Article
Pharmacology & Pharmacy
Qian Yu, Chang Li, Qinghui Niu, Jigang Wang, Zhaodi Che, Ke Lei, He Ren, Boyi Ma, Yixing Ren, Pingping Luo, Zhuming Fan, Huan Zhang, Zhaohui Liu, George L. Tipoe, Jia Xiao
Summary: The increased expression of hepatic cyclooxygenase 1 (COX1) in patients with nonalcoholic steatohepatitis (NASH) and diet-induced NASH models is associated with impaired autophagy. COX1 interacts with WD repeat domain, phosphoinositide interacting 2 (WIPI2) to protect against NASH. Targeting the COX1-WIPI2 axis may be a novel therapeutic strategy for NASH.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Endocrinology & Metabolism
David B. Stagg, Jacob R. Gillingham, Alisa B. Nelson, Justin E. Lengfeld, D. Andre d'Avignon, Patrycja Puchalska, Peter A. Crawford
Summary: Ketone bodies have an impact on liver homeostasis, particularly through the oxidation/reduction metabolism of ketone bodies, with BDH1 playing a significant role in hepatic mitochondrial redox, liver physiology, and overall ketone body homeostasis.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Katherine Byrnes, Niani Tiaye Bailey, Kamal Baral, Arissa Mercer, Spandan Joshi, Nickol Wahby, Tyler Rorison, Gang Liu, Xiao-Ming Yin, Bilon Khambu
Summary: Hepatotoxins activate the hepatic survival pathway, but impaired survival pathways may contribute to liver injury. The role of hepatic autophagy, a cellular survival pathway, was investigated in cholestatic liver injury caused by a hepatotoxin. Impaired autophagy exacerbates hepatotoxin-induced cholestatic liver injury, and promoting autophagy may serve as a new therapeutic approach for hepatotoxin-induced liver damage.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Wilhelm Sjoland, Annika Wahlstrom, Kassem Makki, Marc Scholer, Antonio Molinaro, Lisa Olsson, Thomas Uwe Greiner, Robert Caesar, Jan Freark de Boer, Folkert Kuipers, Fredrik Backhed, Hanns-Ulrich Marschall
Summary: Mice with deletion of Cyp2c70 exhibit features of hepatobiliary disease and can serve as a model for studying bile acid interactions in cholestatic liver disease. Germ-free Cyp2c70-/- mice showed reduced neonatal survival, liver fibrosis, and cholangiocyte proliferation. Colonization with a microbiota, particularly from conventionally raised mice, improved the liver phenotype in Cyp2c70-/- mice and was associated with changes in bile acid composition and gut microbiota.
Article
Multidisciplinary Sciences
Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kong
Summary: Palmitoylation and depalmitoylation homeostasis is crucial for proper physiological functions, particularly in the central nervous system (CNS). GFAP is readily palmitoylated in vitro and in vivo, with palmitoylated GFAP promoting astrocyte proliferation. PPT1 depalmitoylates GFAP, and elevated levels of palmitoylated GFAP in PPT1-knockin mice may accelerate astrocyte proliferation and contribute to astrogliosis in INCL.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Nana Wang, Zhijie Sheng, ShenMin Zhou, Fei Jiang, Zengli Zhang
Summary: This study found that lead exposure exacerbated obesity and metabolic disorders in high-fat diet mice, possibly by inhibiting the insulin signaling pathway and accelerating fatty acid synthesis. In addition, lead also aggravated the disruption of gut microbiota caused by high-fat diet.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alyssa Kriegermeier, Angela Hyon, Meredith Sommars, Susan Hubchak, Brian LeCuyer, Xiaoying Liu, Grant Barish, Richard M. Green
Summary: The study revealed that weanling mice exhibit attenuated hepatic XBP1 signaling and impaired UPR activation, leading to increased susceptibility to bile acid-induced hepatic injury compared to adult mice.
