Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

(2012) Haijun Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

(2012) Tamara Tsalkova et al.   PLoS One

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

(2009) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology

(2009) Mélanie Métrich et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

(2008) Mélanie Métrich et al.   CIRCULATION RESEARCH