Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

DNA building blocks: keeping control of manufacture

(2011) Anders Hofer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Abundant Non-canonical dUTP Found in Primary Human Macrophages Drives Its Frequent Incorporation by HIV-1 Reverse Transcriptase

(2011) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Strand Transfer Activity of a Multiple-Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant with a Dipeptide Fingers Domain Insertion

(2011) Laura A. Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Immunodeficiency Virus Type 1 Modified To Package Simian Immunodeficiency Virus Vpx Efficiently Infects Macrophages and Dendritic Cells

(2011) N. Sunseri et al.   JOURNAL OF VIROLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1–derived lentiviral vectors

(2011) Grégory Berger et al.   Nature Protocols

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon

(2011) Thomas Pertel et al.   Retrovirology

The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication

(2011) Sarah K. Van Cor-Hosmer et al.   VIROLOGY

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

(2010) Laurieann Casey et al.   CYTOKINE

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

(2010) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAM as a protein interaction domain involved in developmental regulation

(2010) Jörg Schultz et al.   PROTEIN SCIENCE

Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity

(2010) Sarah K. Van Cor-Hosmer et al.   VIROLOGY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells

(2008) C. Goujon et al.   JOURNAL OF VIROLOGY

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

(2008) Pauline Chugh et al.   Retrovirology