Article
Biochemistry & Molecular Biology
Iliana Lopez-Soldado, Joan J. Guinovart, Jordi Duran
Summary: Increasing liver glycogen content can reduce the diabetic phenotype independently of circulating insulin. This strategy was validated in Akita mice, lowering blood glucose levels and food intake, restoring hepatic energy state, and normalizing gluconeogenesis and glycolysis back to nondiabetic levels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Qingen Da, Mei Hong, Neal L. Weintraub, David J. Fulton, Eric J. Belin de Chantemele, Yuqing Huo
Summary: This study found that endothelial cell AMPKα1/PRKAA1 deficiency unexpectedly alleviated high fat diet-induced metabolic syndrome. The experimental results showed that knockdown of PRKAA1 led to reduced endothelial cell inflammation, decreased body weight and fat mass, while also improving glucose clearance and insulin sensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takashi Maeda
Summary: In a study on non-obese mice under starvation conditions, it was found that Ctrp3 KO mice had increased levels of alanine aminotransferase and aspartate aminotransferase in the liver after a 20-hour fast, along with lower concentrations of certain amino acids. This suggests that CTRP3 may play novel roles in regulating gluconeogenesis and amino acid metabolism in the liver during starvation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Environmental Sciences
Su Liu, Yafeng Liu, Dong Zhang, Huan Li, Xicheng Shao, Pengfei Xie, Jianmei Li
Summary: This study aimed to investigate the effects of PFBS on liver function under different dietary conditions. The results showed that PFBS exposure led to liver injury and lipid metabolism disorders, and restricted diet further intensified these adverse effects. Metabolomics analysis revealed significant alterations in lipid-related metabolites in the liver, while 16S rRNA sequencing analysis showed an imbalance of gut microbial communities caused by PFBS exposure. Additionally, disruptions in the expression of genes involved in lipid production and consumption may significantly contribute to lipid imbalance in the liver.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Ben M. Lawrence, Liza O'Donnell, Lee B. Smith, Diane Rebourcet
Summary: Androgens are crucial for male sexual development, masculinisation, and fertility. HSD17B3 deficiency can lead to disorders of sexual development (DSD). Recent studies suggest differences in testosterone production between mice and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rui Guo, Lin Chen, Jinyan Zhu, Jiaomei Li, Qingchao Ding, Kaixin Chang, Qiang Han, Songtao Li
Summary: The composition of dietary oil plays a crucial role in the development of alcoholic fatty liver disease (AFLD), with saturated fatty acid-rich oil protecting against AFLD and polyunsaturated fatty acid-rich oil aggravating the disease. However, there has been limited research on how monounsaturated fatty acid (MUFA)-enriched oil controls the pathological processes of AFLD. This study aimed to evaluate the impact of MUFA-enriched extra virgin olive oil (OO) on AFLD, and the results showed that dietary OO significantly worsened alcohol-induced liver dysfunction, as confirmed by histological examinations and disturbed biochemical parameters.
