Article
Immunology
Tobias Rutishauser, Marco Lepore, Daniela Di Blasi, Jean-Pierre Dangy, Salim Abdulla, Said Jongo, Kamaka Ramadhani, Kim Lee Sim, Stephen L. Hoffman, Marcel Tanner, Claudia Daubenberger, Gennaro De Libero
JOURNAL OF IMMUNOLOGY
(2020)
Editorial Material
Immunology
Lucia Mori, Gennaro De Libero
Review
Immunology
Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo, Lucia Mori, Gennaro De Libero
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Emilie Layre
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gennaro De Libero, Andrew Chancellor, Lucia Mori
Summary: MR1 is an important molecule with unique structural and biological features, playing a crucial role in antigen presentation to T cells. Its distinctive features include ubiquitous expression, monomorphism, and regulation of surface expression by antigen binding. The presented antigens differ from those presented by other molecules and include small metabolites, drugs, and tumor-associated antigens.
MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Christina K. S. Muller, Julian Spagnuolo, Annette Audige, Andrew Chancellor, Doris Russenberger, Alexandra U. Scherrer, Matthias Hoffmann, Roger Kouyos, Manuel Battegay, Gennaro De Libero, Roberto F. Speck, K. Aebi-Popp, A. Anagnostopoulos, M. Battegay, E. Bernasconi, J. Boni, D. L. Braun, H. C. Bucher, A. Calmy, M. Cavassini, A. Ciuffi, G. Dollenmaier, M. Egger, L. Elzi, J. Fehr, J. Fellay, H. Furrer, C. A. Fux, H. F. Gunthard, D. Haerry, B. Hasse, H. H. Hirsch, M. Hoffmann, I. Hosli, M. Huber, C. R. Kahlert, L. Kaiser, O. Keiser, T. Klimkait, R. D. Kouyos, H. Kovari, B. Ledergerber, G. Martinetti, B. Martinez de Tejada, C. Marzolini, K. J. Metzner, N. Muller, D. Nicca, P. Paioni, G. Pantaleo, M. Perreau, A. Rauch, C. Rudin, A. U. Scherrer, P. Schmid, R. Speck, M. Stockle, P. Tarr, A. Trkola, P. Vernazza, G. Wandeler, R. Weber, S. Yerly
Summary: Studies have found subtle phenotypical differences in TCR V delta 1 and MAIT cells in HIV-infected individuals developing HL, suggesting potential functional impairment and lower efficiency in detecting and eliminating malignant cells. Further longitudinal CD4(+) T cell count analysis may help identify patients at higher risk for developing HL.
INFECTIOUS AGENTS AND CANCER
(2021)
Article
Multidisciplinary Sciences
Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Haussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati
Summary: The study demonstrates that engineered human T cells can effectively target leukemia cells expressing CD1c through a specific mLPA-TCR, delaying leukemia progression in mouse models. This approach has the potential to overcome MHC barriers between different donors and recipients, reducing the risk of graft-versus-host disease.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Marthe Jontvedt Jorgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jerome Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Summary: The study shows that COX-2 inhibitors may reduce excess inflammation in TB patients via the LOX pathway and modulate phosphorylation patterns in monocytes. Further investigation on the immunomodulatory effects of adjunctive COX-2 inhibitors in TB is needed before recommending it as a HDT strategy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Ricardo C. H. del Rosario, Jeremie Poschmann, Carey Lim, Catherine Y. Cheng, Pavanish Kumar, Catherine Riou, Seow Theng Ong, Sherif Gerges, Hajira Shreen Hajan, Dilip Kumar, Mardiana Marzuki, Xiaohua Lu, Andrea Lee, Giovani Claresta Wijaya, Nirmala Arul Rayan, Zhong Zhuang, Elsa Du Bruyn, Cynthia Bin Eng Chee, Bernett Lee, Josephine Lum, Francesca Zolezzi, Michael Poidinger, Olaf Rotzschke, Chiea Chuen Khor, Robert J. Wilkinson, Yee T. Wang, George K. Chandy, Gennaro De Libero, Amit Singhal, Shyam Prabhakar
Summary: A genome-wide histone acetylation profiling study was conducted on patients with tuberculosis, revealing changes in acetylation that modulate potassium channel expression and apoptosis response in host immune cells. The study demonstrated the ability to independently validate the findings in different patient cohorts and identified potential causal variants for immune phenotypes. This study provides proof-of-principle for understanding host response mechanisms to pathogens.
NATURE MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gennaro Prota, Ana Victoria Lechuga-Vieco, Gennaro De Libero
Summary: In the past decade, there has been successful utilization of anti-tumour immune responses to improve the outcomes of patients with different cancers. However, only a subset of patients respond positively to immunotherapy, highlighting the need for novel approaches to enhance immune cell functions and identify major targets of anti-tumour immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Chelsea M. Brown, Robin A. Corey, Axelle Grelard, Ya Gao, Yeol Kyo Choi, Emanuel Luna, Martine Gilleron, Nicolas Destainville, Jerome Nigou, Antoine Loquet, Elizabeth Fullam, Wonpil Im, Phillip J. Stansfeld, Matthieu Chavent
Summary: Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) and is responsible for millions of deaths each year. The current treatment for TB is lengthy and expensive, and missed doses contribute to drug resistance. Understanding the structure and function of the Mtb cell envelope, particularly the plasma membrane, is crucial for developing new anti-TB drugs and improving treatment outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Sergio Fabian Mosquera-Restrepo, Sophie Zuberogoitia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, Cesar Segura, Carlos Alberto Pelaez Jaramillo, Mauricio Rojas, Jerome Nigou
Summary: An estimated one-third of tuberculosis (TB) cases go undiagnosed or unreported. Developing non-sputum-based point-of-care biomarker-based diagnostics for TB is a major priority. In this study, patient exhaled breath condensate (EBC) samples were analyzed to detect pulmonary TB. The presence of specific lipids, lipoglycan, and proteins in EBCs efficiently differentiated TB patients from controls. EBC analysis has the potential to facilitate clinical diagnosis of TB and monitor treatment efficacy.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Andrew Chancellor, Alessandro Vacchini, Gennaro De Libero
Summary: The discovery of MR1 presenting microbial antigens to MAIT cells has been a significant advancement in understanding immune recognition. The recent identification of MR1-restricted T cells and their self-reactivity suggests that the microbial antigens characterized so far may only represent a small portion of the potential structures presented by MR1. This opens up new perspectives on the role of MR1-restricted antigen presentation in immunity and disease.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Biology
Mairene Coto-Llerena, Marco Lepore, Julian Spagnuolo, Daniela Di Blasi, Diego Calabrese, Aleksei Suslov, Glenn Bantug, Francois Ht Duong, Luigi M. Terracciano, Gennaro De Libero, Markus H. Heim
Summary: IFNλ plays a crucial role in innate pathogen defense in the lung and intestine, with IFNλ4 inhibiting spontaneous clearance of HCV and affecting T-cell responses. However, the mechanism by which IFNλ4 promotes CD8(+) T-cell responses and inhibits host immunity to HCV infections remains unclear.
LIFE SCIENCE ALLIANCE
(2021)