Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases

Active Site Hydrophobic Residues Impact Hydrogen Tunneling Differently in a Thermophilic Alcohol Dehydrogenase at Optimal versus Nonoptimal Temperatures

(2012) Zachary D. Nagel et al.   BIOCHEMISTRY

Taking Ockham's razor to enzyme dynamics and catalysis

(2012) David R. Glowacki et al.   Nature Chemistry

Enzymatic Transition States, Transition-State Analogs, Dynamics, Thermodynamics, and Lifetimes

(2011) Vern L. Schramm   Annual Review of Biochemistry

Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein

(2011) Olayinka A. Oyeyemi et al.   BIOCHEMISTRY

A Twin-track Approach Has Optimized Proton and Hydride Transfer by Dynamically Coupled Tunneling during the Evolution of Protochlorophyllide Oxidoreductase

(2011) Derren J. Heyes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the Donor–Acceptor Distance and Dynamics on Hydride Tunneling in the Dihydrofolate Reductase Catalyzed Reaction

(2011) Vanja Stojković et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors

(2011) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity

(2011) Sonia Y. Lam et al.   PLOS BIOLOGY

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein stability and enzyme activity at extreme biological temperatures

(2010) Georges Feller   JOURNAL OF PHYSICS-CONDENSED MATTER

Temperature dependence of the flexibility of thermophilic and mesophilic flavoenzymes of the nitroreductase fold

(2010) Eric D. Merkley et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Effect of Dimerization on the Stability and Catalytic Activity of Dihydrofolate Reductase from the HyperthermophileThermotoga maritima

(2009) E. Joel Loveridge et al.   BIOCHEMISTRY

An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling

(2009) Judith P. Klinman   CHEMICAL PHYSICS LETTERS

Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction

(2009) Christopher R Pudney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A 21st century revisionist's view at a turning point in enzymology

(2009) Zachary D Nagel et al.   Nature Chemical Biology

Free-Energy Landscape of Enzyme Catalysis†

(2008) Stephen J. Benkovic et al.   BIOCHEMISTRY