Article
Multidisciplinary Sciences
Tae-Jun Song, Choon-Ho Park, Kyu-Ree In, Jong-Bae Kim, Joo Hee Kim, Miran Kim, Hye Jin Chang
Summary: Betulinic acid (BA) is a naturally occurring compound with various biological effects including anti-malarial, anti-inflammatory, anti-cancer, and recently discovered anti-obesity and anti-diabetic activities. BA activates AMPK, leading to reduced blood glucose levels, increased glucose uptake, and enhanced endurance in mice, indicating its therapeutic potential for diabetes.
Article
Biochemistry & Molecular Biology
Zarka Sarwar, Nusrat Nabi, Sameer Ahmed Bhat, Syed Qaaifah Gillani, Irfana Reshi, Misbah Un Nisa, Guillaume Adelmant, Jarrod A. Marto, Shaida Andrabi
Summary: In this study, we found that DBC1 interacts with PyST in mammalian cells, leading to the downregulation of DBC1 protein levels. Additionally, LKB1 can degrade DBC1 in an AMP kinase-independent manner and negatively regulates AKT1 activity through DBC1 and its downstream substrate TRB3. Furthermore, we demonstrated that DBC1 has oncogenic potential. Our findings provide insights into the LKB1-DBC1-AKT1 signaling paradigm and its role in cell cycle regulation, apoptosis, and tumorigenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fiona M. Russell, David Grahame Hardie
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy balance by promoting ATP production and inhibiting cell growth. It may restrain aberrant growth before tumorigenesis, but support the survival of cancer cells once cancer has arisen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Fang Qiannan, Joseph A. Bellanti, Zheng Song Guo
Summary: DBC1 is a human nuclear protein that plays a crucial role in modulating the activities of various proteins, with a focus on metabolism and epigenetics. It is known for its inhibition of SIRT1 and its significance in cancer and autoimmune diseases. Research has made new advances in understanding the structure, regulatory function, and importance of DBC1.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Veterinary Sciences
Xu-Yang Gao, Bu-Hao Deng, Xin-Rui Li, Yu Wang, Jian-Xin Zhang, Xiao-Yan Hao, Jun-Xing Zhao
Summary: The study found that melatonin enhances the formation of sheep brown adipocytes by activating AMPKα1, reducing lamb mortality and economic losses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Zhenjie Sun, Wenhui Gu, Zezhong Feng, Yaqin Fan, Jianfeng Niu, Guangce Wang
Summary: This study elucidated the expression regulation mechanism of the heat shock protein 70 gene in Neopyropia yezoensis under high temperature stress. The findings showed the involvement of cAMP-dependent protein kinase and activating transcription factors element in the transcription regulation of the gene. In addition, AMPK was also found to play a role in the induction of the gene. Furthermore, posttranscriptional mechanisms were proposed to be involved in the synthesis regulation of the heat shock protein 70-2 protein.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yiguang Lin, Huijun Ji, Xiaocong Cao, Yongjie Cen, Yumei Chen, Shuangshun Ji, Sichun Zheng
Summary: Insecticides are commonly used to control the serious pest Nilaparvata lugens in rice fields, but their repeated application can have negative effects. A study found that AMP-activated protein kinase (AMPK) plays a crucial role in maintaining energy metabolism and responding to insecticide treatment in N. lugens. Knockdown of NlAMPK alpha significantly enhanced the insecticidal efficiency of pymetrozine against N. lugens.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao
Summary: The study identified LKB1 as a direct activator of Sirt1 induced by resveratrol, showing that resveratrol promotes the binding between LKB1 and Sirt1. Furthermore, the LKB1-mediated phosphorylation of Sirt1 leads to increased mitochondrial biogenesis and respiration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Hui Quan, Mei Yin, Joungmin Kim, Eun-A Jang, Si-Ho Yang, Hong-Beom Bae, Seongtae Jeong
Summary: Resveratrol has beneficial effects on sepsis by regulating the inflammatory response, but its role in the development of endotoxin tolerance remains unclear. It has been found that resveratrol inhibits the expression of IRAK-M and SHIP1 through AMPK activation, suppressing the development of endotoxin tolerance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Liliana Felicia Iannucci, Anna Maria D'Erchia, Ernesto Picardi, Daniela Bettio, Filippo Conca, Nicoletta Concetta Surdo, Giulietta Di Benedetto, Deborah Musso, Cristina Arrigoni, Marco Lolicato, Mauro Vismara, Francesca Grisan, Leonardo Salviati, Luciano Milanesi, Graziano Pesole, Konstantinos Lefkimmiatis
Summary: The study reveals an unexpected mechanism by which EPAC1 enters the nucleus and regulates the transcription of a histone cluster by forming biomolecular condensates in its proximity in response to cAMP.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Tian Jin, Yong Zhang, Benson O. A. Botchway, Min Huang, Qicheng Lu, Xuehong Liu
Summary: This report examines the relationship between Sestrin2 and the AMPK/SIRT1 axis in ALS, a chronic neurodegenerative disease with poor prognosis. It reveals that Sestrin2 can improve metabolic, cardiovascular, and neurodegenerative diseases by activating the AMPK/SIRT1 signaling pathway. In addition, quercetin, a phytochemical, has various biological activities and can activate the AMPK/SIRT1 pathway to reduce endoplasmic reticulum stress, apoptosis, and inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Hwa Jin Kim, Sue Jin Moon, Jeong Hoon Kim
Summary: A recent study has found that CCAR2, also known as DBC1, acts as both a tumor suppressor and a tumor promoter. Initially considered a tumor suppressor due to its ability to stimulate apoptosis, CCAR2 has been found to also activate oncogenic transcription factors and regulate the enzymatic activity of epigenetic modifiers. Its dual role in cancer progression makes it a potential prognostic marker and understanding its mechanisms may lead to new treatments for various cancers.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
George Rasti, Maximilian Becker, Berta N. Vazquez, Maria Espinosa-Alcantud, Irene Fernandez-Duran, Andres Gamez-Garcia, Alessandro Ianni, Jessica Gonzalez, Laia Bosch-Presegue, Anna Marazuela-Duque, Anna Guitart-Solanes, Sandra Segura-Bayona, Joan-Josep Bech-Serra, Michael Scher, Lourdes Serrano, Uma Shankavaram, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg, Mireia Olivella, Travis H. Stracker, Carolina de la Torre, Alejandro Vaquero
Summary: SIRT1 plays a crucial role in regulating the DNA damage response by interacting with the PP4 phosphatase complex to control the signaling of DNA damage and repair.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shashank Saurav, Sunil Kumar Manna
Summary: This study uncovers the role of Profilin in autophagy induction and discovers the interaction between Profilin and AMPK, leading to autophagy induction and apoptosis.
