Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease

(2011) Géraldine Poisnel et al.   NEUROBIOLOGY OF AGING

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Alzheimer's disease: Effects of β-amyloid on mitochondria

(2010) Laurent Tillement et al.   MITOCHONDRION

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional aerobic glycolysis in the human brain

(2010) S. Neil Vaishnavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species

(2009) Kyungsun Choi et al.   CURRENT NEUROVASCULAR RESEARCH

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY