Article
Immunology
Jie Lv, Mengyao Han, Guangyu Liu, Wei Zhuang, Chun Wang, Ling Xie, Kaidireya Saimaier, Sanxing Han, Changjie Shi, Qiuhong Hua, Ru Zhang, Changsheng Du
Summary: Apoptosis is important in maintaining the homeostasis of the body and immune system, but its dysfunction can lead to autoimmune diseases like multiple sclerosis (MS). An animal model, experimental autoimmune encephalomyelitis (EAE), is used to study MS. In this study, we found that carboplatin (CA), a platinum anti-tumor drug, reduced inflammation and demyelination in EAE mice. CA also decreased pathogenic T cell numbers and proportions in the spleen and lymph nodes of EAE mice. Additionally, CA induced apoptosis and inhibited T cell proliferation. These findings suggest that CA has potential as a novel drug for MS treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Goran Stegnjaic, Antonios D. Tsiailanis, Milica Lazarevic, Vasileios K. Gkalpinos, Neda Djedovic, Thomas Antoniou, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Dorde Miljkovic, Andreas G. Tzakos, Bojan Jevtic
Summary: Gallic acid, a phenolic acid found in various plants, nuts, and fruits, has anti-oxidative and anti-inflammatory properties. Its phenethyl ester, PEGA, reduces the release of inflammatory substances and ameliorates an animal model of central nervous system inflammatory disease.
Article
Immunology
Goran Stegnjaic, Milica Lazarevic, Dimitrios A. Diamantis, Neda Djedovic, Bojan Jevtic, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Andreas G. Tzakos, Dorde Miljkovic
Summary: This study evaluated the immunomodulatory properties of a phenethyl ester derivative of rosmarinic acid (PERA) in an animal model of central nervous system autoimmunity. PERA was found to have anti-encephalitogenic effects by shortening disease duration and reducing clinical scores, as well as inhibiting the production of encephalitogenic cytokines and nitric oxide. The study suggests that PERA could be a potential therapy for multiple sclerosis.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Summary: Multiple sclerosis (MS) is a disease that damages the brain and spinal cord, leading to paralysis. Recent research has shown that B cells play a significant role in the pathogenesis of MS, as autoantibodies from B cells are closely related to central nervous system damage and prognosis. Regulating the activity of antibody secreting cells may be linked to the severity of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tae Woo Kim, Yujin Kim, Wonsik Jung, Dong Eon Kim, Hyeongseop Keum, Youngju Son, Sangyong Jon
Summary: BRNPs have shown potential in delaying disease onset, suppressing disease progression and severity, and reducing disease incidence rate in the EAE mouse model, without the need for systemic immunosuppression. Studies have found that BRNPs negatively regulate the differentiation of naive CD4(+) T cells into Th17 cells by scavenging reactive oxygen species.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Katsunori Endo, Toko Sawa, Yuna Tanaka, Takeru Saiki, Hazuki Haga, Lana Rizeq, Haruka Aso, Momoka Isono, Fumie Niitsuma, Akihiro Masaki, Hidefumi Makabe, Sachi Tanaka
Summary: Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system caused by overactivation of T cells. Procyanidins, polyphenols with anti-inflammatory properties, can inhibit cytokine production in T cells. In this study, the effects of Procyanidin B2 gallate (PCB2DG) on T cell-mediated autoimmune disease were investigated. The results showed that oral administration of PCB2DG significantly improved symptoms in a model of MS. This improvement was associated with the suppression of T cell-mediated cytokines and the infiltration of T cells in the spinal cord, suggesting that PCB2DG ameliorated spinal cord injury. The glycolytic activity of spleen cells was also analyzed, revealing that PCB2DG inhibited the increase in glycolysis observed during the development of MS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miao He, Dong-Ming Wu, Yang-Yang Zhao, Ye Yu, Shi-Hua Deng, Teng Liu, Ting Zhang, Jing Li, Feng Wang, Ying Xu
Summary: In this study, the effects of the autophagy activator AZD8055 on EAE were evaluated, showing that AZD8055 significantly enhanced autophagy, reduced inflammation, and inhibited pyroptosis in the spinal cords of EAE model mice. By downregulating the ROS/NLRP3 pathway, AZD8055 ameliorated EAE through anti-inflammatory and anti-pyroptosis effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Pei-Xin Shen, Xing Li, Si-Ying Deng, Li Zhao, Yan-Yan Zhang, Xin Deng, Bing Han, Jie Yu, Yin Li, Zhe-Zhi Wang, Yuan Zhang
Summary: This study demonstrates the therapeutic effect of Urolithin A in an experimental autoimmune encephalomyelitis (EAE) animal model, with potential as a prospective therapeutic candidate for autoimmune diseases. The mechanism involves targeting the Aryl Hydrocarbon Receptor (AhR) and modulating signaling pathways to suppress inflammation and regulate immune cell functions at different stages of disease progression.
