Article
Biochemistry & Molecular Biology
Paola Cuomo, Chiara Medaglia, Ivana Allocca, Angela Michela Immacolata Montone, Fabrizia Guerra, Serena Cabaro, Ernesto Mollo, Daniela Eletto, Marina Papaianni, Rosanna Capparelli
Summary: The study demonstrates that Caulerpin, a bis-indole alkaloid isolated from algae, can serve as a molecular antagonist of FPRs, reducing immune response against Hp culture filtrate by reverting FPR2-related signaling cascade and counteracting inflammatory reactions triggered by Hp peptide Hp(2-20). The findings suggest Caulerpin as a promising therapeutic or adjuvant agent for attenuating inflammation caused by Hp infection and its adverse clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhao Zhang, Zhijie Zhu, Xincheng Liu, Zhenzhou Mi, Huiren Tao, Hongbin Fan
Summary: This study explores the significance of anoikis-related genes (ANRGs) in osteosarcoma and their impact on the immune landscape. It establishes a prognostic signature based on ANRGs and develops a model for predicting survival probability in osteosarcoma patients. The study also identifies chemotherapeutic agents suitable for different subtypes of osteosarcoma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biology
Edward S. Wickstead, Egle Solito, Simon McArthur
Summary: This review describes the similarities and differences between the two principal pro-inflammatory and anti-inflammatory FPR receptors, FPR1 and FPR2, and discusses their importance in the development of neuroinflammatory diseases and their potential as therapeutic targets.
Review
Biochemistry & Molecular Biology
Paola Cuomo, Marina Papaianni, Rosanna Capparelli, Chiara Medaglia
Summary: Formyl peptide receptors (FPRs) are cell surface receptors that play a key role in regulating inflammatory responses, with FPRL1 being the most versatile receptor recognizing various ligands and participating in Helicobacter pylori-induced gastric inflammation. Investigating the role of FPRs in H. pylori-associated chronic inflammation suggests them as potential targets for mitigating microbial and sterile inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Jiahui Zhu, Lingfei Li, Jiao Ding, Jinyu Huang, Anwen Shao, Bo Tang
Summary: Formyl peptide receptors (FPRs) are important biomarkers for neurological diseases as they regulate inflammatory responses and affect neurological disease progression. FPRs have dual inflammatory functional properties in the central nervous system, with FPR2 mediating the active resolution of inflammation and FPR1 being related to angiogenesis, cell proliferation, and neurogenesis. Treatment with FPRs-modulation may be effective for neurological diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Qiwen Liao, Richard D. Ye
Summary: G protein-coupled chemoattractant receptors, such as FPR2, play a crucial role in leukocyte chemotaxis and have diverse cellular functions in response to various agonists. Recent studies have provided insights into the structural and conformational aspects of FPR2, revealing its ability to bind different ligands in different poses.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sharon D'Souza, Archana Padmanabhan Nair, Ganesh Ram Sahu, Tanuja Vaidya, Rohit Shetty, Pooja Khamar, Ritika Mullick, Sneha Gupta, Mor M. Dickman, Rudy M. M. A. Nuijts, Rajiv R. Mohan, Arkasubhra Ghosh, Swaminathan Sethu
Summary: The study found significant changes in immune cell subsets and inflammatory factor profile on the ocular surface of keratoconus (KC) patients, indicating a distinct immuno-inflammatory component in KC pathogenesis. These alterations may be related to disease severity, allergy, eye rubbing, providing an additional therapeutic target for KC management.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Sophia Liu, J. Bryan Lorgulecu, Shuqian Li, Mehdi Borji, Irving A. Barrera-Lopez, Vignesh Shanmugam, Haoxiang Lyu, Julia W. Morriss, Zoe N. Garcia, Evan Murray, David A. Reardon, Charles H. Yoon, David A. Braun, Kenneth J. Livak, Catherine J. Wu, Fei Chen
Summary: This study developed a Slide-TCR-seq method to sequence the clonotypic T cell receptors (TCRs) in tissues with high resolution and identified the characteristic locations of T cells and their receptors. In human lymphoid germinal centers, spatially distinct TCR repertoires were found. The analysis of T cells in renal cell carcinoma and melanoma specimens revealed heterogeneous immune responses, with differences in T cell states and infiltration both intra- and inter-clonally, as well as distinct gene expression between tumor and immune cells. This method provides insights into the spatial relationships between clonality, neighboring cell types, and gene expression that drive T cell responses.
