Article
Oncology
Melitah Motlhale, Mazvita Muchengeti, Debbie Bradshaw, Wenlong Carl Chen, Mwiza Gideon Singini, Chantal Babb de Villiers, Cathryn M. M. Lewis, Noemi Bender, Christopher G. G. Mathew, Robert Newton, Tim Waterboer, Elvira Singh, Freddy Sitas
Summary: This study investigates the relationship between Kaposi sarcoma-associated herpesvirus (KSHV) infection, HIV-1 infection, and antiretroviral therapy (ART) rollout in South Africa. The findings show that KSHV seropositivity is higher in males and individuals with HIV, and lower in individuals with higher levels of education. KSHV seroprevalence decreases over time, coinciding with ART rollout and improvements in educational standards and hygiene.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Virology
Blossom Damania, Dirk P. Dittmer
Summary: This review provides an overview of the diverse manifestations of Kaposi sarcoma (KS) under various circumstances. It discusses the historical background of KS and KS-associated herpesvirus (KSHV), highlights the clinical diversity of KS presentations, summarizes our understanding of the tumor's cell of origin, explores KSHV viral load as a potential biomarker for acute infections and KS-related complications, and discusses immune modulators that affect KSHV infection, persistence, and KS disease.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Tung-Ying Chen, Horng-Woei Yang, Dar-Shong Lin, Zo-Darr Huang, Lung Chang
Summary: This study detected the presence of HIV and KSHV in HIV+ KS samples and classic KS controls using ddPCR and ISH techniques. The results demonstrated that HIV can infect CD34 (+) tumor cells and coexist with KSHV in KS.
Article
Multidisciplinary Sciences
Soo Mi Lee, Kenneth M. Kaye, Frank J. Slack
Summary: The study identified miR-127-3p as a potential tumor suppressor in Kaposi's sarcoma, inhibiting KSHV-driven cellular transformation and proliferation by directly targeting the oncogene SKP2. This led to G(1) cell cycle arrest, activation of the RB protein tumor suppressor pathway, and down-regulation of key oncoprotein transcription factors crucial for KSHV tumorigenesis. Restoring miR-127-3p may serve as a viable therapeutic strategy for Kaposi's sarcoma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Sara R. R. Privatt, Owen Ngalamika, Jianshui Zhang, Qinsheng Li, Charles Wood, John T. T. West
Summary: Despite the widespread use of ART and decreased HIV incidence, Kaposi Sarcoma (KS) remains highly prevalent in certain regions. Currently, there are no preventative measures or curative therapies for KS. A study has identified potential biomarkers and therapeutic targets for KS based on transcriptomic profiles from KS lesions and validated the expression of certain glycoproteins in human KS lesions and KSHV-infected cell line-derived mouse xenografts.
Article
Immunology
Peter Julius, Guobin Kang, Stepfanie Siyumbwa, Jane Musumali, For Yue Tso, Owen Ngalamika, Trevor Kaile, Fred Maate, Phyllis Moonga, John T. West, Peter Angeletti, Charles Wood
Summary: This case report presents a rare occurrence of co-infection and co-localization of KSHV and EBV in KS arising from the conjunctiva. The possibility of interactions between these two viruses within the same lesion is indicated. Further study is needed to determine the prevalence of EBV co-infection in KS and its impact on KS development and progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Angela Nalwoga, Katherine R. Sabourin, Wendell Miley, Conner Jackson, Mahdi Maktabi, Nazzarena Labo, Joseph Mugisha, Denise Whitby, Rosemary Rochford, Robert Newton
Summary: Previously, it was found that asymptomatic Plasmodium falciparum (Pf) malaria infection is associated with increased Kaposi sarcoma-associated herpesvirus (KSHV) viral load and antibody levels. The current study further investigated the association between clinical malaria and KSHV seropositivity and antibody levels. The results showed a significant association between clinical malaria and increased KSHV seropositivity and antibody levels.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
A. Zer, O. Icht, L. Yosef, D. Avram, O. Jacobi, E. Fenig, N. Kurman, I Peretz, S. Shamai, O. Merimsky, E. Ben-Ami, R. Shapira Frommer, A. E. Schwarzbach, H. Bernstine, R. Weitzen, O. Vornicova, G. Bar-Sela, S. M. Stemmer, M. Lotem
Summary: This study evaluated the efficacy and safety of nivolumab in combination with ipilimumab in cKS patients. The combination therapy showed promising activity and low toxicity in cKS patients. This study provides a new treatment option for cKS patients.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Razia Moorad, Edwards Kasonkanji, Joe Gumulira, Yolanda Gondwe, Morgan Dewey, Yue Pan, Alice Peng, Linda J. J. Pluta, Evaristar Kudowa, Richard Nyasosela, Tamiwe Tomoka, Hannock Tweya, Tom Heller, Salem Gugsa, Sam Phiri, Dominic T. T. Moore, Blossom Damania, Matthew Painschab, Mina C. C. Hosseinipour, Dirk P. P. Dittmer
Summary: A prospective cohort study in Malawi enrolled 122 HIV-positive KS patients and treated them with standard care. The one-year overall survival was 61%, progression-free survival was 58%, and the 48-week complete response rate was 35%. The study found that KS lesions can be differentiated into two types with different molecular compositions, suggesting heterogeneous clinical response to treatment and the development of KS in PLWH with well-controlled HIV infection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Peter O. Oluoch, Catherine S. Forconi, Cliff I. Oduor, Dominic A. Ritacco, Hoseah M. Akala, Jeffrey A. Bailey, Jonathan J. Juliano, John M. Ong'echa, Christian Munz, Ann M. Moormann
