Article
Multidisciplinary Sciences
Martyna Kosno, Simon L. Currie, Ashwani Kumar, Chao Xing, Michael K. Rosen
Summary: In this study, the formation of biomolecular condensates by the oncogenic fusion protein BRD4-NUT and its associated histone acetyltransferase p300 were investigated. The researchers found that a minimal fragment of NUT fused with BRD4 is sufficient to bind p300 and form condensates. The results suggest a model for condensate formation involving positive feedback and phase separation, and identify different regions of p300 that contribute to condensate formation and transcriptional regulation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Martin Volek, Sofia Kolesnikova, Katerina Svehlova, Pavel Srb, Rachel Sgallova, Tereza Streckerova, Juan A. Redondo, Vaclav Veverka, Edward A. Curtis
Summary: G-quadruplexes are noncanonical nucleic acid structures with diverse biological functions, each function having different sequence requirements. Mutations can significantly alter biochemical specificity, with mutations in tetrads having larger effects. Changes in specificity are correlated with changes in multimeric state. The sequence requirements of G-quadruplexes with different functions are overlapping but distinct.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Plant Sciences
Rongbin Hu, Nayma P. Dias, Nourolah Soltani, Jose Vargas-Asencio, Darrell D. Hensley, Keith L. Perry, Leslie L. Domier, M. R. Hajimorad
Summary: The study conducted a survey of viruses and viroids in both cultivated and wild grapevines, detecting multiple viruses and viroids in both populations. Differences in viral sequences between cultivated and wild grapevines suggest limited virus movement between the two populations.
Article
Behavioral Sciences
Lenia Amaral, Fredrik Bergstrom, Jorge Almeida
Summary: Research has found that long-range computations are essential for local processing of information in object recognition. Functional connectivity between specific brain regions and category preferences are independent, indicating that regions processing tools and hands maintain object topography in a category-specific way.
Article
Biology
Shreya H. Dhume, Steven A. Connor, Fergil Mills, Parisa Karimi Tari, Sarah H. M. Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T. Roppongi, Hiroshi Kawabe, Shernaz X. Bamji, Yu Tian Wang, Nils Brose, Michael F. Jackson, Ann Marie Craig, Tabrez J. Siddiqui, Katalin Toth
Summary: LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses in hippocampal circuits, and play a role in long-term potentiation and enduring fear memory, contributing to fine-tuning of hippocampal circuit connectivity and plasticity.
Article
Multidisciplinary Sciences
Valentina Palmerini, Silvia Monzani, Quentin Laurichesse, Rihab Loudhaief, Sara Mari, Valentina Cecatiello, Vincent Olieric, Sebastiano Pasqualato, Julien Colombani, Ditte S. Andersen, Marina Mapelli
Summary: The Drosophila tumour necrosis factor (TNF) system consists of a single ligand, Eiger (Egr), and two receptors. The crystallographic structure of Egr in complex with the extracellular domain of the receptor Grindelwald suggests that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Maria De Luca, David Ronald Bryan, Gary Richard Hunter
Summary: Aging is accompanied by low-grade proinflammatory status. This study found significant associations of SDC4 with MMP-9, cardiovascular hemodynamic phenotypes, heart rate, and blood pressure, but not with proinflammatory cytokines or arterial elasticity.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mimmu K. Hiltunen, Alex J. Timmis, Maren Thomsen, Danai S. Gkotsi, Hideo Iwai, Orquidea M. Ribeiro, Adrian Goldman, Natalia A. Riobo-Del Galdo
Summary: Deleterious mutations in the X-linked PTCHD1 gene may contribute to 1% of autism cases. The function of the PTCHD1 protein is not well understood, but it may be involved in sterol transport and Hedgehog signaling. Experimental evidence suggests that PTCHD1 has distinct cellular functions and binds cholesterol similarly to PTCH1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ayako Maeda, Sachi Takenaka, Tenghua Wang, Brody Frink, Toshiharu Shikanai, Mizuki Takenaka
Summary: C-to-U RNA editing sites in plant organelles exhibit a strong preference for neighboring nucleotides. The PPR domain of RNA editing factors binds to the 5' sequence of target cytidines, while the DYW domain catalyzes the C-to-U deamination. The DYW domain has a distinct preference for neighboring nucleotides, contributing to target selection.