Article
Multidisciplinary Sciences
Beatrice S-Y Choi, Noemie Daniel, Vanessa P. Houde, Adia Ouellette, Bruno Marcotte, Thibault V. Varin, Cecile Vors, Perrine Feutry, Olga Ilkayeva, Marcus Stahlman, Philippe St-Pierre, Fredrik Backhed, Angelo Tremblay, Phillip J. White, Andre Marette
Summary: The study reveals that a mixed protein source commonly found in western diets exacerbates diet-induced obesity and insulin resistance by activating hepatic mTORC1/S6K1 signaling via microbial production of branched-chain fatty acids (BCFA). These effects are associated with alterations in gut microbiota and early changes in microbial production of BCFA.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo
Summary: The study revealed that hormones produced by ovaries play crucial roles in regulating hepatic glucose and lipid metabolism as well as communicating with the gut microbiota in females.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Ophthalmology
Neema Ghorbani Mojarrad, Denis Plotnikov, Cathy Williams, Jeremy A. Guggenheim, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Y. L. Chua, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John E. J. Gallacher, David F. Garway-Heath, Jane Gibson, Dan Gore, Jeremy A. Guggenheim, Chris J. Hammond, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pirro Hysi, Pearse A. Keane, Sir Peng T. Khaw, Anthony P. Khawaja, Gerassimos Lascaratos, Andrew J. Lotery, Tom Macgillivray, Sarah Mackie, Keith Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. Mckay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah A. Muthy, Eoin O'Sullivan, Chris G. Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Veronique Vitart, Stephen A. Vernon, Ananth C. Viswanathan, Cathy Williams, Katie Williams, Jayne V. Woodside, Max M. Yates, Jennifer Yip, Yalin Zheng
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Heather Waterman, Simon Read, James Edwards Morgan, David Gillespie, Claire Nollett, Davina Allen, Marjorie Weiss, Pippa Anderson
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Medicine, General & Internal
Simon Read, James Morgan, David Gillespie, Claire Nollett, Marjorie Weiss, Davina Allen, Pippa Anderson, Heather Waterman
PATIENT PREFERENCE AND ADHERENCE
(2020)
Review
Nutrition & Dietetics
Gloria Cimaglia, Marcela Votruba, James E. Morgan, Helder Andre, Pete A. Williams
Article
Ophthalmology
Pakinee Pooprasert, Dana Ahnood, Tina Parmar, Wanxin Wang, Tafadzwa Young-Zvandasara, James Morgan
Summary: This study investigated visual impairment, refractive errors, and barriers to eye care among the homeless population in Cardiff, UK. Findings show a significant disparity in ocular health, visual acuity, and refractive error compared to the general population. 50% of homeless participants had not received optometric care in the last 5 years.
Article
Ophthalmology
James R. Tribble, Eirini Kokkali, Amin Otmani, Flavia Plastino, Emma Lardner, Rupali Vohra, Miriam Kolko, Helder Andre, James E. Morgan, Pete A. Williams
Summary: Animal models of glaucoma show that unilateral or bilateral ocular hypertensive glaucoma can lead to increased neuroinflammatory responses, with more marked effects in animals with bilateral glaucoma. Unilateral glaucoma can also activate microglia in the contralateral eye, indicating the need for caution when using the contralateral eye as a control. Neuroinflammatory protein responses identified in this study may serve as potential disease-modifiable targets.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
James R. Tribble, Amin Otmani, Eirini Kokkali, Emma Lardner, James E. Morgan, Pete A. Williams
Summary: An inducible, magnetic bead model in Brown Norway rats was developed to replicate glaucoma features in human eyes. The model successfully demonstrated degeneration across multiple retinal ganglion cell compartments, providing a platform for testing glaucoma therapeutics.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Neurosciences
Ryan J. Bevan, Tim R. Hughes, Pete A. Williams, Mark A. Good, B. Paul Morgan, James E. Morgan
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet Segre, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Summary: The authors conducted a meta-analysis of genome-wide association studies in 34,179 cases of POAG, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities. Integration of multiple lines of genetic evidence supports the functional relevance of the identified POAG risk loci.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
