NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

(2011) Gregory A Esparza et al.   Innate Immunity

The Ectodomain of the Toll-like Receptor 4 Prevents Constitutive Receptor Activation

(2011) Gabriela Panter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions

(2011) J. Meng et al.   JOURNAL OF IMMUNOLOGY

From agonist to antagonist: Structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins

(2011) Mari L. DeMarco et al.   MOLECULAR IMMUNOLOGY

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand Binding

(2010) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Use of Relaxation Enhancements in a Paramagnetic Environment for the Structure Determination of Proteins Using NMR Spectroscopy

(2009) Tobias Madl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Pathogen recognition by innate immunity and its signaling

(2009) Shizuo AKIRA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Isolation of Monomeric and Dimeric Secreted MD-2

(2008) Athmane Teghanemt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY