Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart

Executive Summary: Heart Disease and Stroke Statistics—2012 Update

(2012) et al.   CIRCULATION

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome

(2012) Sean DeGrande et al.   HEART RHYTHM

Ankyrin-B Protein in Heart Failure

(2012) Farshid Kashef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of EHD3 in human and mammalian heart failure

(2012) Hjalti Gudmundsson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43

(2011) Xun Ai et al.   CARDIOVASCULAR RESEARCH

Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation

(2011) Shane R. Cunha et al.   CIRCULATION

Role of Protein Phosphatase 2A in Alzheimers Disease

(2011) P. Rudrabhatla et al.   Current Alzheimer Research

Ca2+-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling

(2011) Donald M. Bers   HEART RHYTHM

Oxidized CaMKII causes cardiac sinus node dysfunction in mice

(2011) Paari Dominic Swaminathan et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMKII in myocardial hypertrophy and heart failure

(2011) Mark E. Anderson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

(2011) Paul J. M. Wijnker et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

(2011) Andriy E. Belevych et al.   PLoS One

Targeting of Protein Phosphatases PP2A and PP2B to the C-Terminus of the L-Type Calcium Channel Cav1.2

(2010) Hui Xu et al.   BIOCHEMISTRY

EH Domain Proteins Regulate Cardiac Membrane Protein Targeting

(2010) Hjalti Gudmundsson et al.   CIRCULATION RESEARCH

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia

(2009) M. Marshall et al.   CARDIOVASCULAR RESEARCH

GSK-3β, a Therapeutic Target for Cardiomyocyte Protection

(2009) Tetsuji Miura et al.   CIRCULATION JOURNAL

miR-1 Overexpression Enhances Ca 2+ Release and Promotes Cardiac Arrhythmogenesis by Targeting PP2A Regulatory Subunit B56α and Causing CaMKII-Dependent Hyperphosphorylation of RyR2

(2009) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology

(2009) Persoulla Nicolaou   Frontiers in Bioscience-Landmark

A randomised, controlled study of rate versus rhythm control in patients with chronic atrial fibrillation and heart failure: (CAFE-II Study)

(2009) R J Shelton et al.   HEART

Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

(2009) Haiyun Ling et al.   JOURNAL OF CLINICAL INVESTIGATION

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium

(2009) Mark J. Kohr et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels

(2009) Shuiping Dai et al.   PHYSIOLOGICAL REVIEWS

Regulation of the ankyrin-B-based targeting pathway following myocardial infarction

(2008) Thomas J. Hund et al.   CARDIOVASCULAR RESEARCH

Obscurin Targets Ankyrin-B and Protein Phosphatase 2A to the Cardiac M-line

(2008) Shane R. Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

(2008) S. Le Scouarnec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES