Review
Chemistry, Medicinal
Kanwal Mahmood, Ashkan Emadi
Summary: Metabolic reprogramming contributes to tumor development and leads to metabolic vulnerabilities that can be targeted in cancer treatment. Alterations in fatty acid, folate, and amino acid metabolism pathways have been identified in hematological malignancies, providing new opportunities for developing novel cancer therapies targeting these pathways. Glutamine depletion and inhibition of the one-carbon metabolism are also being explored as potential therapeutic strategies for cancers dependent on these metabolic processes.
Article
Chemistry, Multidisciplinary
Robert J. Mayer, Joseph Moran
Summary: Only one alpha-keto acid is synthesized into an amino acid via reductive amination, while others are converted by transamination. The reactivity differences of keto acids in nonenzymatic reduction and reductive amination were quantified using BH3CN- as a model nucleophile, revealing pronounced differences among biological alpha-keto acids in the formation of amino acids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Elham Ahmed Kazerooni, Abdullah Mohammed Al-Sadi, Umer Rashid, II-Doo Kim, Sang-Mo Kang, In-Jung Lee
Summary: The study found that salvianolic acid treatment can improve agronomic traits of soybean and maize seedlings under drought stress and enhance their survival rate under osmotic stress conditions. Salvianolic acid treatment also helps maintain the physiological functions of plants, reduce the accumulation of harmful substances, and regulate the expression of key genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Microbiology
Quanju Xiang, Muhammad Arshad, Yakun Li, Huijuan Zhang, Yunfu Gu, Xiumei Yu, Ke Zhao, Menggen Ma, Lingzi Zhang, Maolan He, Qiang Chen
Summary: This study analyzed the transcriptome of mushrooms with different mycelial ripening times and found that fruiting body formation is mainly associated with amino acid metabolism. These findings provide a basis for the optimization of mushroom cultivation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinrui Huang, Xinxin Song, Xuan Wang, Huihui Zhou, Chengdong Liu, Kangsen Mai, Gen He
Summary: This study investigated the effects of different levels of lysine on digestion, absorption, and metabolism in turbot. The results showed that lysine restriction inhibited growth and feed utilization in fish, and affected the expression of digestive enzymes and amino acid transporters. Lysine deficiency also had an impact on blood lipid metabolism and hepatic intermediary metabolism.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Microbiology
Elham Ahmed Kazerooni, Sajeewa S. N. Maharachchikumbura, Abdullah Mohammed Al-Sadi, Umer Rashid, Sang-Mo Kang, In-Jung Lee
Summary: In this study, fungal strains isolated from the rhizosphere of healthy tomatoes were found to mitigate symptoms of drought and salinity stresses. These fungal strains exhibited plant growth promoting traits on solid media and positively impacted stressed tomato plants in a greenhouse experiment.
Article
Biochemistry & Molecular Biology
Jiao Wu, Sai-Ching Jim Yeung, Sicheng Liu, Aiham Qdaisat, Dewei Jiang, Wenli Liu, Zhuo Cheng, Wenjing Liu, Haixia Wang, Lu Li, Zhongmei Zhou, Rong Liu, Chuanyu Yang, Ceshi Chen, Runxiang Yang
Summary: Colorectal cancer patients who receive cysteine as part of parenteral nutrition have shorter overall survival, as cystine promotes cancer cell growth by inhibiting certain pathways and conferring resistance to chemotherapy. Manipulating cyst(e)ine content in nutritional formulations may improve colorectal cancer patient survival.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Plant Sciences
Mohammed S. Almuhayawi, Mohamed Abdel-Mawgoud, Soad K. Al Jaouni, Saad M. Almuhayawi, Mohammed H. Alruhaili, Samy Selim, Hamada Abd Elgawad
Summary: Sprouts from Chenopodium plants are enhanced in growth and nutritive value through inoculation of the endophytic bacterium Endo 2 (strain JSA11), leading to increased accumulation of bioactive metabolites such as antioxidants, vitamins, unsaturated fatty acids, and essential amino acids. The treatment also boosts antioxidant, antibacterial, and anti-inflammatory activities in the sprouts, demonstrating the potential of Endo 2 (strain JSA11) in enhancing the bioactive contents and biological properties of Chenopodium sprouts.
Article
Oncology
Xinbo Wang, Yueqing Chen, Xudong Wang, Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu'e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang, Ping Wang
Summary: This study uncovers a SOX2-SLC7A11 regulatory axis that confers resistance to ferroptosis in lung cancer stem-like cells.
Article
Multidisciplinary Sciences
Yoojeong Seo, Joyeon Kang, Tae Il Kim, Chan Gyu Joo
Summary: This study used MRI to investigate the correlation between glutamine uptake and the distribution of glutamine transporters, glutaminase, and CSC markers. The results showed a positive correlation between glutamine uptake and the distribution of ASCT2 and certain CSC markers.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dirk Mossmann, Christoph Mueller, Sujin Park, Brendan Ryback, Marco Colombi, Nathalie Ritter, Diana Weissenberger, Eva Dazert, Mairene Coto-Llerena, Sandro Nuciforo, Lauriane Blukacz, Caner Ercan, Veronica Jimenez, Salvatore Piscuoglio, Fatima Bosch, Luigi M. Terracciano, Uwe Sauer, Markus H. Heim, Michael N. Hall
Summary: Metabolic reprogramming is a hallmark of cancer, and arginine is identified as a second messenger-like molecule that promotes tumor growth by controlling the expression of metabolic genes.
Article
Agriculture, Dairy & Animal Science
Jiayu Wu, Yanan Wang, Yu An, Changyu Tian, Lingfeng Wang, Zuhong Liu, Desheng Qi
Summary: This study compared the gene expression differences in liver tissues of laying hens at different ages using RNA sequencing, and found that the transport and metabolism of amino acids changed during the growing period, which influenced the growth and development of the hens.
Review
Neurosciences
Hangzhen Li, Fancai Zeng, Cancan Huang, Qiqi Pu, Elizabeth Rosalind Thomas, Yan Chen, Xiang Li
Summary: This review aims to improve the life of Parkinson's disease patients by modifying energy metabolism. The main pathological features of Parkinson's disease are the loss of dopaminergic neurons and the formation of Lewy bodies. Mitochondrial damage, oxidative stress, inflammation, and abnormal protein aggregation are considered the main causes of Parkinson's disease. Abnormal energy metabolism is another cause of Parkinson's disease. Improving key molecules in glucose metabolism, lipid metabolism, and amino acid metabolism may benefit Parkinson's disease and aid in its diagnosis and treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Plant Sciences
Julien Besnard, Unnati Sonawala, Bal Maharjan, Eva Collakova, Scott A. Finlayson, Guillaume Pilot, John McDowell, Sakiko Okumoto
Summary: Amino acids play important roles in biosynthesis and signaling, affecting plant development and immune responses. Changes in amino acid levels can trigger stress phenotypes and pathogen resistance through various pathways, indicating a link between amino acid transport and stress responses.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Hao- Xiong, Hui-Tao Zhang, Hong-Wen Xiao, Chun-Lan Huang, Mei-Zhou Huang
Summary: The study found that metabolomic analysis can better differentiate different types and states of leukemia based on existing clinical diagnostic techniques. The metabolism of choline and betaine may be significantly related to the patient's blood lipid profile. The main enrichment pathways for distinguishing differential metabolites are amino acid metabolism and fatty acid metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)