Article
Medicine, Research & Experimental
Zafer Yonden, Farzaneh Bonyadi, Yavar Yousefi, Amin Daemi, Seyyedeh Touran Hosseini, Sana Moshari
Summary: This study reveals that chronic and high-dose nano-micelle curcumin (NMC) can suppress the redox capacity and stimulate mitophagy signaling in the testicles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Xiaofeng Zu, Lilan Luo, Zhen Wang, Jie Gong, Chao Yang, Yong Wang, Chunhui Xu, Xinhua Qiao, Xian Deng, Xianwei Song, Chang Chen, Bao-Cai Tan, Xiaofeng Cao
Summary: This study reveals that cold stress adversely affects rice growth and productivity. Defects in the pseudouridine synthase OsPUS1 lead to low-temperature albino seedlings and the accumulation of reactive oxygen species (ROS). The researchers identify a mitochondria-localized pentatricopeptide repeat protein SOP10 as a key factor in regulating mitochondrial superoxide and enhancing rice cold tolerance.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Yixiao Xu, Yongcai Zhao, Binghong Gao
Summary: TRPV1 channel plays a role in releasing Ca2+ from cells under high-temperature stress, thus enhancing mitochondrial biogenesis in skeletal muscle. High-temperature stress can benefit the adaptation of muscle mitochondria to aerobic capacity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Pang, Hao Zhang, Hui-wang Ai
Summary: In this study, an improved fluorescent indicator, TrxRFP2, was developed to track the redox state of Trx1 in the cytosol and nucleus. A new genetically encoded fluorescent indicator, MtrxRFP2, was also created to monitor the redox status of mitochondrial Trx. The subcellularly localized MtrxRFP2 was used for imaging mitochondrial redox changes in live cells.
Article
Environmental Sciences
Feibo Xu, Yanfei Li, Zheng Cao, Jian Zhang, Wanyue Huang
Summary: Aflatoxin B1 (AFB1) contaminates foodstuffs and feeds, causing liver injury and mitochondrial dysfunction, which triggers mitochondria-dependent apoptosis and ultimately induces hepatic lesions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Cell Biology
Chang Zhang, Xingyu Gao, Minghe Li, Xiao Yu, Fanke Huang, Yiming Wang, Yueqi Yan, Haiying Zhang, Yingai Shi, Xu He
Summary: The skin serves as the body's primary defense against environmental hazards and is susceptible to aging due to various internal and external factors. Mitochondria play a crucial role in maintaining skin health through processes such as mitochondrial dynamics, biogenesis, and mitophagy. This article reviews the factors causing skin aging, the impact of mitochondrial processes on aging, and the specific regulatory mechanisms involved.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Chengting Luo, Changmei Yang, Xueying Wang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: Research showed that nicotinamide supplementation can reduce fat mass in obese mice, improve glucose tolerance, and enhance mitochondrial function in adipose tissue. Nicotinamide activates NAMPT and increases cellular NAD(+) levels to reprogram cellular metabolism for better adipose tissue function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Laura C. A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J. Sansom, Hing Y. Leung, Imran Ahmad
Summary: The study demonstrates the association between PPARG and metastasis in prostate cancer, with PPARG over-expression leading to increased levels of AKT3, which in turn enhances PGC1α localization in the nucleus, driving mitochondrial biogenesis and providing higher energetic output for tumor cell progression towards metastasis through EMT.
