Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

N-Glycosylation Determines Ionic Permeability and Desensitization of the TRPV1 Capsaicin Receptor

(2012) Nicholas A. Veldhuis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals

(2012) M. Sisignano et al.   JOURNAL OF NEUROSCIENCE

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Serine proteases mediate inflammatory pain in acute pancreatitis

(2011) Eugene P. Ceppa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells

(2011) Ravi K. Adapala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transient Receptor Potential Vanilloid 4 Activated Inflammatory Signals by Intestinal Epithelial Cells and Colitis in Mice

(2010) Emilie D'Aldebert et al.   GASTROENTEROLOGY

Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice

(2009) Fiore Cattaruzza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel

(2009) Hongquan Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Transient Receptor Potential Vanilloid Type 4–Deficient Mice Exhibit Impaired Endothelium-Dependent Relaxation Induced by Acetylcholine In Vitro and In Vivo

(2009) David X. Zhang et al.   HYPERTENSION

Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons

(2009) Y. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

(2008) Walter E. B. Sipe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats

(2008) Adrian Sculptoreanu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms

(2008) Nicolas Cenac et al.   GASTROENTEROLOGY

Tyrosine Phosphorylation Modulates the Activity of TRPV4 in Response to Defined Stimuli

(2008) Tomasz Wegierski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

(2008) Dong Ho Woo et al.   Molecular Pain

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

(2008) S. Materazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells

(2007) Mami Nagataki et al.   CELL BIOCHEMISTRY AND FUNCTION

Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells

(2007) Thomas Ducret et al.   CELL CALCIUM