Article
Cell Biology
Zhixin Cyrillus Tan, Anja Lux, Markus Biburger, Prabha Varghese, Stephen Lees, Falk Nimmerjahn, Aaron S. Meyer
Summary: In this study, the binding of mixed Fc immune complexes to receptors was measured and found to match a mechanistic model, providing refined estimates of the affinities of Fc variants. Additionally, the model was shown to predict effector cell-elicited platelet depletion in humanized mice. Overall, this work demonstrates a quantitative framework for modeling mixed IgG Fc-effector cell regulation.
Article
Biochemistry & Molecular Biology
Letizia Crocetti, Claudia Vergelli, Gabriella Guerrini, Maria Paola Giovannoni, Liliya N. Kirpotina, Andrei Khlebnikov, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Elena Lucarini, Igor A. Schepetkin, Mark T. Quinn
Summary: Research has shown the potential value of N-formyl peptide receptors for the treatment of rheumatoid arthritis, with demonstrated efficacy in animal models. Further studies on pyridinone derivatives, supported by molecular modeling and pharmacological tests in rat models, have shown promising biological results.
Article
Multidisciplinary Sciences
Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan, Sergey Nasarov, Hilal A. Lashuel
Summary: This study investigates the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, showing that they form via distinct mechanisms and exert their toxicity via different pathways. The findings provide insight into the complex processes of Htt inclusion formation and maturation, involving polyQ-dependent aggregation, sequestration of lipids and proteins related to HD pathways, accumulation of dysfunctional organelles, and impairment of protein quality control mechanisms. Nuclear and cytoplasmic Htt inclusions exhibit distinct compositions and properties, suggesting different mechanisms of aggregation and toxicity.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Mariantonella Colucci, Azzurra Stefanucci, Adriano Mollica, Anna Maria Aloisi, Francesco Maione, Stefano Pieretti
Summary: Formyl peptide receptor type 2 (FPR2/ALX) plays a crucial role in recognizing pathogen-associated molecular patterns and damage-associated molecular patterns. It is highly expressed in myeloid cells and various other cell types. Research suggests that FPR2/ALX may be involved in pain control in the spinal cord.
Article
Biochemistry & Molecular Biology
Hsiang-Ruei Liao, Chin-Hsuan Lin, Jih-Jung Chen, Fu-Chao Liu, Ching-Ping Tseng
Summary: Epsilon-viniferin inhibits the respiratory burst induced by fMLP in human neutrophils by antagonizing formyl peptide receptor 1 in a reversible and non-competitive manner.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Shristi Pawnikar, Yinglong Miao
Summary: Chemokine receptors, especially CXCR4, play crucial roles in immune system responses, development of cardiovascular and central nervous systems, as well as various diseases. This study investigates the peptide agonist binding mechanism in CXCR4 through molecular simulations and provides mechanistic insights into the activation of CXCR4 by different peptide agonists.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ohad Rechnitz, Inna Slutsky, Genela Morris, Dori Derdikman
Summary: This study investigated the cognitive impairments in the hippocampal subfields DG and CA3 in a familial Alzheimer's disease model, revealing deficits in pattern separation and completion. The findings suggest region-dependent impairments and highlight the importance of studying neural network deficits at a finer resolution of microcircuits in understanding AD progression.
