Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers

How Can HIV-Type-1-Env Immunogenicity Be Improved to Facilitate Antibody-Based Vaccine Development?

(2011) Per Johan Klasse et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice

(2011) Kaustuv Banerjee et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

(2011) M. Melchers et al.   JOURNAL OF VIROLOGY

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

(2011) A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

(2011) Ben-Jiang Ma et al.   PLoS Pathogens

Methods development for analysis of partially deglycosylated proteins and application to an HIV envelope protein vaccine candidate

(2010) Eden P. Go et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Simian Immunodeficiency Virus from the Sooty Mangabey and Rhesus Macaque Is Modified with O-Linked Carbohydrate

(2010) E. Stansell et al.   JOURNAL OF VIROLOGY

Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

(2010) J. M. Binley et al.   JOURNAL OF VIROLOGY

Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function

(2010) Dirk Eggink et al.   VIROLOGY

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

(2010) Laura M. Walker et al.   PLoS Pathogens

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins

(2009) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

(2009) Yun (Kenneth) Kang et al.   VACCINE

Biochemical and biophysical comparison of cleaved and uncleaved soluble, trimeric HIV-1 envelope glycoproteins

(2009) Antu K. Dey et al.   VIROLOGY

Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo

(2009) Kaustuv Banerjee et al.   VIROLOGY

Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopesʼ Accessibility

(2008) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion

(2008) Rogier W Sanders et al.   Retrovirology