Article
Biochemistry & Molecular Biology
Dristi Bhandari, Ahmed Elshaarrawi, Karen S. Katula
Summary: WNT5A isoforms WNT5A-L(A) and WNT5A-S(B) exhibit distinct and overlapping functions in normal osteoblasts, affecting the expression of differentiation markers and proliferation differently. WNT5A-S(B) enhances beta-catenin signaling, while WNT5A-L(A) increases the proliferation of undifferentiated cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Manhong Xu, Xin Chen, Zihao Yu, Xiaorong Li
Summary: Retinal neovascular, neurodegenerative, and inflammatory diseases, such as diabetic retinopathy, continue to be major causes of blindness worldwide. Pigment epithelium-derived factor (PEDF) is an endogenous factor with various beneficial effects, including neurotrophic activity, anti-angiogenesis, anti-tumorigenesis, and anti-inflammatory activity. Multiple high affinity receptors for PEDF, including adipose triglyceride lipase, laminin receptor, lipoprotein receptor-related protein, plexin domain-containing 1, plexin domain-containing 2, F1-ATP synthase, and vascular endothelial growth factor receptor 2, have been identified and studied. Understanding the interactions between PEDF and its receptors is crucial for elucidating the role of inflammation, angiogenesis, and neurodegeneration in disease progression. This review comprehensively introduces PEDF receptors, focusing on their expression pattern, ligands, related diseases, and signal transduction pathways, with the aim to expand our knowledge of PEDF receptors in the diagnosis and treatment of retinal diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Allah Dad Khan, Muhammad Sayyar Khan, Sajid Ali Khan Bangash, Kashif Naeem, Abdullah Jalal, Muhammad Tayyab
Summary: Among toxic heavy metal(loid)s, cadmium and arsenic have devastating effects on crop productivity and human health. Detoxification mechanisms for Cd and As in plants proceed via a common pathway involving glutathione, although their modes of toxicity differ. Exposure of Brassica juncea seedlings to Cd and As stress resulted in mostly distinct, but partly overlapping responses, affecting growth and biochemical responses. This study provides valuable insights for sustainable plant growth strategies on As and Cd polluted soils.
CROP & PASTURE SCIENCE
(2022)
Article
Psychology
Isabelle Boutet, Elizabeth A. Nelson, Nicholas Watier, Denis Cousineau, Sebastien Beland, Charles A. Collin
Summary: This study delves into holistic face processing using various experimental measures, revealing that it is a multifaceted construct and different measures tap into distinct but partially overlapping elements of it.
ATTENTION PERCEPTION & PSYCHOPHYSICS
(2021)
Article
Oncology
Khandakar A. S. M. Saadat, Widya Lestari, Endrawan Pratama, Teng Ma, Sachiko Iseki, Megumi Tatsumi, Masa-Aki Ikeda
Summary: The study revealed that ARID3A and ARID3B play distinct and overlapping roles in regulating E2F target gene expression, directly binding to E2F target genes and involved in cell cycle progression and suppression of tumor cell growth.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gianlucca G. Nicastro, A. Maxwell Burroughs, Lakshminarayan M. Iyer, L. Aravind
Summary: Recent findings have revealed immune effectors that target nucleotides and the cellular energy currency-free nucleotides. Comparative genomics and sequence-structure analysis have identified several distinct effector domains, which are widely present in prokaryotic immune systems. This study establishes nucleotide-degrading effectors as an emerging immune paradigm and traces their origins back to homologous domains in housekeeping systems.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Patricia Rousselle, Fabienne Braye, Guila Dayan
ADVANCED DRUG DELIVERY REVIEWS
(2019)
Article
Microbiology