Article
Multidisciplinary Sciences
Thomas Blum, Ana Moreno-Perez, Martina Pyrski, Bernd Bufe, Anela Arifovic, Petra Weissgerber, Marc Freichel, Frank Zufall, Trese Leinders-Zufall
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Anna Palle, Marta Montero, Silvia Fernandez, Patricia Tezanos, Juan A. de las Heras, Valerie Luskey, Lutz Birnbaumer, Frank Zufall, Pablo Chamero, Jose Luis Trejo
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Alexander Perniss, Shuya Liu, Brett Boonen, Maryam Keshavarz, Anna-Lena Ruppert, Thomas Timm, Uwe Pfeil, Aichurek Soultanova, Soumya Kusumakshi, Lucas Delventhal, Oeznur Aydin, Martina Pyrski, Klaus Deckmann, Torsten Hain, Nadine Schmidt, Christa Ewers, Andreas Guenther, Geunter Lochnit, Vladimir Chubanov, Thomas Gudermann, Johannes Oberwinkler, Jochen Klein, Katsuhiko Mikoshiba, Trese Leinders-Zufall, Stefan Offermanns, Burkhard Schuetz, Ulrich Boehm, Frank Zufall, Bernd Bufe, Wolfgang Kummer
Article
Neurosciences
Eugenia Eckstein, Martina Pyrski, Silvia Pinto, Marc Freichel, Rudi Vennekens, Frank Zufall
MOLECULAR AND CELLULAR NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Lukas Busch, Stefan Vieten, Susan Broedel, Kristina Endres, Bernd Bufe
Summary: Inflammation plays a central role in neurodegenerative diseases, and formyl peptide receptors (FPRs) are key players in this process. FPRs trigger various signaling pathways that regulate immune and nervous system responses to inflammation. The interaction between FPRs and neuropathological and neuroprotective ligands, as well as their role in cell signaling pathways, are the focus of research.
BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lukas Busch, Zukaa al Taleb, Yu-Liang Tsai, Vu Thu Thuy Nguyen, Qi Lu, Christopher V. Synatschke, Kristina Endres, Bernd Bufe
Summary: This study provides a comprehensive overview of the interactions between FPRs and different AP peptides, revealing that FPR1, FPR2, and FPR3 may contribute to neuroinflammation in Alzheimer's disease through interaction with various AP variants.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biology
Michael Garratt, Ilkim Erturk, Roxann Alonzo, Frank Zufall, Trese Leinders-Zufall, Scott D. Pletcher, Richard A. Miller
Summary: Previous research has suggested that young mice are particularly sensitive to endocrine or nutritional signals during the first few weeks of life. Olfactory cues can influence early development and lifespan in mice, with female mice showing a significant increase in lifespan when exposed to odors from adult females during early stages.
Article
Biochemical Research Methods
Trese Leinders-Zufall, Ursula Storch, Michael Mederos, Navin K. Ojha, Kohei Koike, Thomas Gudermann, Frank Zufall
Summary: This protocol describes the use of three photoswitchable diacylglycerol analogs for ultra-rapid activation and deactivation of TRPC channels, enabling all-optical stimulation and shutoff in mammalian tissue slices.
Meeting Abstract
Behavioral Sciences
Anne-Charlotte Trouillet, Matthieu Keller, Chantal Moussu, Jan Weiss, Trese Leinders-Zufall, Lutz Birnbaumer, Frank Zufall, Pablo Chamero
Meeting Abstract
Physiology
T. Blum, A. Moreno-Perez, M. Pyrski, B. Bufe, A. Arifovic, P. Weissgerber, M. Freichel, F. Zufall, T. Leinders-Zufall
Meeting Abstract
Behavioral Sciences
Alexander Perniss, Bernd Bufe, Gabriela Krasteva-Christ, Shuya Liu, Maryam Keshavarz, Aya Soultanova, Stefan Offermanns, Ignartz Wessler, Jochen Klein, Ulrich Boehm, Frank Zufall, Wolfgang Kummer
Meeting Abstract
Behavioral Sciences
Martina Pyrski, Mahbuba Tusty, Eugenia Eckstein, Livio Oboti, Diego J. Rodriguez-Gil, Charles A. Greer, Frank Zufall
Meeting Abstract
Behavioral Sciences
Ana Moreno-Perez, Thomas Blum, Bernd Bufe, Martina Pyrski, Anela Arifovic, Petra Weissgerber, Marc Freichel, Frank Zufall, Trese Leinders-Zufall
Meeting Abstract
Behavioral Sciences
Trese Leinders-Zufall, Ursula Storch, Katherin Bleymehl, Michael Mederos y Schnitzler, James A. Frank, David B. Kondrad, Dirk Trauner, Thomas Gudermann, Frank Zufall