Article
Agriculture, Dairy & Animal Science
Jiying Liu, Ruilong Song, Shengyan Su, Nannan Qi, Qifa Li, Zhuang Xie, Shali Yu
Summary: Betaine can improve fat distribution and mitochondrial function in goose liver, with a certain repairing effect in a high-glucose culture medium, reducing fatty liver damage.
Article
Environmental Sciences
Yuezhu Zhang, Ju Hui, Yan Xu, Yingying Ma, Zhe Sun, Meng Zhang, Lushuang Nie, Lin Ye
Summary: This study revealed that MEHP exposure can inhibit the expression of STAT5A gene by causing oxidative damage, thereby accelerating the expression of key molecules in liver fibrosis. These findings contribute to the understanding of the role of MEHP in the development of liver diseases.
Article
Cell Biology
Yujuan Qi, Kai Zhang, Peijun Li, Zhenhua Wu
Summary: The study found that downregulating miR-217-5p could restore mitochondrial function of I/R-injured cardiomyocytes via targeting SIRT1, thus protecting cardiomyocytes against I/R-induced injury.
Article
Medicine, Research & Experimental
Zhihao Jiang, Huihui Wang, Ying Yang, Yao Yao, Haitian Ma
Summary: Excessive fat accumulation in broiler chickens threatens the poultry industry and consumers' health. Dietary supplements with bioactive ingredients, such as genistein, can effectively reduce fat deposition. This study found that genistein regulates lipid metabolism-related factors expression in chicken hepatocytes, leading to decreased lipid droplets accumulation.
Article
Biochemistry & Molecular Biology
Hui Li, Guilan Di, Yi Zhang, Junping Liang, Xianfeng Wang, Zhenshan Xu, Xianghui Kong
Summary: Cadmium exposure leads to inflammatory damage in the kidneys of fish, with miR-217 regulating the immunotoxicity of Cd in carp through its effect on SIRT1.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Cell Biology
Xin Wang, Bo Wang, Wei Gao, Yifei An, Guoying Dong, Jihui Jia, Qing Yang
Summary: H.Pylori infection induces autophagosome formation while inhibiting autophagic flux, with SIRT1 activation able to restore the inhibited autophagic flux caused by H. pylori infection. SIRT1 activation exerts inhibitory effects on intracellular survival and colonization of H. pylori. The relationship between H. pylori infection and SIRT1 expression was identified in clinical specimens, highlighting the therapeutic potential of SIRT1 as a target to eradicate H. pylori infection.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yi-Fa Lin, Jessica Sam, Todd Evans
Summary: The mitochondrial unfolded protein response (UPRmt) plays a crucial role in zebrafish fin regeneration by activating in injured fin tissue shortly after injury. The Sirt1UPR(mt) pathway, known for promoting lifespan extension, is essential for fin regeneration, with NAD(+) metabolism contributing to Sirt1 activity in this context. Activation of Sirt1 induces mitochondrial biogenesis in injured fin tissue, leading to UPRmt activation and promoting tissue regeneration.
Article
Food Science & Technology
Jaeeun Jung, Jeongjin Park, Minhee Lee, Jinhak Kim, Dongchan Oh, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: In this study, the potential anti-obesity effects of Salacia reticulata extracts (SC) were explored in obese mice and 3T3-L1 adipocytes, revealing that SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size. SC treatment also exerted inhibitory effects on adipogenesis and lipogenesis, while promoting lipolysis and thermogenesis pathways. These findings suggest that SC has a direct influence on lipid metabolism of adipocytes, making it a promising candidate for weight loss interventions.
Article
Toxicology
Jiabin Chen, Weina Lai, Yaotang Deng, Min Liu, Ming Dong, Zhidong Liu, Ting Wang, Xiang Li, Zhiqiang Zhao, Xiao Yin, Jinmei Yang, Rian Yu, Lili Liu
Summary: This study investigated the role of miR-363-3p in Cd-induced nephrotoxicity in occupational workers. The findings suggest that the increase of miR-363-3p is associated with down-regulation of PI3K and suppressed proliferation and enhanced apoptosis of renal tubule epithelial cells. MiR-363-3p may be considered for possible therapeutic strategies for Cd-associated kidney damage.
