Article
Chemistry, Multidisciplinary
Qi Feng, Xiaoyue Yu, Yixue Wang, Shiyang Li, Yang Yang
Summary: Breast cancer is the leading cause of cancer-related deaths among women globally, with HER2 overexpression significantly associated with higher breast tumor proliferation rates. A self-adjuvanting MFCH401-conjugated multiple-component anti-HER2 cancer vaccine was designed to induce a stronger and more durable immune response, showing enhanced immunogenicity compared to previous two-component conjugates.
Article
Virology
Yuexuan Wang, Honglin Han, Kecheng Zhu, Suifeng Xu, Chengzong Han, Yunxiang Jiang, Shina Wei, Qiwei Qin
Summary: In this study, Ec-Cathepsin D (Ec-CD) was identified from the orange-spotted grouper and its function in SGIV infection was investigated. The overexpression of Ec-CD inhibited SGIV replication, SGIV-induced apoptosis, and pro-inflammatory cytokine production. It also suppressed the activation of MAPK pathways.
Article
Food Science & Technology
Sara Kamali, Masoud Yavarmanesh, Mohammad B. Habibi Najafi, Arash Koocheki
Summary: This study examined the stabilization of Listeria phage A511 in whey protein concentrate (WPC), pullulan (PULL) films, and their composites. The results showed that the 30WPC:70PULL film had the best performance in terms of phage recovery and anti-Listerial properties.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Chemistry, Multidisciplinary
Mmed. Junfeng Sun, Mmed. Xiaojun Zheng, Mmed. Qiang Gao, Nisar Hussain Lone
Summary: This study investigated the effect of berberine on atherosclerosis-induced damage to the aorta wall in a mouse model. The results showed that berberine treatment significantly reversed the increase in lesion area caused by atherosclerosis. The treatment also reduced the expression of inflammatory markers and targeted the JAK/STAT pathway in atherosclerotic mice.
Article
Engineering, Environmental
Changxi Qi, Liping Li, Guodong Cheng, Bin Xiao, Yuxiao Xing, Xiaona Zhao, Jianzhu Liu
Summary: Platycodon grandiflorus polysaccharides (PGPS(t)) exhibit hepatoprotective effects in mice with acute liver injury induced by LPS/D-GalN, alleviating oxidative stress, reducing inflammatory cytokines, and enhancing the expression of anti-apoptotic proteins.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Immunology
Shan Qiao, Quan-ye Sun, Peng Zhou, Shan-chao Zhang, Zhi-hao Wang, Hai-yun Li, Ai-hua Wang, Xue-wu Liu, Tao Xin
Summary: This study investigates the role of NETs in anti-NMDAR encephalitis and finds that neutrophils from patients with this condition are more susceptible to NET generation. Additionally, elevated levels of various cytokines in the plasma of anti-NMDAR encephalitis patients were observed, and these levels were positively correlated with H3Cit levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yuchen Li, Keyu Yang, Fang Zhang, Jing Wang, Huijun Shen, Miaomiao Liu, Junhong Guo, Jie Wang
Summary: This study identified potential CSF biomarkers for the occurrence, development, and prognosis of anti-NMDAR encephalitis using high-throughput proteomic analysis. The identified biomarkers are associated with immune/inflammatory responses and altered levels of autophagy. These biomarkers show promise in evaluating the severity and prognosis of anti-NMDAR encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chetan Kumar, Gourav Chandan, Manoj Kushwaha, Amit Kumar, Sukhleen Kaur, Ajay Kumar, Govind Yadav, Sumeet Gairola, Ram A. Vishwakarma, Naresh Kumar Satti, Mahendra Kumar Verma
Summary: The present study isolated, identified, and quantified biomarker compounds in plant extracts of Habenaria intermedia D. Don. The compounds were isolated using column chromatography and characterized using NMR and mass spectral data. A new quantitative method using HPLC-PDA was established, resulting in the isolation and characterization of seven compounds. The study also revealed the immunomodulatory and anti-inflammasome activities of these compounds, suggesting their potential utilization as functional health supplements.
Article
Biochemical Research Methods
Ravindra Kulkarni, Krishna Kompalli, Naveen Gaddam, Chandrashekar Venkaraddi Mangannavar, Bikshupati Darna, Achaiah Garlapati, Dileep Kumar, Baswaraju Machha
Summary: The study reported the synthesis of novel pyrazolo[3,4-d]pyrimidines with significant anti-inflammatory and antitubercular activities. Some compounds exhibited potent activity against various bacterial and fungal strains. Molecular docking studies revealed favorable interactions in the active site of p38 kinase.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Materials Science, Multidisciplinary
Xiangping Hao, Jingzhi Yang, Lei Zhang, Chenhao Ren, Wen Li, Yuntian Lou, Hongchang Qian, Shougang Chen, Dawei Zhang
Summary: The study synthesized PDA/GO-Leu films with pH-responsive antibacterial and anti-adhesion properties, utilizing the release of D-leucine to achieve these effects. Analysis demonstrated the synergistic actions between D-leucine and GO in the films, which exhibited excellent biocompatibility.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Virology
Sunitha Kodidela, Namita Sinha, Asit Kumar, Santosh Kumar
Summary: Chemodietary agent Cur-D demonstrates antiviral effects against HIV in vitro and reduces HIV replication induced by cigarette smoke condensate. By lowering viral load and levels of pro-inflammatory cytokine IL-1 beta, Cur-D could be a promising adjunct therapy for treating HIV and reducing neurotoxicity of existing antiretroviral drugs.