Alison A. Jack, Saira Khan, Lydia C. Powell, Manon F. Pritchard, Konrad Beck, Hina Sadh, Lucy Sutton, Alessandra Cavaliere, Hannah Florance, Philip D. Rye, David W. Thomas, Katja E. Hill
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Patricia Rousselle, Marine Montmasson, Cecile Garnier
Article
Multidisciplinary Sciences
Sahar I. Da'as, Angelos Thanassoulas, Brian L. Calver, Konrad Beck, Rola Salem, Alaaeldin Saleh, Iris Kontogianni, Ali Al-Maraghi, Gheyath K. Nasrallah, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F. Anthony Lai, Michail Nomikos
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Immunology
Radka Sebova, Vladena Bauerova-Hlinkova, Konrad Beck, Ivana Nemcovicova, Jacob Bauer, Marcela Kudelova
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Review
Chemistry, Multidisciplinary
Melissa Dussoyer, Anna Michopoulou, Patricia Rousselle
APPLIED SCIENCES-BASEL
(2020)
Article
Biochemistry & Molecular Biology
Anna Michopoulou, Marine Montmasson, Cecile Garnier, Elise Lambert, Guila Dayan, Patricia Rousselle
Article
Biochemistry & Molecular Biology
Amandine Bovay, Vincent Zoete, Pierre J. Rizkallah, Konrad Beck, Philippe Delbreil, Daniel E. Speiser, David K. Cole, Silvia A. Fuertes Marraco
MOLECULAR IMMUNOLOGY
(2020)
Article
Cell & Tissue Engineering
Adeline Desanlis, Marion Albouy, Patricia Rousselle, Amelie Thepot, Morgan Dos Santos, Celine Auxenfans, Christophe Marquette
Summary: The study aims to regenerate dermis through the in situ 3D bioprinting of freshly isolated autologous skin cells. The experiment demonstrates the successful reconstitution of dermis in vitro using medical grade bioink and mechanically extracted skin cells, showing cell proliferation and new production of type I collagen. In vivo experiments in a severe burn murine model indicate that topical application of the medical grade bioink is feasible and well-tolerated, providing groundwork for future 3D bioprinting tissue engineering strategies for patients with severe burns.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eva Roig-Rosello, Patricia Rousselle
Review
Cell Biology
Patricia Rousselle, Chloe Laigle, Gaelle Rousselet
Summary: The epidermis is a specialized epithelium that forms the outermost layer of the skin, providing protection against environmental factors. Basal keratinocytes adhere to the basement membrane and their regulation is crucial for maintaining skin functionality. The components of the basement membrane play key roles in preserving stem cells, establishing cell polarity and promoting skin regeneration during wound healing.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Microbiology
Tristan Rubio, Stephanie Gagne, Charline Debruyne, Chloe Dias, Caroline Cluzel, Doriane Mongellaz, Patricia Rousselle, Stephan Goettig, Harald Seifert, Paul G. Higgins, Suzana P. Salcedo
Summary: The spread of antibiotic-resistant Acinetobacter baumannii poses a significant threat to public health worldwide. This study shows that some clinical isolates of A. baumannii can extensively multiply within cells, creating an intracellular niche that protects the bacteria from immune responses and antibiotic treatments. This finding may contribute to the persistence, relapsing infections, and enhanced mortality associated with A. baumannii.
Meeting Abstract
Biochemistry & Molecular Biology
V. Bauerova, L. Macakova, K. Beck, M. Benko, D. Cierna, E. Kutejova, J. Bauer
Meeting Abstract
Biophysics
Michail Nomikos, Angelos Thanassoulas, Brian L. Calver, Konrad Beck, Vyronia Vassilakopoulou, Luke Buntwal, Iris Konotgianni, Adrian Smith, Bared Safieh-Garabedian, Evangelia Livaniou, Egon Steen Tofti, George Nounesis, F. Anthony Lai
BIOPHYSICAL JOURNAL
(2018)
Article
Immunology
Amandine Bovay, Vincent Zoete, Garry Dolton, Anna M. Bulek, David K. Cole, Pierre J. Rizkallah, Anna Fuller, Konrad Beck, Olivier Michielin, Daniel E. Speiser, Andrew K. Sewell, Silvia A. Fuertes Marraco
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)