Article
Biotechnology & Applied Microbiology
Andrea L. Livieri, Facundo Colaccini, Martin A. Hernandez, Gabriela Gago, Hector M. Alvarez, Hugo Gramajo, Eduardo Rodriguez
Summary: In actinomycetes, acyl-CoA carboxylases (ACCs) are biotin-dependent enzymes with diverse structures and functions. Rhodococcus jostii RHA1 was found to have multiple putative ACC domains and subunits. Mutant strains with specific genes disrupted showed the importance of these genes in lipid biosynthesis and growth.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Buli Su, Peixuan Lai, Fan Yang, Anzhang Li, Ming-Rong Deng, Honghui Zhu
Summary: This study developed a novel method to increase the supply of acetyl-CoA in Saccharomyces cerevisiae and improve the production of downstream products. By optimizing metabolic pathways and conducting genetic engineering, the production of mevalonic acid was successfully increased, and further improvement was achieved by dynamically downregulating gene expression. The final strain produced a high yield of lycopene.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Amy Zheng, Seong Eun Kwak, Jesper B. Birk, Edward B. Arias, Dominic Thorley, Jorgen F. P. Wojtaszewski, Gregory D. Cartee
Summary: This study investigated the impact of caloric restriction (CR) on AMP-activated protein kinase (AMPK) and its substrates in skeletal muscle of older animals. The results revealed that CR significantly increased the phosphorylation of AMPK and several AMPK substrates, suggesting a potential role of AMPK in the antiaging effects of CR.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Microbiology
Pan Wang, Xin Wang, Ying Yin, Mingliang He, Wei Tan, Wenting Gao, Jianping Wen
Summary: The study found that inactivating the signal transduction protein GlnB can increase the production of ascomycin by enhancing the supply of precursors. Protein co-precipitation experiments and coupled enzyme activity assays revealed that the interaction between GlnB protein and the alpha subunit of acetyl-CoA carboxylase and propionyl-CoA carboxylase inhibited their activities.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Tonghui Huang, Xin Wu, Shirong Yan, Tianya Liu, Xiaoxing Yin
Summary: A series of spiroketopyrazole derivatives were synthesized and evaluated for their anticancer activities as ACC inhibitors. Compound 7j showed the strongest enzyme inhibitory activity, while compound 7m exhibited potent anti-proliferative effects against various cancer cell lines, indicating its potential as a therapeutic agent for hepatocellular carcinoma.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Microbiology
John E. Cronan
Summary: This review provides an update on the research of Escherichia coli acetyl-CoA carboxylase (ACC), focusing on the structures, stoichiometry, regulation of ACC activity and expression.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Ryo Mizojiri, Daisuke Tomita, Masako Sasaki, Yoshihiko Satoh, Yukiko Yamamoto, Hiroyuki Sumi, Hironobu Maezaki
Summary: By modifying the molecular length, a new ACC1-selective inhibitor 1i was discovered. Further chemical modification produced compound 1n with potent ACC1 selective inhibition and suitable PK profile for in vivo evaluations. This novel series of potent ACC1-selective inhibitors shows promise as both research tools and potential therapeutic agents.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Fei-Yuan Yu, Qian Xu, Qi-Yao Wei, Hai-Ying Mo, Qiu-Hua Zhong, Xiao-Yun Zhao, Andy T. Y. Lau, Yan-Ming Xu
Summary: ACC2 is under-expressed in cancerous tissue and negatively correlated with tumor size, lymph-node metastases, and clinical stage in lung adenocarcinoma. Knocking down ACC2 promotes cell proliferation and migration, and affects the expression of cell cycle-related genes. Lung adenocarcinoma patients with under-expressed ACC2 have a worse prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Microbiology
Tianyu Chen, Jing Yao, Keao Quan, Jingchen Xu, Xudong Hang, Qian Tong, Genyan Liu, Peipei Luo, Liping Zeng, Ganzhu Feng, Hongkai Bi
Summary: This study investigates the antifungal efficacy of firsocostat against Candida albicans. The combination of firsocostat with other antifungal agents shows synergistic effects in drug-sensitive and drug-resistant C. albicans strains. The study also demonstrates that firsocostat directly binds to C. albicans ACC and inhibits its enzymatic activity. These findings suggest that repurposing firsocostat holds promising potential in antifungal drug development and candidiasis treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Oncology
Yung-Chi Huang, Ming-Feng Hou, Ying-Ming Tsai, Yi-Chung Pan, Pei-Hsun Tsai, Yi-Shiuan Lin, Chao-Yuan Chang, Eing-Mei Tsai, Ya-Ling Hsu
Summary: This study revealed the role of metabolic reprogramming in the formation of an immunosuppressive pre-metastatic niche in breast cancer. The downregulation of ACACA gene led to senescence and inflammation of lung fibroblasts, which promoted the recruitment of immunosuppressive cells into the lungs.