TOXICOLOGY LETTERS
(2021)
Article
Cell Biology
Zhibo Wang, Dianwei Shi, Nan Zhang, Tao Yuan, Huajie Tao
Summary: Studies have shown that miR-217 induces vascular endothelial cell senescence by targeting the SIRT1/p53 signaling pathway, providing a new basis for research in this area.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Zhiwang Zhang, Tingli Pan, Yu Sun, Siqi Liu, Ziyi Song, Haojie Zhang, Yixing Li, Lei Zhou
Summary: The study showed that calcium addition promotes intramuscular fat accumulation by inhibiting fatty acid oxidation, providing a new approach for increasing intramuscular fat content and improving meat quality.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Oncology
Shouhua Wang, Huanjun Tong, Tingting Su, Di Zhou, Weibin Shi, Zhaohui Tang, Zhiwei Quan
Summary: This study revealed that high expression of circTP63 in GBC is associated with poor prognosis, and knocking down circTP63 effectively inhibits proliferation and invasion of GBC cells, thereby suppressing tumor growth and progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jie Yan, Fan Yang, Dengyun Wang, Yuan Lu, Li Liu, Zhengjun Wang
Summary: Inflammation and oxidative stress play crucial roles in the initiation and progression of septic lung injury, and miR-217 is identified as a potential therapeutic target for this condition. Treatment with miR-217 antagomir alleviates inflammation and oxidative stress, while miR-217 agomir exacerbates these responses in vivo and in vitro. Further research shows that SIRT1 is responsible for the anti-inflammatory and anti-oxidant effects mediated by miR-217 antagomir.
FREE RADICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Youdong Li, Yong-Jiang Xu, Chin Ping Tan, Yuanfa Liu
Summary: This study found that sinapine can protect the liver by down-regulating the expression of MCJ protein to inhibit oxidative stress. The research also confirmed that sinapine can reduce MDA levels, increase SOD and GSH-Px levels, and decrease ROS levels and mitochondrial membrane potential, further supporting its protective effects on the liver.
Article
Pharmacology & Pharmacy
L-M Li, S. J. Hao, M. Ni, S. Jin, Y-Q Tian
Summary: DUXAP8 is highly upregulated in ovarian cancer tissues and cell lines, correlating with poor patient prognosis; Knockdown of DUXAP8 significantly inhibits proliferation and migration of OCa cells; DUXAP8 binds and negatively regulates the expression of microRNA-29a-3p in OCa, involving in the malignant progression of the tumor.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Zheng Shen, Xiaomei Liang, Christopher Q. Rogers, Drew Rideout, Min You
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Xiaomei Liang, Ming Hu, Christopher Q. Rogers, Zheng Shen, Min You
ANTIOXIDANTS & REDOX SIGNALING
(2011)
Article
Gastroenterology & Hepatology
Ming Hu, Fengming Wang, Xin Li, Christopher Q. Rogers, Xiaomei Liang, Brian N. Finck, Mayurranjan S. Mitra, Ray Zhang, Dave A. Mitchell, Min You
Article
Gastroenterology & Hepatology
Yanhua Peng, Drew A. Rideout, Steven S. Rakita, William R. Gower, Min You, Michel M. Murr
JOURNAL OF GASTROINTESTINAL SURGERY
(2010)
Article
Gastroenterology & Hepatology
Yanhua Peng, Drew Rideout, Steven Rakita, Mini Sajan, Robert Farese, Min You, Michel M. Murr
JOURNAL OF GASTROINTESTINAL SURGERY
(2009)
Article
Surgery
Drew A. Rideout, Yanhua Peng, Steven S. Rakita, Karan Desai, William R. Gower, Min You, Michel M. Murr
SURGERY FOR OBESITY AND RELATED DISEASES
(2010)
Meeting Abstract
Substance Abuse
M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2012)
Meeting Abstract
Substance Abuse
M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2011)
Meeting Abstract
Gastroenterology & Hepatology
Fengming Wang, Brian Finck, Min You
Meeting Abstract
Gastroenterology & Hepatology
Zheng Shen, Michel Murr, Yanhua Peng, Min You
Meeting Abstract
Substance Abuse
M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2010)
Meeting Abstract
Substance Abuse
L. Le, C. Q. Rogers, X. Liang, Z. Shen, X. Li, M. M. Murr, Y. Peng, M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2010)
Meeting Abstract
Substance Abuse
C. Q. Rogers, X. Liang, Z. Shen, D. Rideout, M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2009)
Meeting Abstract
Substance Abuse
F. Wang, Z. Shen, X. Liang, A. Nelson, C. Q. Rogers, B. N. Finck, M. You
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2010)