Article
Biochemistry & Molecular Biology
Takujiro Homma, Sho Kobayashi, Hideyo Sato, Junichi Fujii
Summary: Mitochondrial superoxide plays a key role in ferroptosis induced by cysteine starvation, with suppression of complex III superoxide production effectively protecting cells from lipid peroxidation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Cell Biology
Stefan Geldon, Erika Fernandez-Vizarra, Kostas Tokatlidis
Summary: Mitochondria are double-membrane organelles that participate in cellular respiration through the oxidative phosphorylation system, with most proteins encoded in the nucleus and imported to different compartments. The intermembrane space of mitochondria contains diverse proteins crucial for the maturation and function of electron transport chain complexes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chenlu Wang, Hongxin Lin, Xiaoguang Ge, Jing Mu, Lichao Su, Xuan Zhang, Meng Niu, Huanghao Yang, Jibin Song
Summary: A NIR-IIb nanoprobe was developed for in vivo ratiometric imaging of GSH with high detection limit and linear relationship. The nanoprobe successfully detected and imaged GSH in both subcutaneous tumor and orthotopic colon tumor with high accuracy and resolution.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Endocrinology & Metabolism
Chunlu Yan, Yao Shi, Lingqing Yuan, Donghui Lv, Bai Sun, Jiayu Wang, Xiyan Liu, Fangyu An
Summary: Mitochondria play a crucial role in providing cellular energy and maintaining the balance between osteogenesis and osteoclast activity. Mitochondrial dysfunction disrupts this balance and contributes to the pathogenesis of osteoporosis. Targeted therapy of mitochondria in osteoporosis can provide novel strategies for prevention and treatment of this disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Edit Horvath, Krisztina Bela, Kitti Kulman, Nora Farago, Riyazuddin Riyazuddin, Agnes Galle, Laszlo G. Puskas, Jolan Csiszar
Summary: Salicylic acid (SA) plays a crucial role in defense against pathogens and abiotic stress responses. This study investigates the role of glutathione transferases (GSTs) in the transcriptional reprogramming of redox status-related genes. Our results show that different concentrations of SA have different effects on oxidative stress- and redox-related gene expression. The Atgst mutants exhibit lower vitality and different gene expression patterns compared to the wild type plants, indicating the involvement of AtGSTF8 and AtGSTU19 in redox signaling.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Neurosciences
Narasimha M. Beeraka, Marco F. Avila-Rodriguez, Gjumrakch Aliev
Summary: This article summarizes the role of mitochondrial DNA (mtDNA) variations and oxidative stress in the pathophysiology of schizophrenia (SZ). It highlights the perturbation of the NMDA neurotransmitter system and the interaction between mtDNA alterations in glial cells and redox dysregulation during oxidative stress in SZ treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luciane C. Alberici, Helena C. F. Oliveira
Summary: Changes in plasma triglyceride metabolism and dietary fatty acid types are major contributors to metabolic and cardiovascular diseases. Mitochondrial adaptive responses play a crucial role in increasing energy expenditure and reducing oxidative stress in facing metabolic challenges.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Delphine C. Douillet, Benoit Pinson, Johanna Ceschin, Hans C. Huerlimann, Christelle Saint-Marc, Damien Laporte, Stephane Claverol, Manfred Konrad, Marc Bonneu, Bertrand Daignan-Fornier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Genetics & Heredity
Roxane Marsac, Benoit Pinson, Christelle Saint-Marc, Maria Olmedo, Marta Artal-Sanz, Bertrand Daignan-Fornier, Jose-Eduardo Gomes
Article
Biology
Benoit Pinson, Johanna Ceschin, Christelle Saint-Marc, Bertrand Daignan-Fornier
Article
Multidisciplinary Sciences
Sandra Muller, Isabelle Ader, Justine Creff, Helene Lemenager, Pauline Achard, Louis Casteilla, Luc Sensebe, Audrey Carriere, Frederic Deschaseaux
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Sloetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije Koenders, Louis Casteille, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell & Tissue Engineering
Cedric Menard, Joelle Dulong, David Roulois, Benjamin Hebraud, Lea Verdiere, Celine Pangault, Vonick Sibut, Isabelle Bezier, Nadege Bescher, Celine Monvoisin, Melanie Gadelorge, Nicolas Bertheuil, Erwan Flecher, Louis Casteilla, Philippe Collas, Luc Sensebe, Philippe Bourinp, Nicolas Espagnolle, Karin Tarte
Article
Genetics & Heredity
Christelle Saint-Marc, Johanna Ceschin, Claire Almyre, Benoit Pinson, Bertrand Daignan-Fornier
Article
Multidisciplinary Sciences
Diego Velazquez, Marcel Albacar, Chunyi Zhang, Carlos Calafi, Maria Lopez-Malo, Javier Torres-Torronteras, Ramon Marti, Sergey I. Kovalchuk, Benoit Pinson, Ole N. Jensen, Bertrand Daignan-Fornier, Antonio Casamayor, Joaquin Arino