Article
Nutrition & Dietetics
Yanfang Liu, Qingjiu Tang, Jie Feng, Jing Liu, Chuanhong Tang, Mengqiu Yan, Shuai Zhou, Liping Liu, Jing Zhou, Jingsong Zhang
Summary: The influence of molecular weight on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum was investigated. Lowering the molecular weight of beta-D-glucan improved its anti-inflammatory activity and significantly inhibited the expression of inflammatory cytokines. In a mouse model, the lower molecular weight fraction of beta-D-glucan was able to recover inflamed tissues and more effectively inhibit the secretion of pro-inflammatory cytokines.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Huihai Yang, Grace Gar-Lee Yue, Ping-Chung Leung, Chun-Kwok Wong, Ying-Jun Zhang, Clara Bik-San Lau
Summary: This study found that the natural gallotannin PGG has anti-tumor effects on colon cancer cells and inhibits cell proliferation, colony formation, motility, and migration. It also demonstrated that PGG suppresses liver and lung metastasis in mouse models and regulates immune cell populations and cytokine levels. These findings suggest that PGG has the potential to be developed as an anti-metastatic agent for metastatic CRC.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xing Fan, Jie Yin, Jiye Yin, Xiechuan Weng, Rigao Ding
Summary: The present study aimed to compare the clinical effects of vitamin E and vitamin D on a rat model of DSS-induced UC and to understand the underlying mechanisms associated with changes in cytokine levels. Administration of vitamin E orally promoted recovery of DSS-induced UC by inhibiting proinflammatory cytokines, with potential different mechanisms from vitamin D and glucocorticoid drugs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Hanyu Luo, Yuhang Li, Yaxin Zheng, Lvli Zhou, Jiaxin Yang, Zhixu Fang, Yan Jiang, Juan Wang, Zhengxiong Yao, Min Chen, Li Jiang
Summary: The NEOS score is a potentially reliable model to predict the one-year functional outcome in Chinese children with anti-NMDAR encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Neele Schumacher, Karsten Yan, Monja Gandrass, Miryam Mueller, Christoph Krisp, Robert Haesler, Antonella Carambia, Jerzy-Roch Nofer, Joanna P. Bernardes, Mouhamad Khouja, Ilka Thomsen, Karel Chalupsky, Julia Bolik, Christoph Hoelscher, Thomas Wunderlich, Johannes Herkel, Philip Rosenstiel, Christoph Schramm, Hartmut Schlueter, Thomas Renne, Hans-Willi Mittruecker, Stefan Rose-John, Dirk Schmidt-Arras
Summary: This study demonstrates that hepatocyte-specific gp130 activation is sufficient to trigger a robust systemic innate immune response in mice.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell Biology
Kristina Ritter, Jan Christian Sodenkamp, Alexandra Hoelscher, Jochen Behrends, Christoph Hoelscher
Summary: The study showed that the absence of IL-6 or gp130 on T cells has a minor effect on the development of antigen-specific TH1 and TH17 cells during experimental TB, and these gene-deficient mice were as capable as wild type mice in controlling mycobacterial infection.
Article
Multidisciplinary Sciences
Anne Kathrin Loesslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hoelscher, Christoph Hoelscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke
Summary: The study identifies monocyte progenitors with high giant cell-forming potential and the ability to accumulate cholesterol and lipids as key players in the immune response to mycobacteria. These monocyte progenitors may be exploited by mycobacteria to create a favorable niche for growth.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Hector Teran-Navarro, David Salcines-Cuevas, Ricardo Calderon-Gonzalez, Raquel Tobes, Jorge Calvo-Montes, Inmaculada Concepcion Perez-Del Molino Bernal, Sonsoles Yanez-Diaz, Manuel Fresno, Carmen Alvarez-Dominguez
Summary: It has been shown that using DC loaded with LM-GAPDH recombinant proteins as vaccine vectors is the safest and most immunogenic choice, providing effective protection against Listeria, Mycobacterium, and Streptococcus groups in adult vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
David Salcines-Cuevas, Hector Teran-Navarro, Ricardo Calderon-Gonzalez, Paula Torres-Rodriguez, Raquel Tobes, Manuel Fresno, Jorge Calvo-Montes, I. Concepcion Perez Del Molino-Bernal, Sonsoles Yanez-Diaz, Carmen Alvarez-Dominguez
Summary: The N-terminal 22 amino acid peptides of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are highly homologous among pathogenic bacteria like Listeria, Mycobacterium, and Streptococcus, making them ideal candidates for universal vaccine designs. Vaccines containing these peptides demonstrated high immunogenicity, lack of toxicity, and cross-protection immunity in mouse models infected with different pathogens.
