Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

And four equals one: Presenilin takes the  -secretase role by itself

(2010) C. B. Lessard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AlphaLISA Immunoassay Platform— The “No-Wash” High-Throughput Alternative to ELISA

(2009) Martina Bielefeld-Sevigny   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Modulation of  -secretase specificity using small molecule allosteric inhibitors

(2009) C. C. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Stereo-controlled synthesis of novel photoreactive γ-secretase inhibitors

(2008) Guangli Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2 γ-Secretase Complexes

(2008) Lisa Placanica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Vulnerability of Hippocampal Neurons from Presenilin-1 Mutant Knock-In Mice to Amyloid β-Peptide Tox

(2003) Qing Guo et al.   JOURNAL OF NEUROCHEMISTRY