to adaptive immunity, but also directly regulate the function of T cells. In addition, the article discusses the critical role of TLR signaling in host defense against infectious diseases, autoimmune diseases, and cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Muhammad Saif-ur Rehman, Saif Ur Rehman, Wasim Yousaf, Faiz-ul Hassan, Waqas Ahmad, Qingyou Liu, Hongping Pan
Summary: Toll-like receptors (TLRs) are essential for regulating immune responses and disease resistance in chickens. By utilizing specific feed ingredients and yeast-derived products, the immunity and disease resistance of chickens can be enhanced, providing new avenues for healthy and profitable chicken production.
FRONTIERS IN GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Bingxin Li, Longsheng Hong, Yindan Luo, Bingqi Zhang, Ziyu Yu, Wanyan Li, Nan Cao, Yunmao Huang, Danning Xu, Yugu Li, Yunbo Tian
Summary: LPS is a virulence factor of Gram-negative bacteria and its excessive concentration in geese can induce liver damage and reduce production performance. In this study, transcriptome sequencing analysis identified 727 differentially expressed genes related to LPS-induced liver injury and enrichment analysis showed the involvement of Toll-like receptor, MAPK, NOD-like receptor, FoxO, and PPAR signaling pathways. The TLR7-mediated MAPK signaling pathway played a major role in LPS-induced liver injury in geese.
Article
Cell Biology
Linlin Ying, Hao Wu, Shuaishuai Zhou, Han Lu, Manyi Ding, Bo Wang, Shanshan Wang, Yanjun Mao, Fenglin Xiao, Yao Li
Summary: The experiment aimed to investigate the Toll-like receptor signaling pathway of quercetin regulating avian beta-defensin (AvBD) in the ileum of Arbor Acre (AA) broilers. The results showed that dietary supplementation with quercetin significantly decreased the mortality rate of broilers and had a positive impact on the intestinal microecological balance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Walter V. Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T. Grimaldo, Avantika Krishna, Michael J. Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina de la Garza, Marco Ramos-Castaneda, Scott E. Evans, Seyed Javad Moghaddam
Summary: By knocking out TLR2, 4, and 9 genes, we found that TLRs play an important role in the promotion of K-ras-driven lung adenocarcinoma by COPD-like airway inflammation caused by prolonged exposure to pathogenic foreign antigens in airway epithelial cells. Knockout of TLR2, 4, or 9 resulted in reduced tumor burden, angiogenesis, and tumor cell proliferation, accompanied by increased tumor cell apoptosis and reprogramming of the tumor microenvironment to an antitumorigenic state. Knocking out downstream signaling pathways, MyD88/NF-kappa B, in airway epithelial cells further confirmed these findings. Our study expands the understanding of TLR signaling in lung cancer and may contribute to the development of more reliable and effective prevention and treatment modalities for lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin, Xiao-Ming Yang
Summary: TLR5 activation plays a promoting role in the initial events of liver regeneration after partial hepatectomy. The TLR5 signaling positively regulates liver regeneration, suggesting the potential of TLR5 agonists to promote liver regeneration.
MILITARY MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chih-Ru Lin, Tong-You Wade Wei, Hsien-Yu Tsai, Ying-Ta Wu, Pei-Yu Wu, Shui-Tein Chen
Correction
Biochemistry & Molecular Biology
Chia-Che Tsai, Chih-Ru Lin, Hsien-Yu Tsai, Chia-Jung Chen, Wen-Tai Li, Hui-Ming Yu, Yi-Yu Ke, Wei-Ying Hsieh, Cheng-Yen Chang, Ying-Ta Wu, Shui-Tein Chen, Chi-Huey Wong
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemical Research Methods
Ming-Cheng Lin, Jiraporn Nawarak, Tai-Yuan Chen, Hsien-Yu Tsai, Jung-Feng Hsieh, Supachok Sinchaikul, Shui-Tein Chen
Article
Immunology
Hsien-Hua Liao, Yao-Chen Wang, Miles Chih-Ming Chen, Hsien-Yu Tsai, Johnson Lin, Shui-Tein Chen, Gregory Jiazer Tsay, Sun-Long Cheng
Article
Biochemical Research Methods
Kongsak Boonyapranai, Hsien-Yu Tsai, Miles Chih-Ming Chen, Supawadee Sriyam, Supachok Sinchaikul, Suree Phutrakul, Shui-Tien Chen
Article
Chemistry, Applied
Jung-Feng Hsieh, Chia-Jung Yu, Je-Yu Chang, Shui-Tein Chen, Hsien-Yu Tsai
FOOD HYDROCOLLOIDS
(2014)
Article
Agriculture, Multidisciplinary
Eric S. L. Hsiao, Jeff C. F. Chen, Hsien-Yu Tsai, Kay-Hooi Khoo, Shui-Tein Chen, Jason T. C. Tzen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2009)
Article
Chemistry, Multidisciplinary
Hsien-Hua Liao, Jiraporn Nawarak, Ken-lin Chang, Wei-Ying Hsieh, Hsien-Yu Tsai, Shui-Tein Chen, Sun-Long Cheng
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2011)
Article
Oncology
John Wen-Cheng Chang, Hui-Ping Liu, Meng-Heng Hsieh, Yueh-Fu Fang, Meng-Shu Hsieh, Jia-Juan Hsieh, Yu-Ting Chiu, Hsien-Yu Tsai, Yi-Hsuan Chen, Ya-Ting Chen, Hui-Yu Hsu, Ying-Tsong Chen, Shih-Feng Tsai, Yi-Rong Chen, Bae-Li Hsi, Shiu-Feng Huang
Article
Biochemistry & Molecular Biology
Shih-Fang Hsu, Yih-Gang Goan, Hsien-Yu Tsai, Yi-Ru Lin, Rue-Tsuan Liu, Jiin-Tsuey Cheng
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Biochemical Research Methods
Hsien-Yu Tsai, Kongsak Boonyapranai, Supawadee Sriyam, Chong-Jen Yu, Sz-Wei Wu, Kay-Hooi Khoo, Suree Phutrakul, Shui-Tein Chen
Article
Biochemical Research Methods
Kongsak Boonyapranai, Sakaewan Ounjaijean, Kanokwan Kulprachakarn, Laddawan Potpromance, Miles Chih-Ming Chen, Hsien-Yu Tsai, Shui Tien Chen
Summary: The study found that lung cancer patients have a higher frequency of the Hp1 allele, as well as significantly increased levels of serum Hp and fucosylation. There was a decreasing trend in fucosylation levels from Hp1-1 to Hp2-1, Hp2-2 in the patient group.
CURRENT PROTEOMICS
(2021)
Article
Oncology
SF Huang, HP Liu, LH Li, YC Ku, YN Fu, HY Tsai, YT Chen, YF Lin, WC Chang, HP Kuo, YC Wu, YR Chen, SF Tsai
CLINICAL CANCER RESEARCH
(2004)
Article
Pathology
HY Tsai, BL Hsi, IJ Hung, CP Yang, JN Lin, JC Chen, SF Tsai, SF Huang