Article
Biochemistry & Molecular Biology
Siraprapa Siritutsoontorn, Witchuda Sukjoi, Steven W. Polyak, Chareeporn Akekawatchai, Sarawut Jitrapakdee
Summary: HLCS plays a crucial role in breast cancer growth and migration by promoting the biotinylation of carboxylases. Depletion of biotin or reduced expression of HLCS inhibits cell proliferation and migration, leading to apoptosis in breast cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenyu Wu, Ruilin Chen, Yuanda Wan, Liren Li, Jiajia Han, Qiyun Lei, Zhipeng Chen, Shuwen Liu, Xingang Yao
Summary: Dengue fever is a common viral disease transmitted by mosquitoes, and there is a need for new drugs to combat it. Research suggests that inhibiting acetyl-CoA carboxylase (ACC) can effectively decrease the proliferation of the dengue virus and improve survival rates in infected mice.
Article
Biochemistry & Molecular Biology
Xin Wu, Yongbo Yu, Tonghui Huang
Summary: A potential ACC inhibitor was identified in this study, and a series of related compounds were synthesized for investigation, among which 6g showed the strongest ACC inhibitory activity, while 6l exhibited potent cytotoxicity. Preliminary mechanistic studies suggested that these compounds may act by reducing malonyl-CoA levels, arresting the cell cycle, and inducing apoptosis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biology
Sean Rogers, Hanaa Hariri, N. Ezgi Wood, Natalie Ortiz Speer, W. Mike Henne
Summary: This study reveals that yeast undergo metabolic remodeling at nucleus-vacuole junctions in response to acute glucose restriction, retaining HMGCRs and promoting mevalonate pathway flux in a spatially coordinated manner. The protein Nvj1 plays a crucial role in this process, demonstrating the importance of inter-organelle contacts in organizing metabolic reactions. Loss of HMGCR compartmentalization perturbs yeast growth following glucose starvation, indicating its role in adaptive metabolic remodeling.
Article
Food Science & Technology
Kaiyang Chen, Meimei Hu, Ming Tang, Congcong Gao, Haikuan Wang, Shuli Man, Fuping Lu
Summary: Appropriate intake of oligosaccharides can prevent obesity by regulating appetite, while butyrate consumption can alleviate obesity. The activity of acetyl-CoA carboxylase is inhibited by the conversion of butyrate to butyryl-CoA, which suggests possible obesity therapeutic targets.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Samad A. Ibitokou, Brian E. Dillon, Mala Sinha, Bartosz Szczesny, Anahi Delgadillo, Doaa Reda Abdelrahman, Csaba Szabo, Lutfi Abu-Elheiga, Craig Porter, Demidmaa Tuvdendorj, Robin Stephens
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemical Research Methods
Chandra Shekar R. Ambati, Furong Yuan, Lutfi A. Abu-Elheiga, Yiqing Zhang, Vivekananda Shetty
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2017)
Article
Cardiac & Cardiovascular Systems
M. Faadiel Essop, Heidi S. Camp, Cheol Soo Choi, Saumya Sharma, Ryan M. Fryer, Glenn A. Reinhart, Patrick H. Guthrie, Assia Bentebibel, Zeiwei Gu, Gerald I. Shulman, Heinrich Taegtmeyer, Salih J. Wakil, Lutfi Abu-Elheiga
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi
BIOCHEMICAL JOURNAL
(2012)
Article
Biochemistry & Molecular Biology
Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi
CHEMISTRY & BIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Lutfi Abu-Elheiga, Hongmei Wu, Ziwei Gu, Rubin Bressler, Salih J. Wakil
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Salih J. Wakil, Lutfi A. Abu-Elheiga
JOURNAL OF LIPID RESEARCH
(2009)
Article
Chemistry, Medicinal
Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi
JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Bingning Dong, Pradip K. Saha, Wendong Huang, Wenling Chen, Lutfi A. Abu-Elheiga, Salih J. Wakil, Robert D. Stevens, Olga Ilkayeva, Christopher B. Newgard, Lawrence Chan, David D. Moore
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Cheol Soo Choi, David B. Savage, Lutfi Abu-Elheiga, Zhen-Xiang Liu, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Richard M. Reznick, Roberto Codella, Dongyan Zhang, Gary W. Cline, Salih J. Wakil, Gerald I. Shulman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2007)
Article
Multidisciplinary Sciences
Jianqiang Mao, Francesco J. DeMayo, Huiguang Li, Lutfi Abu-Elheiga, Ziwei Gu, Tattym E. Shaikenov, Parichher Kordari, Subrahmanyam S. Chirala, William C. Heird, Salih J. Wakil
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Multidisciplinary Sciences
L Abu-Elheiga, MM Matzuk, P Kordari, W Oh, T Shaikenov, ZW Gu, SJ Wakil
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2005)
Article
Multidisciplinary Sciences
WK Oh, L Abu-Elheiga, P Kordari, ZW Gu, T Shaikenov, SS Chirala, SJ Wakil
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2005)
Article
Multidisciplinary Sciences
L Abu-Elheiga, WK Oh, P Kordari, SJ Wakil
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2003)