R. L. Bartlett, B. E. Frost, K. E. Mortlock, J. R. Fergusson, N. White, J. E. Morgan, R. North, J. Albon
Summary: Regional axonal-related parameters in POAG patients were evaluated to study differences in optic nerve head structure at different disease stages, which were associated with visual field damage severity. Novel axon-derived indices may serve as potential biomarkers for early detection of glaucoma and identification of ONHs at risk.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Ryan J. Bevan, Pete A. Williams, Caroline T. Waters, Rebecca Thirgood, Amanda Mui, Sharon Seto, Mark Good, James E. Morgan, Marcela Votruba, Irina Erchova
BRAIN COMMUNICATIONS
(2020)
Meeting Abstract
Ophthalmology
Mukhit Kulmaganbetov, Nantheera Anantrasirichai, Alin Achim, Julie Albon, Nick White, James Edwards Morgan
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Article
Biology
Pieter W. M. Bonnemaijer, Elisabeth M. van Leeuwen, Adriana I. Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P. Khawaja, Mark Simcoe, Rene Hoehn, Angela J. Cree, Rob P. Igo, Kathryn P. Burdon, Jamie E. Craig, Alex W. Hewitt, Jost Jonas, Chiea-Cheun Khor, Francesca Pasutto, David A. Mackey, Paul Mitchell, Aniket Mishra, Calvin Pang, Louis R. Pasquale, Henriette Springelkamp, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Ananth C. Viswanathan, Robert Wojciechowski, Tien Wong, Terrri L. Young, Tanja Zeller, Denize Atan, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Y. L. Chua, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John E. J. Gallacher, David F. Garway, Jane Gibson, Dan Gore, Jeremy A. Guggenheim, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pearse A. Keane, Peng T. Khaw, Gerassimos Lascaratos, Tom Macgillivray, Sarah Mackie, Keith Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. Mckay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah A. Muthy, Eoin O'Sullivan, Chris G. Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Stephen A. Vernon, Ananth C. Viswanathan, Cathy Williams, Katie Williams, Jayne V. Woodside, Max M. Yates, Jennifer Yip, Yalin Zheng, Rand Allingham, Don Budenz, Jessica Cooke Bailey, John Fingert, Douglas Gaasterland, Teresa Gaasterland, Jonathan L. Haines, Lisa Hark, Michael Hauser, Jae Hee Kang, Peter Kraft, Richard Lee, Paul Lichter, Yutao Liu, Syoko Moroi, Louis R. Pasquale, Margaret Pericak, Anthony Realini, Doug Rhee, Julia R. Richards, Robert Ritch, William K. Scott, Kuldev Singh, Arthur Sit, Douglas Vollrath, Robert Weinreb, Gadi Wollstein, Don Zack Wilmer, Aslihan Gerhold-Ay, Stefan Nickels, James F. Wilson, Caroline Hayward, Thibaud S. Boutin, Ozren Polasek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew J. Lotery, Janey L. Wiggs, Ching-Yu Cheng, Pirro G. Hysi, Christopher J. Hammond, Alberta A. H. J. Thiadens, Stuart MacGregor, Caroline C. W. Klaver, Cornelia M. van Duijn
COMMUNICATIONS BIOLOGY
(2019)
Article
Ophthalmology
Sharon Y. L. Chua, Anthony P. Khawaja, James Morgan, Nicholas Strouthidis, Charles Reisman, Andrew D. Dick, Peng T. Khaw, Praveen J. Patel, Paul J. Foster, Denize Atan, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, David P. Crabb, Alexander Day, Parul Desai, Bal Dhillon, Cathy Egan, Sarah Ennis, Marcus Fruttiger, John E. J. Gallacher, David F. Garway-Heath, Jane Gibson, Dan Gore, Jeremy A. Guggenheim, Chris J. Hammond, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pirro Hysi, Pearse A. Keane, Gerassimos Lascaratos, Andrew J. Lotery, Tom Macgillivray, Sarah Mackie, Michelle McGaughey, Bernadette McGuinness, Gareth J. McKay, Martin McKibbin, Tony Moore, Zaynah A. Muthy, Eoin O'Sullivan, Chris G. Owen, Euan Paterson, Tunde Peto, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Veronique Vitart, Stephen A. Vernon, Ananth C. Viswanathan, Cathy Williams, Katie Williams, Jayne Woodside, Max M. Yates, Yalin Zheng
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
Sharon Y. L. Chua, Anthony P. Khawaja, Andrew D. Dick, James Morgan, Baljean Dhillon, Andrew J. Lotery, Nicholas G. Strouthidis, Charles Reisman, Tunde Peto, Peng T. Khaw, Paul J. Foster, Praveen J. Patel
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)