Article
Immunology
Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Chen
Summary: The study showed that Nox2 deficiency attenuates neural damage induced by EAE, reduces disease severity, pathogenic immune cells infiltration, demyelination, and oxidative stress in the CNS. It also revealed that microglial Nox2 plays a regulatory role in multiple pathways important for MS/EAE pathogenesis, suggesting that Nox2 inhibition may represent an important therapeutic target for MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Zou, Fang-jun Chen, Li-rong Deng, Qian Han, Chang-yin Huang, Shi-shi Shen, Brian Tomlinson, Yan-hong Li
Summary: Anemoside B4 (AB4) demonstrated significant preventive and therapeutic effects on experimental autoimmune encephalomyelitis (EAE) by modulating inflammatory responses and the gut microbiota, indicating its potential as a therapeutic agent for treating multiple sclerosis (MS).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Takashi Kobayashi
Summary: Multiple sclerosis is an autoimmune disease characterized by immune attack on the nerve myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, expressing chemokine receptor CCR6, is crucial in determining disease activity. The role of CCL20, the ligand of CCR6, in attracting immune cells to the central nervous system (CNS) in multiple sclerosis has not been fully understood. This study generated CCL20-knockout and CCR6-knockout mice using CRISPR/Cas9 system and found that the migratory function mediated by CCL20/CCR6 may not be necessary for the onset of experimental autoimmune encephalomyelitis (EAE).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Juan E. Tichauer, Gabriel Arellano, Eric Acuna, Luis F. Gonzalez, Nirmal R. Kannaiyan, Paola Murgas, Concepcion Panadero-Medianero, Jorge Ibanez-Vega, Paula I. Burgos, Eileah Loda, Stephen D. Miller, Moritz J. Rossner, Peter J. Gebicke-Haerter, Rodrigo Naves
Summary: Compelling evidence indicates that interferon (IFN)-gamma has both pathogenic and beneficial effects in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the mechanisms by which IFN-gamma promotes neuroprotection and its effects on central nervous system (CNS)-resident cells have remained unknown. This study investigated the impact of IFN-gamma on CNS infiltrating myeloid cells and microglia in EAE and revealed its therapeutic activity through the induction of homeostatic microglial subsets and regulation of gene expression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Alba Sanchez-Fernandez, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat, Ruben Lopez-Vales
Summary: This study reveals that there is an imbalance in the production of specialized pro-resolving mediators (SPMs) in patients with multiple sclerosis (MS) and in mice with experimental autoimmune encephalomyelitis (EAE), and increasing the bioavailability of SPMs, such as Maresin-1 (MaR1), can reduce inflammation and mediate therapeutic effects. These findings suggest that immunoresolvent therapies could be a novel approach for the treatment of MS.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Jing Wang, Fangyi Zhu, Wei Huang, Changxin Yang, Zhengyi Chen, Yanting Lei, Yanping Wang, Yanting Meng, Yumei Liu, Xijun Liu, Bo Sun, Hulun Li
Summary: Acupuncture at ST36 can alleviate autoimmune diseases by stimulating the sympathetic nerves of the spleen to promote anti-inflammatory differentiation of B and CD4+T cells. Activation of the ss2-AR-cAMP signaling pathway plays a significant role in this process, especially in B cells. Norepinephrine can enhance the anti-inflammatory differentiation of B and CD4+T cells in the presence of B cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ping Zhao, Xin Chen, Xudong Han, Yanping Wang, Yu Shi, Jiayu Ji, Yanting Lei, Ying Liu, Qingfei Kong, Lili Mu, Jinghua Wang, Wei Zhao, Guangyou Wang, Xijun Liu, Tongshuai Zhang, Yao Zhang, Bo Sun, Yumei Liu, Hulun Li
Summary: Electroacupuncture (EA) treatment can alleviate clinical symptoms of EAE, reduce spinal cord demyelination, regulate inflammatory cytokine levels, and modulate miR-155 and POMC expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