SCIENTIFIC REPORTS
(2020)
Article
Genetics & Heredity
Jean-Marc Blouin, Cecile Ged, Ganeko Bernardo-Seisdedos, Txomin Cabantous, Benoit Pinson, Antoine Poli, Herve Puy, Oscar Millet, Laurent Gouya, Fanny Morice-Picard, Emmanuel Richard
Summary: Congenital erythropoietic porphyria is a rare genetic disorder characterized by UROS deficiency, resulting in ineffective erythropoiesis and skin fragility. Therapeutic options are limited, but inducing iron depletion through phlebotomies may effectively reduce porphyrin accumulation and improve disease symptoms without causing anemia.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2021)
Article
Urology & Nephrology
Hannah Kaminski, Gabriel Marseres, Nathalie Yared, Marie-Julie Nokin, Vincent Pitard, Atika Zouine, Isabelle Garrigue, Severine Loizon, Myriam Capone, Xavier Gauthereau, Maria Mamani-Matsuda, Roxane Coueron, Raul V. Duran, Benoit Pinson, Isabelle Pellegrin, Rodolphe Thiebaut, Lionel Couzi, Pierre Merville, Julie Dechanet-Merville
Summary: mTOR inhibitors have been shown to enhance T cell function and reduce the incidence of CMV infection in kidney transplant recipients. This effect may be achieved by reducing the number of dysfunctional T cells.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Corinne Clave, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Lea Ibaelosa, Benoit Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov
Summary: Gasdermins are a family of proteins that control cell death reactions in both mammals and fungi. This study reveals the proteolytic regulation of Gasdermins in fungi, showing an evolutionary parallel between fungal and mammalian cell death pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Angele Tingaud-Sequeira, Elina Mercier, Vincent Michaud, Benoit Pinson, Ivet Gazova, Etienne Gontier, Fanny Decoeur, Lisa McKie, Ian J. Jackson, Benoit Arveiler, Sophie Javerzat
Summary: We have identified DCT encoding dopachrome tautomerase (DCT) as the eighth gene for oculocutaneous albinism. Loss of DCT function leads to eye hypopigmentation and retinal dystrophy. By investigating Dct mice, we found severe hypopigmentation in their retinal pigmented epithelium (RPE) from early stages, with specific cellular defects. Understanding the molecular regulation of retinal development and aging of the hypopigmented eye may help guide therapeutic strategies for patients with albinism.
Article
Food Science & Technology
Samuel Amintas, Pauline Beaumont, Charles Dupin, Isabelle Moranvillier, Isabelle Lamrissi, Elie Patel, Benjamin Fernandez, Alice Bibeyran, Julian Boutin, Tristan Richard, Stephanie Krisa, Francois Moreau-Gaudry, Aurelie Bedal, David Cappellen, Benoit Pinson, Veronique Vendrely, Sandrine Dabernat
Summary: This study investigated the differential impact of resveratrol on tumor cells and healthy cells by evaluating its metabolism and the expression of UGT1A genes. The findings revealed that resveratrol was more cytotoxic to tumor cells with downregulated UGTs, while overexpression of UGT1A10 gene reduced its cytotoxicity. Resveratrol also affected the cell cycle, nucleotide metabolism, and global transcription and translation in intestinal sensitive tumor cells. This study enhances our understanding of the antitumor action of resveratrol and provides insights for its selective treatment in colorectal tumors.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Florent Guerville, Marine Vialemaringe, Celine Cognet, Pierre Duffau, Estibaliz Lazaro, Charles Cazanave, Fabrice Bonnet, Olivier Leleux, Rodrigue Rossignol, Benoit Pinson, Camille Tumiotto, Frederic Gabriel, Victor Appay, Julie Dechanet-Merville, Linda Wittkop, Benjamin Faustin, Isabelle Pellegrin
Summary: The objective of this study was to determine the contribution of inflammasome activation in chronic low-grade systemic inflammation observed in patients with HIV on long-term suppressive antiretroviral therapy. Inflammasome activation was measured by cytokine analysis in patient serum and ex vivo stimulation of primary monocytes. The results showed higher levels of IL-18 in HIV-positive patients compared to HIV-negative controls, along with increased secretion of IL-1 beta in response to inflammasome stimulation. Oxidative stress was also observed in patient sera. In conclusion, HIV infection with long-term effective ART is associated with inflammasome activation and increased monocyte activation, possibly mediated by oxidative stress.
Article
Cell Biology
Maelle Duperray, Fanny Hardet, Elodie Henriet, Christelle Saint-Marc, Eric Boue-Grabot, Bertrand Daignan-Fornier, Karine Masse, Benoit Pinson
Summary: This study investigates the developmental requirements for purine metabolism using the Xenopus laevis model. The research shows that purine pathway genes are mainly expressed in nervous and muscular embryonic tissues and are essential for myogenesis. Knockdown of certain genes in the pathway results in defects in muscle formation.