Article
Hematology
Ying Wang, Ying Cao, Satsuki Yamada, Mahesh Thirunavukkarasu, Veronica Nin, Mandip Joshi, Muhammed T. Rishi, Santanu Bhattacharya, Juliana Camacho-Pereira, Anil K. Sharma, Khader Shameer, Jean-Pierre A. Kocher, Juan A. Sanchez, Enfeng Wang, Luke H. Hoeppner, Shamit K. Dutta, Edward B. Leof, Vijay Shah, Kevin P. Claffey, Eduardo N. Chini, Michael Simons, Andre Terzic, Nilanjana Maulik, Debabrata Mukhopadhyay
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2015)
Article
Oncology
Susmita Mondal, Debarshi Roy, Juliana Camacho-Pereira, Ashwani Khurana, Eduardo Chini, Lifeng Yang, Joelle Baddour, Katherine Stilles, Seth Padmabandu, Sam Leung, Steve Kalloger, Blake Gilks, Val Lowe, Thomas Dierks, Edward Hammond, Keith Dredge, Deepak Nagrath, Viji Shridhar
Article
Cell Biology
Juliana Camacho-Pereira, Mariana G. Tarrago, Claudia C. S. Chini, Veronica Nin, Carlos Escande, Gina M. Warner, Amrutesh S. Puranik, Renee A. Schoon, Joel M. Reid, Antonio Galina, Eduardo N. Chini
Article
Biochemistry & Molecular Biology
Eduarda Lopes Martins, Juliana Carvalho Ricardo, Eduardo de-Souza-Ferreira, Juliana Camacho-Pereira, Dionizio Ramos-Filho, Antonio Galina
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Leopoldo De Meis, Luisa A. Ketzer, Juliana Camacho-Pereira, Antonio Galina
BIOSCIENCE REPORTS
(2012)
Article
Oncology
Claudia C. S. Chini, Anatilde M. Gonzalez Guerrico, Veronica Nin, Juliana Camacho-Pereira, Carlos Escande, Maria Thereza Barbosa, Eduardo N. Chini
CLINICAL CANCER RESEARCH
(2014)
Article
Neurosciences
Alexandre Pastoris Muller, Clarissa Branco Haas, Juliana Camacho-Pereira, Andressa Wigner Brochier, Jussania Gnoatto, Eduardo Rigon Zimmer, Diogo Onofre de Souza, Antonio Galina, Luis Valmor Portela
EXPERIMENTAL NEUROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Douglas Jardim-Messeder, Juliana Camacho-Pereira, Antonio Galina
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2012)
Article
Neurosciences
Adriano Sebollela, Leo Freitas-Correa, Fabio F. Oliveira, Camila T. Mendes, Ana Paula Wasilewska-Sampaio, Juliana Camacho-Pereira, Antonio Galina, Helena Brentani, Fabio Passetti, Fernanda G. De Felice, Emmanuel Dias-Neto, Sergio T. Ferreira
NEUROTOXICITY RESEARCH
(2010)
Article
Plant Sciences
Juliana Camacho-Pereira, Laudiene Evangelista Meyer, Lilia Bender Machado, Marcus Fernandes Oliveira, Antonio Galina
Article
Multidisciplinary Sciences
Marcos A. Formiga-Jr, Juliana Camacho-Pereira
Summary: Mitochondrial dysfunction in peripheral nerves is associated with various diseases, and assessing mitochondrial function in mouse peripheral nerves can be challenging. This study presents a unique permeabilization protocol that allows for the evaluation of mitochondrial function in sciatic nerves, overcoming the limitations of small sample size, limited mitochondrial quantity, and presence of myelin sheath. By measuring reactive species production and comparing different mitochondrial substrates and inhibitors, this method enables the simultaneous detection of mitochondrial respiratory states, ROS, and mitochondrial complex activity.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Juliana Camacho-Pereira, Leonardo Osbourne Lai de Souza, Marina Santos Chichierchio, Camila Rodrigues-Chaves, Luiza de Sousa Lomba, Manoel Fonseca-Oliveira, Daniel Carvalho-Mendonca, Thaia Silva-Rodrigues, Antonio Galina
Summary: Aging is a time-related functional decline accompanied by mitochondrial dysfunction. CD38 plays a novel role in brain energy metabolism and aging by regulating hydrogen peroxide generation.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marcia Gracindo da Silva, Elisabete Mattos, Juliana Camacho-Pereira, Tatiana Domitrovic, Antonio Galina, Mauro W. Costa, Eleonora Kurtenbach
EXPERIMENTAL & CLINICAL CARDIOLOGY
(2012)