Review
Cell Biology
Pengfei Lu, Yunzhe Lu
Summary: Epithelium is traditionally considered an immotile tissue, but recent research has shown that it is actually more motile than previously thought. Epithelial-mesenchymal transition (EMT) is a crucial process for embryonic development, organ formation, and cancer metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Phuong Thao Ly, Shaohai Xu, Melissa Wirawan, Dahai Luo, Xavier Roca
Summary: The study demonstrates that different isoforms of ZAP play overlapping yet different roles in antiviral defense and other cellular processes. The regulation of host mRNA by ZAP is mostly unknown, but splice-switching antisense oligonucleotides can modulate the balance between ZAP isoforms. The study also identifies new cellular transcripts and processes regulated by ZAP isoforms, such as unfolded protein response, epithelial-mesenchymal transition, and innate immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Biochemistry & Molecular Biology
Hadil Onallah, Sheethal Thomas Mannully, Ben Davidson, Reuven Reich
Summary: The study demonstrates the important role of PLD isoenzymes in regulating migration, invasion, metastasis, and EMT in HGSC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Simone Polvani, Sara Pepe, Sara Tempesti, Mirko Tarocchi, Giada Marroncini, Lapo Bencini, Elisabetta Ceni, Tommaso Mello, Lucia Picariello, Irene Simeone, Cecilia Grappone, Gabriele Dragoni, Lorenzo Antonuzzo, Elisa Giommoni, Stefano Milani, Andrea Galli
Summary: The expression of COUP-TFII_V2 in PDAC is associated with shorter overall survival and peripheral invasion, linked to epithelial to mesenchymal transition (EMT) and cancer progression. It may serve as a novel possible target for PDAC management.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Genetics & Heredity
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri
Summary: Lipid species have diverse biological functions based on structural differences, some of which interact with proteins as second messengers. The accumulation of phospholipid mediator PAF in the tumor microenvironment disrupts cellular homeostasis and increases metastatic potential.
FRONTIERS IN GENETICS
(2021)
Article
Physiology
Qi Chen, Chan Gao, Ming Wang, Xiao Fei, Ning Zhao
Summary: DKD is a leading cause of end-stage renal disease worldwide, with inflammation and fibrosis playing important roles in its pathogenesis. TRIM18 has been identified as a key player in DKD, with knockdown of TRIM18 inhibiting HG-induced EMT, inflammation, and fibrosis in kidney cells. The TRIM18/PTP1B/STAT3 signaling pathway could be a promising target for potential therapeutics in DKD treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Lingge Yang, Zhiqiang Wu, Wei Sun, Peng Luo, Shiqi Chen, Yong Chen, Wangjun Yan, Yan Li, Chunmeng Wang
Summary: The study revealed that CCNDBP1 is a tumor suppressor gene and potential prognostic marker in DDL, with low expression being associated with poor prognosis in patients. CCNDBP1 inhibits invasion and metastasis of DDL cells by repressing EMT and promoting cell apoptosis. Methylation of specific DNA sites can decrease CCNDBP1 expression and worsen patient prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yue Pu, Yao Wu, Yan Zhou, Li-hong Wan
Summary: Azithromycin (AZM) targets RACK1 to inhibit TGF-beta 1 mediated EMT in bronchial epithelial cells, leading to the suppression of cell migration and reversal of EMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lu, Shi-You Chen, Wei-Bing Xie
Summary: The study identified Nupr1 as a novel regulator promoting renal fibrosis, essential for fibroblast activation and/or epithelial-mesenchymal transition during renal fibrogenesis. Nupr1 mediated TGF-beta-induced myofibroblast activation and collagen synthesis by initiating Smad3 signaling pathway, and the Nupr1 inhibitor alleviated UUO-induced renal fibrosis.
Article
Dentistry, Oral Surgery & Medicine
Yuri Miyakawa, Risako Chiba-Ohkuma, Takeo Karakida, Ryuji Yamamoto, Saeko Kobayashi, Yasuo Yamakoshi, Yoshinobu Asada
Summary: This study investigated the differential response of TGF beta isoforms to epithelial-mesenchymal transition (EMT) in enamel epithelial cells. The results showed that EMT occurred in the presence of TGF-beta 1 and beta 3, but not TGF-beta 2. The Rho signaling pathway was identified as the main pathway associated with TGF-beta-induced EMT. The differences in response across TGF-beta isoforms were attributed to their endoglin-mediated binding affinity for the TGF-beta receptor.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Huai-Song Wang, Xingya Xia, Yingming Wang, Weiping Lyu, Mangmang Sang, Congcong Gu, Wenyuan Liu, Feng Zheng
Summary: This study developed an aptamer probe based on aggregation-induced emission (AIE) to monitor EMT biomarkers on cell membrane and evaluate the efficacy of anti-EMT drugs.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wan Hua, Sarantos Kostidis, Oleg Mayboroda, Martin Giera, Marten Hornsveld, Peter ten Dijke
Summary: TGF-beta induces metabolic reprogramming in epithelial cells during EMT, affecting glycolysis, TCA cycle, glutaminolysis, choline metabolism, cellular redox state, and other pathways. Inhibiting choline kinase alpha with a kinase inhibitor can attenuate TGF-beta-induced changes associated with EMT.
Article
Cell Biology
Yingying Chen, Zhong He, Bo Zhao, Rui Zheng
Summary: This study found that NPAS2 expression is significantly increased in the lung tissues of IPF patients and downregulated in human pulmonary type 2 epithelial cells. It was also discovered that NPAS2 is upregulated in a mouse model of lung fibrosis and silencing it can inhibit epithelial-mesenchymal transition (EMT) and alleviate pulmonary fibrosis. The study suggests that NPAS2 is a novel target gene of p53 in regulating EMT and pulmonary fibrosis in ATII cells.
CELLULAR SIGNALLING
(2023)