Summary: The prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) and the occurrence of endemic Kaposi sarcoma (KS) are higher in regions with malaria in sub-Saharan Africa. A study examined KSHV serological profiles and viral loads in children with acute malaria and healthy children from high and low malaria regions. The results showed that KSHV seroprevalence was significantly associated with malaria endemicity, and acute malaria episodes disrupted KSHV latency in seropositive children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Ashish Kumar, Michelle Salemi, Resham Bhullar, Sara Guevara-Plunkett, Yuanzhi Lyu, Kang-Hsin Wang, Chie Izumiya, Mel Campbell, Ken-ichi Nakajima, Yoshihiro Izumiya
Summary: The study used proximity labeling to explore interactions between KSHV viral proteins and cellular proteins, revealing cellular proteins involved in innate immune regulation. The results suggest that selective splicing factors play a role in the regulation of innate immune responses during KSHV replication.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Katherine R. Sabourin, Ibrahim Daud, Sidney Ogolla, Nazzarena Labo, Wendell Miley, Molly Lamb, Robert Newton, Denise Whitby, Rosemary Rochford
Summary: The study found that children with malaria have an increased risk of KSHV seroconversion, especially in high malaria transmission areas. As the annualized rate of malaria in children increases, the risk of KSHV seropositivity also increases.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Maverick Salyards, Ank E. Nijhawan, Jacky Kuo, Sheena M. Knights, Susana Lazarte, Nazzarena Labo, Wendell Miley, Denise Whitby, Lu-Yu Hwang, Anna-William Kornberg, Kayo Fujimoto, Elizabeth Y. Chiao
Summary: Kaposi sarcoma (KS) continues to be a significant health issue in high-risk populations in the southern United States, with a prevalence of 36.7% and an incidence rate of 8.9 per 100 person-years. This study found that KS-associated herpesvirus (KSHV) infection was more common among Black individuals, people living with HIV, and those with a history of syphilis. Further research on KSHV risk may help address health disparities in KS diagnosis and outcomes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Megan E. Hansen, Ralph Mangusan, Kathryn Lurain, Thomas Odeny, Jomy George, Crystal Lu, Maura Manion, Anaida Widell, Irene Ekwede, Denise Whitby, James L. Gulley, Sameer S. Kadri, Jason M. Elinoff, Amisha Barochia, Parizad Torabi-Parizi, Thomas S. Uldrick, Robert Yarchoan, Ramya Ramaswami
Summary: This retrospective study examined the clinical data of HIV and KAD patients admitted to the ICU. The results showed that the majority of patients had well controlled HIV, and a proportion of patients were diagnosed with additional KADs upon admission. Critical illness did not prevent some patients from receiving KAD-directed therapy in the ICU.
Article
Immunology
Warren Phipps, Scott V. Adams, Peter Mooka, James Kafeero, Semei Sekitene, Dennis Mubiru, Janet Nankoma, Constance Namirembe, Lazarus Okoche, Elizabeth B. Namubiru, Shadiah Kayemba, Kelsey K. Baker, Mary W. Redman, Corey Casper, Jackson Orem, Edus H. Warren
Summary: This study aimed to understand the impact of HIV infection on Kaposi sarcoma (KS) patients and identify factors associated with survival and treatment response. Results showed low survival rates for both HIV-positive and HIV-negative KS patients, highlighting the need for new staging and therapeutic approaches.
Meeting Abstract
Biochemistry & Molecular Biology
Petra Baresova, Jana Musilova, Barbora Lubyova
Review
Virology
Petra Baresova, Paula M. Pitha, Barbora Lubyova
JOURNAL OF VIROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Petra Baresova, Jana Musilova, Paula M. Pitha, Barbora Lubyova
MOLECULAR AND CELLULAR BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Barbora Lubyova, Jan Hodek, Ales Zabransky, Hana Prouzova, Martin Hubalek, Ivan Hirsch, Jan Weber
Article
Chemistry, Physical
Ivo S. Vinklarek, Lukas Vel'as, Petra Riegerova, Kristian Skala, Ilya Mikhalyov, Natalia Gretskaya, Martin Hof, Radek Sachl
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2019)
Article
Multidisciplinary Sciences
Vaclav Janovec, Jan Hodek, Kamila Clarova, Tomas Hofman, Pavel Dostalik, Jiri Fronek, Jaroslav Chlupac, Laurence Chaperot, Sarah Durand, Thomas F. Baumert, Iva Pichova, Barbora Lubyova, Ivan Hirsch, Jan Weber
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Analytical
Radek Sachl, Sabina Cujova, Vandana Singh, Petra Riegerova, Peter Kapusta, Hans-Michael Mueller, Julia P. Steringer, Martin Hof, Walter Nickel
ANALYTICAL CHEMISTRY
(2020)
Article
Cell Biology
Hana Langerova, Barbora Lubyova, Ales Zabransky, Martin Hubalek, Kristyna Glendova, Ludovic Aillot, Jan Hodek, Dmytro Strunin, Vaclav Janovec, Ivan Hirsch, Jan Weber
Article
Neurosciences
Petra Riegerova, Jindrich Brejcha, Dagmar Bezdekova, Tomas Chum, Eva Masinova, Nikola Cermakova, Saak Ovsepian, Marek Cebecauer, Martin Stefl
Summary: The neuroblastoma cell line SH-SY5Y is commonly used as an experimental model for studying Alzheimer's disease. In this study, it was found that the expression and localization of amyloid-beta protein precursor (A beta PP) in SH-SY5Y cells can be dramatically altered by inducing full differentiation with retinoic acid and BDNF. Failure to fully differentiate SH-SY5Y cells can lead to mislocalization of A beta PP.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Meeting Abstract
Medicine, General & Internal
N. Naumova, R. Sachl, S. Cujova, P. Riegerova, M. Hof, J. P. Steringer, W. Nickel
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Virology
B. Lubyova, J. Weber