Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A

A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility

(2012) H. Grise et al.   JOURNAL OF VIROLOGY

Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

(2011) Dries Verdegem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New targets for antiviral therapy of chronic hepatitis C

(2011) Sandra Bühler et al.   LIVER INTERNATIONAL

Therapeutics: New drugs hit the target

(2011) Jana Schlütter   NATURE

Introduction: A smouldering public-health crisis

(2011) Lauren Gravitz   NATURE

The dawn of a new era in HCV therapy

(2011) Sandra Ciesek et al.   Nature Reviews Gastroenterology & Hepatology

A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

(2011) C. T. Ranjith-Kumar et al.   PLoS One

Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors

(2010) X. Puyang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ligand-induced changes in hepatitis C virus NS5B polymerase structure

(2010) Karen Rigat et al.   ANTIVIRAL RESEARCH

Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes

(2010) U. Chatterji et al.   JOURNAL OF GENERAL VIROLOGY

Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B

(2010) Steven R. LaPlante et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of De Novo-Initiated RNA Synthesis in Hepatitis C Virus RNA-Dependent RNA Polymerase by Intermolecular Interactions

(2010) S. Chinnaswamy et al.   JOURNAL OF VIROLOGY

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A

(2010) Fiona Fernandes et al.   PLoS One

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

(2010) Lotte Coelmont et al.   PLoS One

The Domain 2 of the HCV NS5A Protein Is Intrinsically Unstructured

(2010) Xavier Hanoulle et al.   PROTEIN AND PEPTIDE LETTERS

Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care

(2010) Leen Delang et al.   Viruses-Basel

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

(2009) S. Hopkins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded

(2009) Xavier Hanoulle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase

(2009) Julie A. Heck et al.   BIOCHEMICAL PHARMACOLOGY

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B

(2009) Xavier Hanoulle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

(2009) Udayan Chatterji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

(2009) P. Simister et al.   JOURNAL OF VIROLOGY

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

(2009) Z. Liu et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

(2009) Artur Kaul et al.   PLoS Pathogens

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

(2008) F. Yang et al.   JOURNAL OF VIROLOGY

Hepatitis C virus infection protein network

(2008) B de Chassey et al.   Molecular Systems Biology

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens