Coherence between Cellular Responses andin VitroSplicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs

“Function-First” Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image-Based Screening

(2013) Christopher J. Schulze et al.   CHEMISTRY & BIOLOGY

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

(2013) D. S. Hong et al.   INVESTIGATIONAL NEW DRUGS

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

(2013) Xiangyang Liu et al.   JOURNAL OF ANTIBIOTICS

Stabilized Cyclopropane Analogs of the Splicing Inhibitor FD-895

(2013) Reymundo Villa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

(2013) Xiangyang Liu et al.   JOURNAL OF NATURAL PRODUCTS

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

Comparison of Splicing Factor 3b Inhibitors in Human Cells

(2012) Yang Gao et al.   CHEMBIOCHEM

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

p53 is activated in response to disruption of the pre-mRNA splicing machinery

(2012) N Allende-Vega et al.   ONCOGENE

Structure of FD-895 Revealed through Total Synthesis

(2012) Reymundo Villa et al.   ORGANIC LETTERS

Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor

(2012) Arun K. Ghosh et al.   ORGANIC LETTERS

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

(2011) Liying Fan et al.   ACS Chemical Biology

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

(2011) E. G. Folco et al.   GENES & DEVELOPMENT

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure

(2011) Sarah Müller et al.   ORGANIC LETTERS

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold

(2011) Mahesh Kumar Gundluru et al.   MedChemComm

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

(2010) Makoto Hasegawa et al.   ACS Chemical Biology

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF

(2010) Ryohei Furumai et al.   CANCER SCIENCE

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

(2010) Gabriel A. Roybal et al.   NUCLEIC ACIDS RESEARCH

A Stereoselective Synthesis of (+)-Herboxidiene/GEX1A

(2010) Arun K. Ghosh et al.   ORGANIC LETTERS

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity

(2009) Chandraiah Lagisetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

(2009) B. J. Albert et al.   MOLECULAR CANCER THERAPEUTICS

The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing

(2008) Kristine O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY