Article
Biochemistry & Molecular Biology
Weihua Tao, Guibo Zhang, Chengyuan Liu, Lide Jin, Xuehua Li, Shuaifeng Yang
Summary: In this study, it was found that low-dose LPS protected against early brain injury (EBI) after subarachnoid hemorrhage (SAH) by modulating microglial M1/M2 polarization. This was achieved through the IL-10/IL-10R1 signaling pathway. Mechanistically, FOXO1 acted as a transcriptional activator of IL-10, and USP19 mediated the deubiquitination of FOXO1 to activate the IL-10/IL-10R1 signaling pathway. The protective effect of low-dose LPS was shown to be dependent on the regulation of microglial polarization.
Article
Virology
Mingqian Xu, Liang Zhang, Jinfu Feng, Shuaibing Yang, Yixuan Wang, Yuyi Wang, Meiyang Chen, Li Zhou, Junjie Zhang, Qingsong Qin
Summary: EBV-associated gastric cancer is a subtype of gastric cancer characterized by the presence of EBV genome and limited viral gene expression in malignant epithelial cells. Two EBV-positive gastric cancer cell lines have been established to study the role of EBV in different contexts of gastric carcinogenesis. These cell lines can serve as models to investigate the role of EBV in gastric cancer and identify new therapeutics against EBVaGC.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Medicine, General & Internal
Yin Xu, Ayako Hiyoshi, Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Katja Fall, Scott Montgomery
Summary: The study suggests that having infectious mononucleosis in childhood and especially adolescence is a risk factor associated with a diagnosis of multiple sclerosis, independent of shared familial factors.
Review
Cell Biology
Arghavan Zebardast, Sadra S. Tehrani, Tayebeh Latifi, Farzin Sadeghi
Summary: EBV-encoded miRNAs play a crucial role in the pathogenesis of EBVaGC, participating in carcinogenesis and the progression of malignancies by regulating gene expression and other activities.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jakob Woerner, Yidi Huang, Stephan Hutter, Carmelo Gurnari, Jesus Maria Hernandez Sanchez, Janet Wang, Yimin Huang, Daniel Schnabel, Michael Aaby, Wanying Xu, Vedant Thorat, Dongxu Jiang, Babal K. Jha, Mehmet Koyuturk, Jaroslaw P. Maciejewski, Torsten Haferlach, Thomas LaFramboise
Summary: This study analyzed deep DNA sequence data from 1870 patients with myeloid malignancies and found evidence of dysbiosis in disease cases, as well as distinct microbial signatures among disease subtypes. It also highlighted the association between microbial content and host gene mutations and myeloblast cell percentages. The study provided evidence that Epstein-Barr virus status refines risk stratification in low-risk myelodysplastic syndrome patients and constructed machine-learning classifiers to discriminate among disease subtypes based solely on bacterial content.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Sonia Jangra, Aradhana Bharti, Wai-Yin Lui, Vidyanath Chaudhary, Michael George Botelho, Kit-San Yuen, Dong-Yan Jin
Summary: This study identified EBV tegument protein BGLF2 as a potent suppressor of host interferon signaling by targeting STAT proteins for degradation and inactivation. The genetic disruption of BGLF2 led to enhanced host interferon response, unveiling its critical role in EBV infection and replication.
JOURNAL OF VIROLOGY
(2021)
Article
Biology
Victor Omoboyede, Ochapa Ibrahim, Haruna Isiyaku Umar, Taye Bello, Ayodeji Adeola Adedeji, Aqsa Khalid, Emmanuel Sunday Fayojegbe, Adunola Blessing Ayomide, Prosper Obed Chukwuemeka
Summary: The study aimed to develop a multiepitope-based polyvalent vaccine against EBV-associated tumors using an immunoinformatics approach. Thirty viable B-cell and T-cell epitopes were selected and conjugated to form the vaccine construct, showing desirable properties based on in silico evaluation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Virology
Qiliang Lu, Wen Fu, Guangxiong Ouyang, Qiuran Xu, Dongsheng Huang
Summary: This case highlights the importance of considering EBV infection in young patients with spleen rupture without obvious cause to prevent misdiagnosis and missed diagnosis.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Meng-He Zhao, Wen Liu, Ping Li, Lei Liu, Xing Zhang, Bing Luo
Summary: The RPMS1 gene was sequenced in 391 EBV-positive samples from patients with hematological malignancies in northern China, and five major types (RPMS1-A, RPMS1-B, RPMS1-C, RPMS1-E, and RPMS1-F) were identified. RPMS1-A was the main type and RPMS1-F was associated with hematologic malignancies.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Chun-Xu Liao, Chang-Song Deng, Xia Liang, Jian-Chuan Yang, Zhi-Zhong Chen, Xiao-Ying Lin, Cai-Feng Lin, Shen Chen, Song-Song Wu
Summary: This study presents a case of advanced intrahepatic cholangiocarcinoma (ICC) treated with a combination of immunotherapy and radiotherapy, resulting in complete remission and prolonged progression-free survival. The findings suggest that the combination of PD-1 inhibitors with radiotherapy may serve as a promising therapeutic strategy for treating this specific cancer subtype.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Ozgur Appak, Muge H. Ozkaratas, Ayca A. Sayiner
Summary: This study compared the performance of four different assays for detecting EBV infection markers, with Vidas showing excellent performance for all EBV profiles and Immulite and Vidas being most accurate in detecting VCA IgM. Overall, the evaluated assays had comparable performance.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Linlin Zhang, Ran Wang, Zhengde Xie
Summary: Epstein-Barr virus (EBV) is closely associated with several malignant and lymphoproliferative diseases. Aberrant methylation of viral DNA and the host genome plays a crucial role in EBV-associated diseases. EBV controls gene methylation by hijacking host epigenetic machinery, and its proteins interact with host epigenetic regulatory factors to mediate the methylation of important tumour suppressor gene promoters. Epigenetic modifications, particularly DNA methylation, can be targeted for epigenetic therapy against EBV-associated tumours. The methylation patterns in the host and EBV genomes may also have diagnostic and prognostic value.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Atsushi Kondo, Aya Shinozaki-Ushiku, Hirofumi Rokutan, Akiko Kunita, Masako Ikemura, Hiroharu Yamashita, Yasuyuki Seto, Genta Nagae, Kenji Tatsuno, Hiroyuki Aburatani, Daizo Koinuma, Tetsuo Ushiku
Summary: In this study, we report eight cases of EBV-associated gastric carcinoma (EBVaGC) with heterogenous EBER expression. Through detailed histological assessment and genetic/epigenetic analysis, we identified collision tumors of different origins in two patients and shared alterations between EBER-positive and -negative components in the other six patients. This study provides important insights into the histological features and genetic/epigenetic alterations in EBVaGC and the clinical significance of losing EBV in tumor progression and immune evasion.
JOURNAL OF PATHOLOGY
(2023)