期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 288, 期 12, 页码 8544-8559出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M112.411629
关键词
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资金
- FP-7Health-Prot Grant [229697]
- National Center for Research and Development
- National Science Center [OPUS 2011/03/B/NZ3/01970]
- European Union
- [ERA-NET-Neuron/03/2010]
The shape of the dendritic arbor is one of the criteria of neuron classification and reflects functional specialization of particular classes of neurons. The development of a proper dendritic branching pattern strongly relies on interactions between the extracellular environment and intracellular processes responsible for dendrite growth and stability. We previously showed that mammalian target of rapamycin (mTOR) kinase is crucial for this process. In this work, we performed a screen for modifiers of dendritic growth in hippocampal neurons, the expression of which is potentially regulated by mTOR. As a result, we identified Cyr61, an angiogenic factor with unknown neuronal function, as a novel regulator of dendritic growth, which controls dendritic growth in a beta 1-integrin-dependent manner.
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