Article
Infectious Diseases
Ignacio Barandalla, Carmen Alvarez, Pablo Barreiro, Carmen de Mendoza, Ruben Gonzalez-Crespo, Vicente Soriano
Summary: The study in Spain found that COVID-19 hospitalizations increased exponentially with age, with individuals over 60 years old accounting for 65% of all cases. The rapid vaccination rollout, especially prioritizing the elderly groups since the end of 2020, resulted in a sharp decline in COVID-19 hospitalizations starting in February 2021.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Kerstin Walter, Julia Kokesch-Himmelreich, Axel Treu, Franziska Waldow, Doris Hillemann, Nikolas Jakobs, Ann-Kathrin Lemm, Dominik Schwudke, Andreas Roempp, Christoph Hoelscher
Summary: This study evaluated the suitability of BALB/c IL-13(tg) mice as an animal model for determining the distribution of antibiotics within necrotizing lesions. MALDI-MS imaging analysis revealed drug-specific distribution within different lesion types. The study demonstrates that BALB/c IL-13(tg) mice recapitulate the penetration of antibiotics into human lesions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Vicente Soriano, Carmen Alvarez, Benson Edagwa, Carmen de Mendoza, Noemi Montoya, Ana Trevino, Howard Gendelman
Summary: Viral hepatitis is a significant global cause of mortality, with 1.4 million deaths each year. Hepatitis B and C account for 90% of these deaths, and the World Health Organization aims to eliminate viral hepatitis as a public health threat by 2030. While current antivirals can suppress viral replication, they cannot eliminate the virus from infected patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Kristina Ritter, Jasmin Rousseau, Christoph Hoelscher
Summary: This review discusses the importance of cytokine IL-27 in tuberculosis (TB) for protective inflammatory immune responses and the pathological sequelae of chronic inflammation. The timely restricted blockade of IL-27 signalling may promote better control of Mycobacterium tuberculosis (Mtb) infection but also lead to chronic hyperinflammation and immunopathology. IL-27 administration may be a potential treatment option for the immunopathological consequences of chronic TB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Julia Kokesch-Himmelreich, Axel Treu, Alan M. Race, Kerstin Walter, Christoph Hoelscher, Andreas Roempp
Summary: This article describes a mass spectrometry imaging workflow to evaluate drug penetration in tissue, specifically focusing on the distribution and penetration of anti-tuberculosis drugs in necrotic granulomas. The results demonstrate that clofazimine can penetrate to some extent into necrotic granulomas and accumulate in macrophages.
ANALYTICAL CHEMISTRY
(2022)
Letter
Immunology
Raquel Tobes, Eduardo Pareja
IMMUNOLOGY LETTERS
(2022)
Article
Oncology
Hector Teran-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Banos, Felix Campos-Juanatey, Sonsoles Yanez-Diaz, Almudena Garcia-Castano, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez
Summary: The study proposes a novel immunotherapy using gold nanoparticles bound to a bacterial toxin peptide as nanovaccines, showing promising results in pre-clinical experiments on bladder cancer. These nanovaccines activate the immune system, block tumor immunosuppression, and reduce tumor size. The potential of this immunotherapy can be extended to other solid tumors with lymphocyte infiltration.
Article
Chemistry, Medicinal
Julius Brandenburg, Jan Heyckendorf, Franziska Marwitz, Nicole Zehethofer, Lara Linnemann, Nicolas Gisch, Hande Karakoese, Maja Reimann, Katharina Kranzer, Barbara Kalsdorf, Patricia Sanchez-Carballo, Michael Weinkauf, Verena Scholz, Sven Malm, Susanne Homolka, Karoline Gaede, Christian Herzmann, Ulrich E. Schaible, Christoph Hoelscher, Norbert Reiling, Dominik Schwudke
Summary: Through lipidomic approaches, we have identified molecular markers for Mycobacterium tuberculosis complex (MTBC) infection that can be used to determine bacterial burden. Our targeted lipid assay is 30 times faster than conventional methods and can be completed within a day. We have also found elevated levels of these markers in the blood of tuberculosis patients, which decrease with successful treatment.
ACS INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Kristina Ritter, Jochen Behrends, Dominik Rueckerl, Alexandra Hoelscher, Johanna Volz, Immo Prinz, Christoph Hoelscher
Summary: IL-17A and IL-17F play a compensatory role in protecting against tuberculosis, and excessive neutrophil infiltration has detrimental effects on the response to Mtb infection.
