Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Reduction of β-Amyloid Accumulation by Reticulon 3 in Transgenic Mice

(2013) Wataru Araki et al.   Current Alzheimer Research

Diabetes-induced Central Neuritic Dystrophy and Cognitive Deficits Are Associated with the Formation of Oligomeric Reticulon-3 via Oxidative Stress

(2013) Bei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preventing Formation of Reticulon 3 Immunoreactive Dystrophic Neurites Improves Cognitive Function in Mice

(2013) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Role of APP and Aβ in Synaptic Physiology

(2012) Zilai Wang et al.   Current Alzheimer Research

Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

(2012) E. M. Rodrigues et al.   HUMAN MOLECULAR GENETICS

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

Retromers in Alzheimer’s Disease

(2012) Barbara M. Siegenthaler et al.   Neurodegenerative Diseases

VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1

(2012) C.-L. Wang et al.   Biology Open

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

(2012) M. Steuble et al.   Biology Open

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

(2012) Bastian Dislich et al.   Frontiers in Physiology

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

(2011) Robert Tamayev et al.   EMBO JOURNAL

Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

(2011) Guillaume Pidoux et al.   EMBO JOURNAL

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin

(2011) Gina M. Finan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

β-Site APP-cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

(2011) Jiangli Tan et al.   JOURNAL OF NEUROCHEMISTRY

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

(2011) Claudia Santosa et al.   NEUROBIOLOGY OF DISEASE

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RTN/Nogo in forming Alzheimer's neuritic plaques

(2010) Marguerite Prior et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

(2010) R. Tamayev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Amyloid Deposition in Mice Overexpressing RTN3 Is Adversely Affected by Preformed Dystrophic Neurites

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

The Cleavage Products of Amyloid-  Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites

(2009) V. Muresan et al.   JOURNAL OF NEUROSCIENCE

The Occurrence of Aging-Dependent Reticulon 3 Immunoreactive Dystrophic Neurites Decreases Cognitive Function

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

(2009) A. Szodorai et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of β-secretase BACE1

(2009) Hideaki Kume et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum

(2008) Yoko Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease

(2008) Harald Hampel et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION